Childhood and adolescent predictors of schizophrenia in the Northern Finland 1966 Birth Cohort – a descriptive life-span model

Isohanni, Matti; Jones, Peter B.; Kemppainen, Liisa; Croudace, Tim; Isohanni, Irene; Veijola, Juha; Räsänen, Sami; Wahlberg, Karl‐Erik; Tienari, Pekka; Rantakallio, Paula

doi:10.1007/s004060070006

Cited by 64 publications

(31 citation statements)

References 78 publications

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“…19 A study involving 61 patients with schizophrenia onsets before 18 years of age, showed a rate of enuresis of 36%.20 This approximates the present study's enuresis rate of 17% (2 out of the 12). In the National Institute of Mental Health (NIMH) study there was no evidence of increased obstetric complications or environmental stress.…”

Section: Discussionsupporting

confidence: 67%

Clinical characteristics and premorbid variables in childhoodonset schizophrenia: a descriptive study of twelve cases from a schizophrenia founder population

Maydell

Walt²,

Roos³

et al. 2009

Afr. J. Psych

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IntroductionThe study of phenotypic extremes with an early-onset has been an important approach to the understanding of disease across all medical disciplines. 1 In different medical illnesses, the combination of greater severity, relative treatment resistance, greater heritability and earlier age of onset has been observed. 2 In Alzheimer's disease and breast cancer, important molecular genetic discoveries have been observed in subpopulations with an earlier age of illness onset. 3,4 Most cases of schizophrenia have their onset in late adolescence and early adulthood, but the disorder has been identified in children since early in the 20th century. 5 The nosological status of schizophrenia in children was controversial for many years, however the landmark studies by Kolvin and colleagues clearly differentiated schizophrenia with onset in childhood from autistic disorder. 6 Since 1990, a study of childhood-onset schizophrenia (onset of schizophrenia at the age of 12 or younger) has been ongoing at the National Institute of Mental Health (NIMH). 7 This study shows clear and consistent clinical and biological continuity between childhood-and adult-onset schizophrenia. To analyze clinical and demographic data of childhood-onset (12 years and younger) schizophrenia patients collected for a genetic study in schizophrenia, undertaken nationally in South Africa, using multiple parameters. Method: Patients with an onset of schizophrenia at 12 years or younger, were included. From the Diagnostic Interview for Genetic Studies (DIGS), patients' information and summary report data was tabulated and analyzed. Specific subgroups were further compared. This sub-population of 12 subjects was further compared with a group of the adult sample. Results: Of the 12 patients recruited, prominent results were: male to female ratio of 1:1; all had insidious onset of psychosis; a third had all 3 multidimensional impairment (MDI) symptoms; all patients that received ADHD treatment had ADHD treatment failure; two thirds had milestone delay; 58% had birth complications; a third were predominantly bottle fed; 42% had family history of schizophrenia; a third had family history of other major psychiatric conditions; all patients had at least one non-psychotic deviant behaviour (NPDB); no patient used cannabis; all delusions were paranoid; 92% had school achievement difficulty and a third had treatment resistance. Gender comparison included: earlier onset of psychosis in females; all females had aggression versus a third of males; more females had school achievement difficulty than males; males had more treatment resistance. Patients with MDI, compared to the sample average had: earlier onset of non-psychotic deviant behaviour; lower school drop-out rate; less social difficulty and no treatment resistance. Conclusion:The results compare well to previous research on this topic. The new concepts introduced by the present study require further investigation.

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Section: Discussionsupporting

confidence: 67%

Clinical characteristics and premorbid variables in childhoodonset schizophrenia: a descriptive study of twelve cases from a schizophrenia founder population

Maydell

Walt²,

Roos³

et al. 2009

Afr. J. Psych

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“…6,20 It is well known that mental disorders in pregnant women may also alter the mother-fetus relationship and the future development of the child, which may be perceived in the newborn initially as excessive crying, irritability, or apathy, and may lead to affective disorders in adult age. [8][9][10] Multiprofessional care with pregnant women must encompass the interactions between a range of different factors. These include personal history, gynecological and obstetrical history, the timing of pregnancy within the woman's history, current social, cultural, and economic characteristics, and the quality of available care.…”

Section: Methodsmentioning

confidence: 99%

Atuação multiprofissional e a saúde mental de gestantes

et al. 2005

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ObjectiveTo identify non-psychotic affective disorders in pregnant women, to intervene by means of psychoprophylactic groups, and to evaluate possible alterations following intervention. Methods One-hundred and three pregnant women (71 adults and 32 adolescents) were seen at a community program in the Paraisópolis neighborhood in the city of Sao Paulo, southeastern Brazil. We used the following instruments: Self Reporting Questionnaire and Beck Depression Inventory. Ten weekly two-hour meetings were held, addressing the link between mother and fetus and subjects related to mother and child, and answering mother's doubts. We used the chi-squared test (χ 2 ) to compare mental health before and after the intervention, with a significance level of p<0.05. Results Affective disorders were found in 45 pregnant women (43.7%) before the intervention and in 23 (22.3%) after the intervention. The impact of the intervention on affective disorders was statistically significant (p=0.001). Twenty-one women (20.4%) showed depression before the intervention, and 13 (12.6%) after the intervention, a nonsignificant difference (p=0.133). Conclusions Multiprofessional care can prevent, detect, and treat affective disorders during pregnancy in both adults and adolescents. lated to family, marital relationship, society, culture, and the mother's personality.

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“…Numerous studies of premorbid function have revealed abnormalities or developmental delays in neuromotor, cognitive, language, emotional or social functioning. (McNeil et al, 2000;Isohanni et al, 2000a;Jones, 2001;Fuller et al, 2002;Cannon et al, 2003). Jones et al (1994) studied the British 1946 birth cohort and found evidence of delayed motor and speech development by the age of 2 years in those children who developed schizophrenia as adults.…”

Section: Introductionmentioning

confidence: 99%

The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life. A 34-year follow-up of the Northern Finland 1966 birth cohort

Isohanni

Murray

Jokelainen

et al. 2004

Schizophrenia Research

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SUMMARYChildhood precursors of schizophrenia include multiple abnormalities of development.Continuities between early and subsequent deviance are poorly characterised. We studied associations among premorbid developmental deviance using data at ages 1 year (learning to stand, walk, and speak, attainment of bladder and bowel control) and 16 years (success at school). Generalised linear modelling was used to examine differential linear associations and trends across adult psychiatric diagnoses. In babies who, as adults, suffered schizophrenia or any psychosis, those who learned to stand latest were also more likely to perform poorly at school in both motor and theoretical domains at age 16 when compared with earlier learners. The effect was independent of genetic and perinatal factors. We conclude that the early developmental deviation in the first year of life is associated with lower school performance at age 16. Developmental continuity among children who develop psychoses was stronger than among normal controls and those hospitalised for non-psychotic psychiatric disorder. These findings are in line with hypothesis that a neural diathesis is present during postnatal brain development before schizophrenia. This supports the longitudinal dimension and life span models of schizophrenia.

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Childhood and adolescent predictors of schizophrenia in the Northern Finland 1966 Birth Cohort – a descriptive life-span model

Cited by 64 publications

References 78 publications

Clinical characteristics and premorbid variables in childhoodonset schizophrenia: a descriptive study of twelve cases from a schizophrenia founder population

Clinical characteristics and premorbid variables in childhoodonset schizophrenia: a descriptive study of twelve cases from a schizophrenia founder population

Atuação multiprofissional e a saúde mental de gestantes

The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life. A 34-year follow-up of the Northern Finland 1966 birth cohort

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