Chikungunya and Myositis:  A Case Report in Brazil

Martins, Hugo André de Lima; Bernardino, Silvya Nery; Santos, Camila Cordeiro dos; Ribas, Valdenilson Ribeiro

doi:10.7860/jcdr/2016/23680.9053

Cited by 13 publications

(17 citation statements)

References 6 publications

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“…First, myalgia is a frequent symptom of infection, reported in 44% of 297 cases during the 2013-2014 outbreak in French Polynesia [21], 60% in Martinique's 2015-2016 outbreak [22], as well as in four of eight infected patients returning from Suriname to French Guiana [23]. In addition, muscle involvement has been extensively described in other arbovirus infections: alphaviruses, such as Mayaro, chikungunya and Sindbis viruses, have been reported to cause myalgia and myositis in humans [24] [7], [25], [26], and flaviviruses, e.g. West Nile and dengue viruses, have been associated with myositis [6], [8] and rhabdomyolysis [27], [28].…”

Section: Introductionmentioning

confidence: 99%

Differentiation-dependent susceptibility of human muscle cells to Zika virus infection

Legros¹,

Jeannin²,

Burlaud‐Gaillard³

et al. 2020

PLoS Negl Trop Dis

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Muscle cells are potential targets of many arboviruses, such as Ross River, Dengue, Sindbis, and chikungunya viruses, that may be involved in the physiopathological course of the infection. During the recent outbreak of Zika virus (ZIKV), myalgia was one of the most frequently reported symptoms. We investigated the susceptibility of human muscle cells to ZIKV infection. Using an in vitro model of human primary myoblasts that can be differentiated into myotubes, we found that myoblasts can be productively infected by ZIKV. In contrast, myotubes were shown to be resistant to ZIKV infection, suggesting a differentiationdependent susceptibility. Infection was accompanied by a caspase-independent cytopathic effect, associated with paraptosis-like cytoplasmic vacuolization. Proteomic profiling was performed 24h and 48h post-infection in cells infected with two different isolates. Proteome changes indicate that ZIKV infection induces an upregulation of proteins involved in the activation of the Interferon type I pathway, and a downregulation of protein synthesis. This work constitutes the first observation of primary human muscle cells susceptibility to ZIKV infection, and differentiation-dependent restriction of infection from myoblasts to myotubes. Since myoblasts constitute the reservoir of stem cells involved in reparation/regeneration in muscle tissue, the infection of muscle cells and the viral-induced alterations observed here could have consequences in ZIKV infection pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Differentiation-dependent susceptibility of human muscle cells to Zika virus infection

Legros¹,

Jeannin²,

Burlaud‐Gaillard³

et al. 2020

PLoS Negl Trop Dis

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“…Myositis at presentation appears rare but has been reported following encephalitis. 3 Presentation as quadriparesis without neuropathy has not been reported yet to our knowledge.…”

Section: Discussionmentioning

confidence: 87%

Chikungunya-induced inflammatory myositis: a case report in India

et al. 2019

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Chikungunya fever is a benign and self-limiting disease caused by an RNA virus belonging to genus alphavirus and transmitted by infected Aedes mosquitoes. However, a number of atypical presentations involving various systems have been reported. Among the neurological complications, encephalitis, myelitis, Guillain-Barre syndrome and optic neuritis are commonly seen. However, its presentation as isolated inflammatory myositis causing quadriplegia is extremely rare. We report a 35-year-old woman with quadriplegia caused by chikungunya-induced inflammatory myositis. The diagnosis was confirmed with clinical examination, electromyography study, muscle biopsy findings and exclusion of other causes. There have been case reports of inflammatory myositis in association with various infections as well as in association with other neurological presentations in chikungunya. However, this may be the first case report of isolated inflammatory myositis associated with chikungunya fever.

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“…The disease was first considered self-limited, but there has been growing evidence of severe manifestations such as uveitis, myocarditis, meningoencephalitis, Guillain-Barré syndrome, and cranial nerve palsy [3]. In Brazil, however, there has been evidence that neurological symptoms resulting from infection by the Chikungunya virus are not rare, as previously believed [4]. Report on psychiatric manifestations due to Chikungunya virus infection include: insomnia, aggressiveness, pessimism, loss of concentration, depression, and mental confusion [5].…”

Section: Editorialmentioning

confidence: 98%

Psychiatric Symptoms in Patients with Chikungunya Fever

Aguiar¹

2017

J Drug Metab Toxicol

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Chikungunya and Myositis: A Case Report in Brazil

Cited by 13 publications

References 6 publications

Differentiation-dependent susceptibility of human muscle cells to Zika virus infection

Differentiation-dependent susceptibility of human muscle cells to Zika virus infection

Chikungunya-induced inflammatory myositis: a case report in India

Psychiatric Symptoms in Patients with Chikungunya Fever

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