Serious life events and the risk of latent autoimmune diabetes in adults (<scp>LADA</scp>) and Type 2 diabetes

Rasouli, Bahareh; Andersson, Tomas; Carlsson, P-O; Hjort, Rebecka; Löfvenborg, Josefin E.; Martinell, Mats; Groop, Leif; Tuomi, Tiinamaija; Carlsson, Sofia

doi:10.1111/dme.13410

Cited by 10 publications

(10 citation statements)

References 20 publications

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“…Rasouli et al . found no significant association between experience of any specific serious life events and type 2 diabetes risk in older people. As for sex, however, a similar trend was not found on both sides, and we suggested that the significant associations shown in men and women varied in the types of life events experienced.…”

Section: Discussioncontrasting

confidence: 44%

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Associations between stressful life events and diabetes: Findings from the China Kadoorie Biobank study of 500,000 adults

Wang

Gong

et al. 2019

J of Diabetes Invest

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Aims/Introduction Evidence has shown that stressful life events are associated with the development of diabetes, yet studies in mainland China are scarce. In the present study, we explored the associations between cumulative and specific stressful life events and the prevalence of diabetes in Chinese adults. Materials and Methods The cross‐sectional data were from the China Kadoorie Biobank study, which enrolled approximately 500,000 adults aged 30–79 years from 10 diverse regions of China. Logistic regression models were used to calculate the adjusted odds ratio (OR) and the 95% confidence interval (CI). Results Of the 473,607 participants, 25,301 (5.34%) had type 2 diabetes (2.68% clinically‐identified and 2.66% screen‐detected). Participants who experienced one and two or more stressful life events were 1.10‐fold (OR 1.10, 95% CI 1.05–1.16) and 1.33‐fold (OR 1.33, 95% CI 1.13–1.57) more likely to have type 2 diabetes. Three categories of work‐related events (OR 1.15, 95% CI 1.01–1.31), as well as family‐related events (OR 1.11, 95% CI 1.06–1.18) and personal‐related events (OR 1.18, 95% CI 1.03–1.36), were associated with an increased likelihood of type 2 diabetes. Regarding the specific life events, the ORs of loss of job or retirement, as well as major conflict within family, death or major illness of other close family member and major injury or traffic accident, were 1.24 (95% CI 1.02–1.52), 1.24 (95% CI 1.08–1.43), 1.13 (95% CI 1.06–1.20) and 1.20 (95% CI 1.01–1.43), respectively. Conclusions The present study showed that cumulative and specific stressful life events were significantly associated with an increased prevalence of diabetes.

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Section: Discussioncontrasting

confidence: 44%

“…For example, a recent case–control study by Rasouli et al . pointed out that there was no association between experience of any specific serious life events and type 2 diabetes risk. Also, the Whitehall II study showed non‐significant associations of the number of non‐work life events with incident diabetes in both sexes.…”

Section: Introductionmentioning

confidence: 97%

Associations between stressful life events and diabetes: Findings from the China Kadoorie Biobank study of 500,000 adults

Wang

Gong

et al. 2019

J of Diabetes Invest

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“…What triggers autoimmunity besides genetic factors is not clear; Psychological stress has been linked to type 1 diabetes in children (Rewers and Ludvigsson, 2016) but no such association was seen with LADA (Rasouli et al, 2017b). In line with some findings regarding type 1 diabetes in children (Stene et al, 2003; Norris et al, 2007; Niinistö et al, 2017), fatty fish is associated with a reduced risk of LADA but unrelated to type 2 diabetes in the ESTRID Study (Löfvenborg et al, 2014).…”

Section: Etiologymentioning

confidence: 99%

Etiology and Pathogenesis of Latent Autoimmune Diabetes in Adults (LADA) Compared to Type 2 Diabetes

Carlsson

2019

Front. Physiol.

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As the heterogeneity of diabetes is becoming increasingly clear, opportunities arise for more accurate assessment of factors influencing disease onset, which may lead to more efficient primary prevention. LADA – latent autoimmune diabetes in adults – is a common, hybrid form of diabetes with features of both type 1 and type 2 diabetes. This review aims to summarize current knowledge on the pathophysiological and etiological overlap and differences between LADA and type 2 diabetes, discuss similarities between LADA and type 1 diabetes and point at future research needs. Studies conducted to date show a clear genetic overlap between LADA and type 1 diabetes with a high risk conferred by variants in the human leukocyte antigen (HLA) region. In contrast, data from the limited number of studies on lifestyle factors available indicate that LADA may share several environmental risk factors with type 2 diabetes including overweight, physical inactivity, alcohol consumption (protective) and smoking. These factors are known to influence insulin sensitivity, suggesting that insulin resistance, in addition to insulin deficiency due to autoimmune destruction of the beta cells, may play a key role in the pathogenesis of LADA. Moreover, this implies that onset of LADA, similar to type 2 diabetes, to some extent could be prevented or postponed by lifestyle modification such as weight reduction and increased physical activity. The preventive potential of LADA is an important topic to elucidate in future studies, preferably intervention studies.

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“…One cross-sectional study reported a positive association between stressful life events and prevalence of undiagnosed diabetes (Mooy, de Vries, Grootenhuis, Bouter, & Heine, 2000). Two other studies [one case-control study (Rasouli et al, 2017) and another a prospective study (Kumari, Head, & Marmot, 2004)] reported weak or no association.…”

mentioning

confidence: 99%

Social Relationships and Risk of Type 2 Diabetes Among Postmenopausal Women

Hendryx

Nicholson

Manson

et al. 2019

The Journals of Gerontology: Series B

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Objectives We examined whether social relationship variables (social support, social strain, social network size, and stressful life events) were associated with risk of developing type 2 diabetes among postmenopausal women. Method 139,924 postmenopausal women aged 50–79 years without prevalent diabetes at baseline were followed for a mean of 14 years. 19,240 women developed diabetes. Multivariable Cox proportional hazard models tested associations between social relationship variables and diabetes incidence after consideration of demographics, depressive symptoms, and lifestyle behaviors. We also examined moderating effects of obesity and race/ethnicity, and we tested whether social variable associations were mediated by lifestyle or depressive symptoms. Results Compared with the lowest quartile, women in the highest social support quartile had lower risk of diabetes after adjusting for demographic factors, health behaviors, and depressive symptoms (hazard ratio [HR] = 0.93, 95% confidence interval [CI] = 0.89–0.97). Social strain (HR = 1.09, 95% CI = 1.04–1.13) and stressful life events (HR = 1.10, 95% CI = 1.05–1.15) were associated with higher diabetes risks. The association between diabetes and social strain was stronger among African American women. Social relationship variables had direct relationships to diabetes, as well as indirect effects partially mediated by lifestyle and depressive symptoms. Discussion Social support, social strain, and stressful life events were associated with diabetes risk among postmenopausal women independently of demographic factors and health behaviors. In addition to healthy behaviors such as diet and physical activity, healthy social relationships among older women may be important in the prevention of diabetes.

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Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes

Abstract: Our findings indicate that experience of a serious life event, including the death of a family member, divorce or financial problems, is not associated with an increased risk of LADA, overall or in genetically susceptible individuals.

Cited by 10 publications

References 20 publications

Associations between stressful life events and diabetes: Findings from the China Kadoorie Biobank study of 500,000 adults

Associations between stressful life events and diabetes: Findings from the China Kadoorie Biobank study of 500,000 adults

Etiology and Pathogenesis of Latent Autoimmune Diabetes in Adults (LADA) Compared to Type 2 Diabetes

Social Relationships and Risk of Type 2 Diabetes Among Postmenopausal Women

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