2001
DOI: 10.1007/s004310100809
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Childhood asthma as an allergic disease: rationale for the development of future treatment

Abstract: As we further understand the pathophysiology of asthma, the potential to develop novel treatments increases. This paper addresses current possible new treatments for the future.

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Cited by 6 publications
(3 citation statements)
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“…These studies combined suggest that a successful vaccine may be designed by either encapsulating the antigen inside of the particle or by adsorbing the antigen on to the surface of the particle. The shift in Th2-type response to Th1-dominant immunity during early disease has been shown to prevent allergic inflammatory responses and lung remodeling (52,53). In this study, analysis of BAL fluids (Fig.…”
Section: Discussionmentioning
confidence: 84%
“…These studies combined suggest that a successful vaccine may be designed by either encapsulating the antigen inside of the particle or by adsorbing the antigen on to the surface of the particle. The shift in Th2-type response to Th1-dominant immunity during early disease has been shown to prevent allergic inflammatory responses and lung remodeling (52,53). In this study, analysis of BAL fluids (Fig.…”
Section: Discussionmentioning
confidence: 84%
“…Clinical manifestations are episodic wheezing, dyspnea, coughing, sputum production, and bronchoconstriction [1,2]. It is estimated that as many as 300 million individuals suffer from asthma worldwide [3,4].…”
Section: Introductionmentioning
confidence: 99%
“…Asthma is a one of the most common pediatric diseases and is characterized by eosinophilic airway inflammation, reversible airway obstruction, hyperresponsiveness and airway remodeling (1,2). The prevalence of asthma is increasing in most countries (3,4).…”
Section: Introductionmentioning
confidence: 99%