Child reward neurocircuitry and parental substance use history: Findings from the Adolescent Brain Cognitive Development Study

Kwarteng, Amy; Rahman, Muhammad; Gee, Dylan G.; Infante, M. Alejandra; Tapert, Susan F.; Curtis, Brenda

doi:10.1016/j.addbeh.2021.107034

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…Unlike the present study, Kwarteng et al [ 11 ] found that FH+ youth had significantly greater activation in the right NAcc during anticipatory reward responding compared to FH- youth. This discrepancy may be due to differences in how FH+ groups were classified by Kwarteng et al [ 11 ] (e.g., binary FH+ versus FH- groups, FH+ youth having biological parents with at least two problems with alcohol). As in the present study, but in an older sample of young adults from the MLS, Yau et al [ 12 ] found decreased activation in the right NAcc in FH+ youth compared to FH- controls.…”

Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 92%

“…Our findings align, to a certain extent, with the prior literature showing differences between FH+ and FH- individuals specifically in the right NAcc [ 11 , 12 ]. Unlike the present study, Kwarteng et al [ 11 ] found that FH+ youth had significantly greater activation in the right NAcc during anticipatory reward responding compared to FH- youth. This discrepancy may be due to differences in how FH+ groups were classified by Kwarteng et al [ 11 ] (e.g., binary FH+ versus FH- groups, FH+ youth having biological parents with at least two problems with alcohol).…”

Section: Discussionsupporting

confidence: 92%

“…In an attempt to understand the mechanisms underlying familial vulnerability to AUD, a number of studies have investigated reward-related brain functioning [ 10 , 11 , 12 , 13 , 14 ]. The monetary incentive delay (MID) task is often used to measure the anticipation and receipt of rewards and losses [ 15 ], with the nucleus accumbens (NAcc) showing robust activation during the anticipation of rewards [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, previous neuroimaging studies using the MID task to examine associations between reward responding and FH of substance use have yielded inconsistent results. Kwarteng et al [ 11 ] found enhanced anticipatory reward activation in the right NAcc, whereas other studies have found no differences in anticipatory reward activation between FH+ and FH- youth [ 14 , 19 , 20 ]. The findings from Andrews et al [ 21 ] showed that FH+ adults with a father with AUD and at least one other first- or second-degree relative with AUD had blunted NAcc activation during reward anticipation examined through an MID task.…”

Section: Introductionmentioning

confidence: 99%

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Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

et al. 2022

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Having a family history of alcohol use problems (FH+) conveys risk for alcohol use in offspring. Reward-related brain functioning may play a role in this vulnerability. The present study investigated brain function in the nucleus accumbens (NAcc) associated with the anticipation of reward in youth with two biological parents with alcohol use problems (FH+2), one biological parent with alcohol use problems (FH+1), and no biological parents with alcohol use problems (FH-). Participants were from the large, national Adolescent Brain Cognitive Development (ABCD) Study (mean age: 9.93; 48% female; FH+2 n = 223, FH+1 n = 1447, FH- n = 9690) and the Michigan Longitudinal Study (MLS), consisting of community-recruited families with high rates of alcohol use disorder (mean age: 10.54; 39.3% female; FH+2 n = 40, FH+1 n = 51, FH- n = 40). Reward anticipation was measured by the monetary incentive delay task. Regression models were used to assess associations between FH status and the anticipation of large rewards in right and left NAcc regions of interest. In both studies, FH+2 youth showed blunted anticipatory reward responding in the right NAcc compared to FH+1 youth. In the MLS, FH+2 youth also had blunted anticipatory reward responding in the right NAcc compared to the FH- group. Convergent results across two separate samples provide insights into a unique vulnerability of FH+2 youth and suggest that binary FH+ versus FH- categorizations may obscure important differences within FH+ youth.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

et al. 2022

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Family history of substance use disorder and likelihood of prescription drug misuse in adults 50 and older

Schepis

Wastila

McCabe

2022

Aging & Mental Health

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Neural correlates associated with a family history of alcohol use disorder: A narrative review of recent findings

Cservenka,

Azma

2024

Alcohol, Clinical and Experimental Research

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A family history of alcohol use disorder (AUD) is associated with a significantly increased risk of developing AUD in one's lifetime. The previously reviewed literature suggests there are structural and functional neurobiological markers associated with familial AUD, but to our knowledge, no recent review has synthesized the latest findings across neuroimaging studies in this at‐risk population. For this narrative review, we conducted keyword searches in electronic databases to find cross‐sectional and longitudinal studies (2015‐present) that used magnetic resonance imaging (MRI), diffusion tensor imaging, task‐based functional MRI (fMRI), and/or resting state functional connectivity MRI. These studies were used to identify gray matter, white matter, and brain activity markers of risk and resilience in family history positive (FHP) individuals with a family history of AUD. FHP individuals have greater early adolescent thinning of executive functioning (frontal lobe) regions; however, some studies have reported null effects or greater gray matter volume and thickness relative to family history negative (FHN) peers without familial AUD. FHP individuals also have white matter microstructure alterations, such as reduced integrity of fronto‐striatal pathways. Recent fMRI studies have found greater inhibitory control activity in FHP individuals, while reward‐related findings are mixed. A growing interest in identifying intrinsic connectivity differences between FHP and FHN individuals has emerged in recent years. Familial AUD is related to both structural and functional brain alterations. Research should continue to focus on (1) longitudinal analyses with larger samples, (2) assessment of personal substance use and prenatal exposure to alcohol, (3) the effects of comorbid familial psychopathology, (4) examination of sex‐specific markers of risk and resilience, (5) neural predictors of alcohol use initiation, and (6) brain–behavior relationships. These efforts would aid the design of neurobiologically informed prevention and intervention efforts focused on this at‐risk population.

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Child reward neurocircuitry and parental substance use history: Findings from the Adolescent Brain Cognitive Development Study

Cited by 5 publications

References 24 publications

Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

Family history of substance use disorder and likelihood of prescription drug misuse in adults 50 and older

Neural correlates associated with a family history of alcohol use disorder: A narrative review of recent findings

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