Childhood Bereavement and Type 1 Diabetes: a <scp>D</scp>anish National Register Study

Virk, Jasveer; Ritz, Beate; Li, Jiong; Obel, Carsten; Olsen, Jørn

doi:10.1111/ppe.12247

Cited by 11 publications

(11 citation statements)

References 45 publications

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“…Our null findings differ from findings in children . Arguably, LADA is a less autoimmune form of diabetes, which may explain why the results were different.…”

Section: Discussioncontrasting

confidence: 99%

“…Results were consistent in men and women, and for the different events investigated. Our null findings differ from findings in children [1][2][3][4][5][6][7][8]. Arguably, LADA is a less autoimmune form of diabetes, which may explain why the results were different.…”

Section: Discussioncontrasting

confidence: 99%

“…It has been suggested that psychological stress, including experience of serious life events, increases the risk of Type 1 diabetes . Studies in adults are scarce, but Littorin et al .…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that psychological stress, including experience of serious life events, increases the risk of Type 1 diabetes [1][2][3][4][5][6][7][8]. Studies in adults are scarce, but Littorin et al did not find a positive association between life events and Type 1 diabetes diagnosed between age 15 and 34 [9].…”

Section: Introductionmentioning

confidence: 99%

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Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes

et al. 2017

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“…Our null findings differ from findings in children . Arguably, LADA is a less autoimmune form of diabetes, which may explain why the results were different.…”

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

“…It has been suggested that psychological stress, including experience of serious life events, increases the risk of Type 1 diabetes . Studies in adults are scarce, but Littorin et al .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes

et al. 2017

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“…Most studies of bereaved siblings’ morbidity and mortality have been conducted on adolescents and adults who lost a sibling using national data sets from Sweden and Denmark. Virk et al (2016), using the Danish Civil Registry System, found evidence of an increase in the rate of type 1 diabetes among the more than 94,000 children exposed to bereavement through loss of a sibling (5 years or greater). Lu et al (2016) studied the risk of human papilloma virus (HPV) infection and cervical cancer in over 2 million women in Sweden and found bereavement was associated with a 62% increased risk of HPV16 infection, high viral load and recurrent infection.…”

Section: Introductionmentioning

confidence: 99%

Surviving Siblings’ Illnesses, Treatments/Health Services over 13 Months after a Sibling’s Death

et al. 2018

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Two million children experience sibling death annually and have problems that require clinical intervention although few receive such help. Effects on surviving siblings’ mental health has been well documented, however their physical health has not. This study described surviving siblings’ illnesses, treatments/health services at 2, 4, 6, and 13 months post-sibling death. The 132 children (76 girls, 56 boys, M 10.6 years, SD 3.43); 30% Hispanic, 51% Black, 26% White were recruited via hospital ICUs and published obituaries. Using a longitudinal design, parents reported types and numbers of surviving siblings’ illnesses, treatments/health services, and dates post-sibling death. Most of the 207 illnesses and 674 treatments/health services occurred in the first 6 months post-sibling death. While girls had more illnesses (131) than boys (76) and Hispanic children had more illnesses than White or Black children, these differences were not statistically significant. Girls accounted for 66% of the treatments/health services and boys 34%. There was no significant difference in treatments/health service use by gender of the children (F = 1.00, p = .32). Hispanic children had significantly more treatments/health service use than Black children (F = 6.81, p = .002). Sibling death affects surviving siblings’ physical health. Study data document the importance of monitoring the health, treatments and health service use of surviving siblings especially in the first 6 months after a sibling death, regardless of the child’ s gender. On average, Hispanic children had greater health service use, which may warrant greater attention.

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Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden

Wernroth,

Kennedy,

Fall

et al. 2024

Diabetologia

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Aims/hypothesis The potential impact of childhood bereavement—a severe psychological stressor—on childhood type 1 diabetes development remains unclear. Here, we aimed to bridge this knowledge gap and assess whether bereavement characteristics influenced any impact. Methods We conducted a register-based cohort study encompassing 3,598,159 children born in Sweden between 1987 and 2020. Childhood bereavement was defined as the death of a biological mother, father or sibling. Diagnosis of type 1 diabetes in childhood (<18 years) was ascertained through the National Patient Register. We applied a Cox proportional hazards regression model to investigate the impact of childhood bereavement on type 1 diabetes, while adjusting for potential confounders (including parental type 1 diabetes status, country of birth and demographic characteristics). Results During follow-up, 86,226 children (2.4%) lost a family member, and 18,817 children (0.52%) were diagnosed with type 1 diabetes (median age at onset 9.1 years). We did not detect any overall association between childhood bereavement and type 1 diabetes (adjusted HR 1.04; 95% CI 0.93, 1.17). We found no influence of age at loss, cause of death, familial relationship to the deceased, and time since loss. Conclusions/interpretation In this large population-based Swedish study, we observed no evidence supporting a link between childhood bereavement and type 1 diabetes. Graphical Abstract

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Childhood Bereavement and Type 1 Diabetes: a Danish National Register Study

Abstract: We found some evidence to indicate an increase in the rate of type 1 diabetes among children exposed to bereavement when exposure occurred after 11 years of age.

Cited by 11 publications

References 45 publications

Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes

Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes

Surviving Siblings’ Illnesses, Treatments/Health Services over 13 Months after a Sibling’s Death

Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden

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