Chikungunya virus: clinical aspects and treatment - A Review

Cunha, Rivaldo Venâncio da; Trinta, Karen Soares

doi:10.1590/0074-02760170044

Cited by 169 publications

(165 citation statements)

References 44 publications

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“…During the more recent CHIKV outbreaks, total or partial alopecia on the head or body, predominately in female patients, and ophthalmological alterations, such as uveitis and retinitis, were described during the chronic phase of infection (Martínez-Pulgarín et al, 2016;Cunha and Trinta, 2017).…”

Section: Atypicalmentioning

confidence: 99%

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

et al. 2018

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Chikungunya fever is a mosquito-borne viral illness characterized by a sudden onset of fever associated with joint pains. It was first described in the 1950s during a Chikungunya virus (CHIKV) outbreak in southern Tanzania and has since (re-) emerged and spread to several other geographical areas, reaching large populations and causing massive epidemics. In recent years, CHIKV has gained considerable attention due to its quick spread to the Caribbean and then in the Americas, with many cases reported between 2014 and 2017. CHIKV has further garnered attention due to the clinical diagnostic difficulties when Zika (ZIKV) and dengue (DENV) viruses are simultaneously present. In this review, topical CHIKV-related issues, such as epidemiology and transmission, are examined. The different manifestations of infection (acute, chronic and atypical) are described and a particular focus is placed upon the diagnostic handling in the case of ZIKV and DENV co-circulating. Natural and synthetic compounds under evaluation for treatment of chikungunya disease, including drugs already licensed for other purposes, are also discussed. Finally, previous and current vaccine strategies, as well as the control of the CHIKV transmission through an integrated vector management, are reviewed in some detail.

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Section: Atypicalmentioning

confidence: 99%

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

et al. 2018

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“…Os achados sobre sinais e sintomais mais frequentes no nosso estudo corroboram com outras pesquisas [9,11,15,16], nas quais os sintomas mais encontrados foram febre e artralgia, mialgia e cefaleia. Embora o conjunto de febre e artralgia tenha excelente valor preditivo positivo durante um surto de chikungunya, a maioria dos pacientes suspeitos vive em área endêmica de dengue, onde existe a chance de coinfecção e de infecções subsequentes e onde erros no diagnóstico clínico podem acontecer [6].…”

Section: Conclusãounclassified

Aspectos epidemiológicos da Chikungunya no Estado do Espírito Santo, Brasil, 2014 a 2017

Silva¹,

Santos²,

Moussallem³

et al. 2018

GUARA

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ResumoPara descrever a distribuição temporal e espacial da Chikungunya, no estado do Espírito Santo, foi realizado um estudo descritivo e ecológico, entre 2014 e 2017. Foram analisadas as notificações do SINAN -Sistema de Informação de Agravos de Notificação, organizadas pelo programa Excel e analisadas pelo programa SPSS e o software ArcGIS para construir os mapas. Registrou-se um aumento progressivo dos casos desde 2015, com a incidência em 2017 (12,8/100mil habitantes) dobrando em relação a 2016 (6,3/100mil habitantes). Dos pacientes confirmados, 392 (66,9%) foram mulheres e 194 (33,1%) homens. A cor parda foi a mais frequente e 15% da população tinha escolaridade de ensino médio completo. A faixa etária de 41 a 60 anos foi a mais acometida. Os sinais e sintomas mais comuns foram: febre (85,5%), artralgia (79,7%), mialgia (78,3%), cefaléia (67,4%). Cerca de 16,4% da população descrevia alguma comorbidade. Foram confirmados 288 (49,1%) por exames laboratoriais. O caráter epidêmico da Chikungunya com elevada taxa de morbidade associada à artralgia persistente, tendo como consequência a redução da produtividade e da qualidade de vida, apontam a necessidade dos serviços de saúde se organizarem para o melhor enfrentamento da doença e disponibilizar um atendimento adequado, multiprofissional e ofertado na atenção primária de saúde. AbstractIn order to describe the temporal and spatial distribution of Chikungunya in Espírito Santo, it was made an observational study between 2014 and 2017. We analyzed the notifications in SINAN and organized it at the Excel program. Then, the data were analyzed by SPSS and Arc-GIS software to construct the maps. A progressive rise in the numbers of cases was registered since 2015, and the incidence in 2017 (12,8/100.000 habitants) doubled in relation to 2016 (6,3/100.000 habitants). From the confirmed patients, 392 (66,9%) were women and 194 (33,1%) were men. The brown-skinned people and those between 41-60 year-old were the most affected and 15% of the population had high-school level of education. The most common signs and symptoms were: fever (85,5%), arthralgias (79,7%), myalgias (78,3%), headache (67,4%). Approximately 16,4% of the population informed any comorbidity. 288 cases (49,1%) were confirmed by laboratory. The epidemic profile of Chikungunya, with high morbidity rates, associated to persistent arthralgias, resulting in productivity reduction and quality of life, suggest the urgent need of better organization of the health services to face the disease and provide an appropriate and multiprofessional service in public health departments.

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“…mosquitoes and has infected millions of people annually causing CHIKV fever (CHKF) in the tropical and subtropical regions of the world [29]. CHIKF is characterized by a self-limiting acute stage, with symptoms of fever, headache, rash and arthralgia which lasts for 1-2 weeks [8]. In 30-40% of cases, there is a chronic stage where patients develop an incapacitating arthritis which may persist for months to years, and thereby imposes a burden on the population in terms of disability adjusted life years (DALY) [8, 11].…”

Section: Introductionmentioning

confidence: 99%

Chikungunya virus infection impairs the function of osteogenic cells

Roy

Shi

Duan

et al. 2020

Preprint

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19Chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus, spread by 20 the Aedes species (sp.) mosquitoes. Chikungunya virus (CHIKV) causes a condition 21 characterized by high fever, headache, rash, and joint pain. Recent investigations 22Presently, no vaccines or treatment options are available for CHIKV infection. Joint pain 42 is one of the major concerns. Although studies have shown an association between 43 bone pathology and infection, the molecular pathogenesis in context of bone pathology 44 is poorly defined. Here, we demonstrate for the first time that BMSCs and BMSC-45 derived osteogenic cells are susceptible to CHIKV infection and infection likely alters 46 function of the osteogenic cells. This study highlights altered osteogenic differentiation 47 as a possible mechanism for causing the bone pathology observed in CHIKV 48 pathogenesis. 49Keywords 50 Chikungunya virus, mesenchymal stem cells, osteogenic differentiation 51Recent studies identified bone lesions in the joints of CHIKV infected mice, 65indicating that CHIKV can cause bone pathologies [12]. In another study, mice infected 66 with a similar arthritogenic alphavirus, Ross River virus (RRV) resulted in significant 67 bone loss [7]. In humans, magnetic resonance imaging (MRI) studies revealed that 68 CHIKV infection is associated with erosive arthritis [19]. Taken together these studies 69 suggest alphavirus infection can affect bone homeostasis and thus contribute to 70

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Chikungunya virus: clinical aspects and treatment - A Review

Cited by 169 publications

References 44 publications

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

Aspectos epidemiológicos da Chikungunya no Estado do Espírito Santo, Brasil, 2014 a 2017

Chikungunya virus infection impairs the function of osteogenic cells

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