Chikungunya Infection in Travelers

Hochedez, Patrick; Jauréguiberry, Stéphane; Debruyne, Monique; Bossi, Philippe; Hausfater, Pierre; Brücker, Gilles; Bricaire, François; Caumes, Éric

doi:10.3201/eid1210.060495

Cited by 131 publications

(84 citation statements)

References 12 publications

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“…Upon returning to their native countries these travellers were still positive for the virus [52,53,54]. In Italy, the national infectious diseases surveillance system reported 22 returning travellers with symptoms of CHIKV infection from the Indian Ocean islands (Mauritius, Reunion, Madagascar) between January 2006 and March 2007 who were CHIKV serum positive [54].…”

Section: The Appearance Of Chikungunya Virus In Italy: An Example Of mentioning

confidence: 99%

Chikungunya: an emerging and spreading arthropod-borne viral disease.

Cavrini

Gaibani

Pierro

et al. 2009

J Infect Dev Ctries

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The virus causing Chikungunya disease was identified over 50 years ago; however, because the disease appeared only in developing countries, little research on it has been done. Research interest in the disease increased after an important epidemiological outbreak occurred in 2005 on the French metropolitan island of La Reunion located in the south-eastern part of the Indian Ocean. In 2007, a smaller outbreak of Chikungunya developed in the north-eastern part of Italy made possible by immigration of a viremic patient from the Indian Ocean area and the enormous population of Aedes albopictus in Italy. Currently, Chikungunya is spreading in Southeast Asian aspects, clinical pictures, diagnosis and treatment of the disease caused by Chikungunya virus.

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Section: The Appearance Of Chikungunya Virus In Italy: An Example Of mentioning

confidence: 99%

Chikungunya: an emerging and spreading arthropod-borne viral disease.

Cavrini

Gaibani

Pierro

et al. 2009

J Infect Dev Ctries

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“…Moreover, the first indigenous CHIKV outbreak in Europe was reported from Italy in 2007 (Rezza et al, 2007). Several other European countries (Hochedez et al, 2006;Parola et al, 2006;Veber et al, 2007) and the USA (Lanciotti et al, 2007) have also reported imported infections, raising serious concerns about the potential burden of CHIKV infections.…”

Section: Introductionmentioning

confidence: 99%

Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore

Hapuarachchi

Bandara

Sumanadasa

et al. 2009

Journal of General Virology

129

135

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Chikungunya fever swept across many South and South-east Asian countries, following extensive outbreaks in the Indian Ocean Islands in 2005. However, molecular epidemiological data to explain the recent spread and evolution of Chikungunya virus (CHIKV) in the Asian region are still limited. This study describes the genetic Characteristics and evolutionary relationships of CHIKV strains that emerged in Sri Lanka and Singapore during 2006-2008. The viruses isolated in Singapore also included those imported from the Maldives (n51), India (n52) and Malaysia (n531). All analysed strains belonged to the East, Central and South African (ECSA) lineage and were evolutionarily more related to Indian than to Indian Ocean Islands strains. Unique genetic characteristics revealed five genetically distinct subpopulations of CHIKV in Sri Lanka and Singapore, which were likely to have emerged through multiple, independent introductions. The evolutionary network based on E1 gene sequences indicated the acquisition of an alanine to valine 226 substitution (E1-A226V) by virus strains of the Indian sublineage as a key evolutionary event that contributed to the transmission and spatial distribution of CHIKV in the region. The E1-A226V substitution was found in 95.7 % (133/139) of analysed isolates in 2008, highlighting the widespread establishment of mutated CHIKV strains in Sri Lanka, Singapore and Malaysia. As the E1-A226V substitution is known to enhance the transmissibility of CHIKV by Aedes albopictus mosquitoes, this observation has important implications for the design of vector control strategies to fight the virus in regions at risk of chikungunya fever.

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“…[14][15][16] For example, chikungunya fever, caused by the alphavirus chikungunya virus, is an emerging infectious disease in endemic and non-endemic regions and can be misdiagnosed as dengue fever, which is largely sympatric in the Old World. [16][17][18][19][20][21] Because the clinical presentation of arboviral disease is often non-specific, reliance on diagnostic testing becomes necessary for accurate differentiation. 22,23 Current laboratory methods are limited by lack of specificity and make conclusive diagnosis difficult.…”

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confidence: 99%

Serologic Evidence of Arboviral Infections among Humans in Kenya

Sutherland

Cash

Huang

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. Outbreaks of arthropod-borne viral infections occur periodically across Kenya. However, limited surveillance takes place during interepidemic periods. Using serum samples obtained from asymptomatic persons across Kenya in 2000-2004, we assessed (by indirect immunofluorescent assay) prevalence of IgG against yellow fever virus (YFV), West Nile virus (WNV), tick-borne encephalitis virus (TBEV), dengue virus serotypes 1-4 (DENV1-4), and chikungunya virus (CHIKV). Older persons on the Indian Ocean coast were more likely to be seropositive than children inland: YFV = 42% versus 6%, WNV = 29% versus 6%, TBEV = 16% versus 6%, DENV-1 = 63% versus 9%, DENV-2 = 67% versus 7%, DENV-3 = 55% versus 6%, DENV-4 = 44% versus 8%, and CHIKV = 37% versus 20%. Among inland samples, children in lowlands were more likely to be seropositive for CHIKV (42% versus 0%) than children in highlands. In Kenya, transmission of arboviral infection continues between known epidemics and remains common across the country.

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Chikungunya Infection in Travelers

Abstract: The largest described outbreak of chikungunya virus has been occurring on the islands of the southwest Indian Ocean since March 2005. We describe the manifestations of chikungunya virus infection in travelers returning from these islands, with focus on skin manifestations.

Cited by 131 publications

References 12 publications

Chikungunya: an emerging and spreading arthropod-borne viral disease.

Chikungunya: an emerging and spreading arthropod-borne viral disease.

Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore

Serologic Evidence of Arboviral Infections among Humans in Kenya

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