Chikungunya-induced inflammatory myositis: a case report in India

Abstract

Chikungunya fever is a benign and self-limiting disease caused by an RNA virus belonging to genus alphavirus and transmitted by infected Aedes mosquitoes. However, a number of atypical presentations involving various systems have been reported. Among the neurological complications, encephalitis, myelitis, Guillain-Barre syndrome and optic neuritis are commonly seen. However, its presentation as isolated inflammatory myositis causing quadriplegia is extremely rare. We report a 35-year-old woman with quadriplegia caused by chikungunya-induced inflammatory myositis. The diagnosis was confirmed with clinical examination, electromyography study, muscle biopsy findings and exclusion of other causes. There have been case reports of inflammatory myositis in association with various infections as well as in association with other neurological presentations in chikungunya. However, this may be the first case report of isolated inflammatory myositis associated with chikungunya fever.

Antisynthetase Syndrome after chikungunya infection: A case report

“…5,8 Dev et al (2019) reported a case of inflammatory myositis following chikungunya infection in 2019 in India. 8 Martins et al (2016) reported a case of a patient presenting with myositis and encephalitis post-CHIKV infection in Brazil. 5 However, this is the first case of antisynthetase syndrome post-chikungunya infection characterized in literature.…”

“…Dev et al (2019) reported a case of inflammatory myositis following chikungunya infection in 2019 in India 8 . Martins et al (2016) reported a case of a patient presenting with myositis and encephalitis post‐CHIKV infection in Brazil 5 .…”

“…studied viral relationship so far has been with retrovirus 7 . However, there are fewer case reports in the literature highlighting association of CHIKV with the development of autoimmune diseases, especially inflammatory myopathies 5,8 …”

Arboviruses and Muscle Disorders: From Disease to Cell Biology

“…Other studies have also reported muscle alteration in human specimens [55][56][57][58]60,61], although the presence of the virus is not always demonstrated. Table 1 illustrates cases of muscle ex vivo studies from infected human patients.…”

“…Other studies have also reported muscle alteration in human specimens [ 55 , 56 , 57 , 58 , 60 , 61 ], although the presence of the virus is not always demonstrated.…”