Childhood asthma and risk factors

Ljustina-Pribic, Radmila; Petrovic, Slobodanka; Tomić, Jelena

doi:10.2298/mpns1008516l

Cited by 3 publications

(8 citation statements)

References 39 publications

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“…Bronchial asthma is the most common chronic childhood disease in developed countries. Its prevalence has nearly doubled over the last 2 decades, putting a serious socio-economic burden on the children and their families [2]. The pathogenesis of bronchial asthma is based on the interaction between multiple genetic and environmental factors [3].…”

Section: Introductionmentioning

confidence: 99%

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Developmental regulation of inflammatory cytokine-mediated Stat3 signaling: the missing link between intrauterine growth restriction and pulmonary dysfunction?

et al. 2012

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Intrauterine growth restriction (IUGR) is a risk factor for impairment of lung function in adolescence and adulthood. Inflammatory and proliferative processes linking IUGR and perturbed extracellular matrix (ECM) as an underlying mechanism have not been addressed so far. Therefore, in this study, we aimed to investigate the developmental regulation of inflammatory and profibrotic processes in the lung subsequent to IUGR. IUGR was induced in rats by isocaloric protein restriction during gestation. Lung function was assessed with direct plethysmography at postnatal day (P) 28 and P70. Lungs were obtained at P1, P42, and P70 for assessment of mRNA, protein expression, immunohistochemistry, and gelatinolytic activity. Both respiratory system resistance and compliance were impaired subsequent to IUGR at P28 and this impairment was even more pronounced at P70. In line with these results, the expression of ECM components and metabolizing enzymes was deregulated. The deposition of collagen was increased at P70. In addition, the expression of inflammatory cytokines and both the activity and the expression of target genes of Stat3 signaling were dynamically regulated, with unaltered or decreased expression at P1 and significantly increased expression art P70. Taken together, these data give evidence for an age-dependent impairment of lung function as a result of a developmentally regulated increase in inflammatory and profibrotic processes subsequent to IUGR.

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Section: Introductionmentioning

confidence: 99%

“…In this study, we tested the hypothesis that IUGR (1) impairs lung function in a time dependent manner, (2) deregulates both, the expression of profibrotic markers and formation and remodeling of the ECM, and (3) has an impact on pulmonary inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Developmental regulation of inflammatory cytokine-mediated Stat3 signaling: the missing link between intrauterine growth restriction and pulmonary dysfunction?

et al. 2012

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“…Alergijska oboljenja kod djece postaju jedan od vodećih zdravstvenih, socijalnih i ekonomskih problema u svijetu. [1][2][3] Porast prevalencije ovih oboljenja kod djece koji je zapažen zadnjih 30-tak godina značajno opterećuje i zdravstvene sisteme, posebno zemalja u razvoju. 1 Kvalitet života djece sa simptomima astme, alergijskog rinitisa ili ekcema značajno je smanjen posebno imajući na umu da ova alergijska oboljenja često imaju komorbiditet.…”

Section: Uvodunclassified

“…[1][2][3] Porast prevalencije ovih oboljenja kod djece koji je zapažen zadnjih 30-tak godina značajno opterećuje i zdravstvene sisteme, posebno zemalja u razvoju. 1 Kvalitet života djece sa simptomima astme, alergijskog rinitisa ili ekcema značajno je smanjen posebno imajući na umu da ova alergijska oboljenja često imaju komorbiditet. 1,4,5 U pojedinim regionima uočen je dramatičan porast učestalosti alergijskih oboljenja, međutim tačan model kretanja prevalencije alergijskih oboljenja kod djece još nije jasno utvrđen.…”

Section: Uvodunclassified

“…1 Kvalitet života djece sa simptomima astme, alergijskog rinitisa ili ekcema značajno je smanjen posebno imajući na umu da ova alergijska oboljenja često imaju komorbiditet. 1,4,5 U pojedinim regionima uočen je dramatičan porast učestalosti alergijskih oboljenja, međutim tačan model kretanja prevalencije alergijskih oboljenja kod djece još nije jasno utvrđen. 6,7 Značajan porast prevalencije simptoma alergijskih oboljenja kod djece djelimično je povezan i sa promjenama u načinu života i većem stepenu urbanizacije.…”

Section: Uvodunclassified

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Prevalencija simptoma alergijskih oboljenja kod djece školskog uzrasta u Republici Srpskoj

Vujnović¹,

Domuz²,

Petrovic³

2017

rsp

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SAŽETAK: Naša studija je prva ovakva studija koja koristi internacionalnu metodologiju za određivanje prevalencije alergijskih oboljenja kod školske djece. Cilj ove studije bio je odrediti prevalenciju i geografske varijacije simptoma alergijskih oboljenja kod djece školskog uzrasta na teritoriji Republike Srpske. Istraživanje je provedeno u obliku studije presjeka i obuhvatalo je 3000 djece iz 13 osnovnih škola. Prevalencija simptoma alergijskih oboljenja određivala se putem upitnika Internacionalne studije za astmu i alergije kod djece (The International Study of Asthma and Allergies in Childhood-ISAAC). Prevalencija vizing u poslednjih 12 mjeseci u Republici Srpskoj bila je 7,95%, ekcema 5,01% i simptoma alergijskog rinokonjuktivitisa 12,71%. Simptomi astme najčešće su prisutni kod djece uzrasta od 8 do 10 godina. Prevalencija simptoma ekcema i alergijskog rinitisa ima tendenciju rasta do 9. odnosno 10. godine uzrasta djeteta, poslije čega se uočava pad učestalosti ovih simptoma. Rezultati multicentričnih studija pokazuju da su zemlje u razvoju, kao što je naša, u posebnom riziku za veću učestalost simptoma alergijskih oboljenja kod djece. Stoga je važno provoditi epidemiološke studije o prevalenciji ovih oboljenja, posebno imajući na umu uticaj ovih oboljenja na kvalitet života djece.

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Nutritional status (BMI) in children suffering from asthma

Scepanovic¹,

Perovic²,

Božić-Krstić³

2013

Arch biol sci (Beogr)

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The research encompassed 708 children of both genders, aged 6 to 15. Three hundred and fifty four of the total number had been diagnosed with Asthma bronchiale, whereas the other half of the children were healthy and served as a control group. Their nutritional condition was determined on the basis of the percentile value of their BMI. Recent studies on the level of nutrition and its connection to asthma have shown contradictory results. This paper was aimed at estimating the nutritional level of sick children in relation to healthy ones. The data were analyzed in relation to group, gender and age by means of descriptive methods, univariate (analysis of variance - ANOVA) and multivariate (multivariate analysis of variance - MANOVA), whereas the results were tested by Roy’s test (Pearson contingency coefficient χ, coefficient of multiple correlation R). It was determined that male children more frequently suffer from this disease than female children do. Both healthy and sick children were normally nourished. However, as regards the sick, the number of normally nourished was considerably lower, whereas the number of underweight was considerably higher, as well as those that were overweight. Intergroup differences in the distribution of certain levels of nutrition of male and female children occurred in only two non-sequential age groups, being later in boys than in girls. This uneven distribution is probably a consequence of the joint effects of environment factors, sickness and therapy

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Childhood asthma and risk factors

Abstract: The development of asthma as well as its severity are affected by numerous factors and their interactions can he explained by the heterogeneous nature of this disease.

Cited by 3 publications

References 39 publications

Developmental regulation of inflammatory cytokine-mediated Stat3 signaling: the missing link between intrauterine growth restriction and pulmonary dysfunction?

Developmental regulation of inflammatory cytokine-mediated Stat3 signaling: the missing link between intrauterine growth restriction and pulmonary dysfunction?

Prevalencija simptoma alergijskih oboljenja kod djece školskog uzrasta u Republici Srpskoj

Nutritional status (BMI) in children suffering from asthma

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