Childhood Blood Lead Levels and Symptoms of Attention Deficit Hyperactivity Disorder (ADHD): A Cross-Sectional Study of Mexican Children

Huang, Siying; Hu, Howard; Sánchez, Brisa N.; Peterson, Karen E.; Ettinger, Adrienne S.; Lamadrid‐Figueroa, Héctor; Schnaas, Lourdes; Mercado‐García, Adriana; Wright, Robert O.; Basu, Niladri; Cantonwine, David E.; Hernández-Ávila, Mauricio; Téllez-Rojo, Martha M.

doi:10.1289/ehp.1510067

Cited by 83 publications

(49 citation statements)

References 58 publications

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“…It was noticed that lead level had insignificant differences between different grades of ADHD symptoms. This result is agreed with (Huang et al,2016) who noticed that there is an association between lead and symptoms of ADHD when blood lead was ≤ 5 μg/dl. However, this association was decreased when levels were > 5 μg/dL, which may explain why behavior problems are not often correlated with lead exposure.…”

Section: Discussionsupporting

confidence: 92%

Lead as a Risk Factor for Attention Deficit Hyperactivity Disorder (ADHD) in Children.

Awaga

Hamed

Hammad

et al. 2020

Zagazig Journal of Forensic Medicine

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Background: Attention Deficit Hyperactivity Disorder (ADHD) is considered one of the most common childhood psychiatric disorders. The worldwide prevalence is approximately 5%. In Egypt, exposure of children to heavy metal is considered one of the risk factors lead to ADHD. The aim of this study was to investigate the potential association between lead exposure and ADHD in children and find the association between the level of exposure to lead and degree of ADHD symptoms. Method: Case control study was done by random selection of children from outpatient Clinic at Assiut University Hospital of Children. Data were collected by a questionnaire to evaluate environmental exposure to lead and blood analysis for this heavy metal level. Results: Lead level in ADHD children was significantly higher than control (20.88± 7.47 ug/dl versus 16.13 ± 7.91 ug/dl). While there is no significant difference between lead level and degree of symptoms among the ADHA children. In conclusion, there is a significant association between ADHD in the examined sample of children and exposure to lead especially through water contamination with lead. Lead level is significant for reflecting exposure to lead.

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Section: Discussionsupporting

confidence: 92%

Lead as a Risk Factor for Attention Deficit Hyperactivity Disorder (ADHD) in Children.

Awaga

Hamed

Hammad

et al. 2020

Zagazig Journal of Forensic Medicine

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“…The most enriched element was Sb, which is consistent with the main traffic-related origin of cPM D . Another metal of concern is Pb, which is highly toxic and is enriched by 86 times in cPM D [ 36 , 37 ]. Both Sb and Pb concentrations were similar to those reported for other urban areas [ 30 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

et al. 2017

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BackgroundAir pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection. Our first aim was to collect urban coarse particulate matter (PM) and to characterize them for elemental content, gastric bioaccessibility, and oxidative potential; our second aim was to determine the short-term effects of urban coarse PM inhalation on pulmonary and colonic mucosae in mice, and to test the hypothesis that the well-known antioxidant N-acetyl-L-cysteine (NAC) reverses the effects of PM inhalation.ResultsThe collected PM had classical features of urban particles and possessed oxidative potential partly attributable to their metal fraction. Bioaccessibility study confirmed the high solubility of some metals at the gastric level. Male mice were exposed to urban coarse PM in a ventilated inhalation chamber for 15 days at a concentration relevant to episodic elevation peak of air pollution. Coarse PM inhalation induced systemic oxidative stress, recruited immune cells to the lung, and increased cytokine levels in the lung and colon. Concomitant oral administration of NAC reversed all the observed effects relative to the inhalation of coarse PM.ConclusionsCoarse PM-induced low-grade inflammation in the lung and colon is mediated by oxidative stress and deserves more investigation as potentiating factor for inflammatory diseases.Electronic supplementary materialThe online version of this article (10.1186/s12989-017-0227-z) contains supplementary material, which is available to authorized users.

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“…From 2008 to 2010, a subsample of 206 participants (from the original 631) participated in a research visit during adolescence at approximately 14-16 years of age. 22 In 2016, a young-adult visit (21-22 years of age) was conducted. 23 Of the 206 participants who attended the previous visit, 55 did not respond and 51 chose not to participate.…”

Section: Methodsmentioning

confidence: 99%

Overweight and obesity status from the prenatal period to adolescence and its association with non‐alcoholic fatty liver disease in young adults: cohort study

Cantoral

Montoya

Luna-Villa

et al. 2020

BJOG

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Objective To examine the associations of maternal and child overweight status across multiple time‐points with liver fat content in the offspring during young adulthood. Design Cohort study. Setting ELEMENT Cohort in Mexico City. Population Pregnant women with singleton births (n = 97). Methods We quantified hepatic triglyceride content (liver fat content) by proton magnetic resonance spectroscopy (1H MRS) and conventional T2‐weighted MRIs (3T scanner) in 97 young adults from the ELEMENT birth cohort in Mexico City. Historical records of the cohort were used as a source of pregnancy, and childhood and adolescence anthropometric information, overweight and obesity (OWOB) were defined. Adjusted structural equation models were run to identify the association between OWOB in different life stages with liver fat content (log‐transformed) in young adulthood. Main outcome Maternal OWOB at the time of delivery was directly and indirectly associated with the liver fat content in the offspring at young adulthood. Results Seventeen percent of the participants were classified as having NAFLD. We found a strong association of OWOB between all periods assessed. Maternal OWOB at time of delivery (β = 1.97, 95% CI 1.28–3.05), and OWOB status in the offspring at young adulthood (β = 3.17, 95% CI 2.10–4.77) were directly associated with the liver fat content in the offspring. Also, maternal OWOB was indirectly associated with liver fat content through offspring OWOB status. Conclusion We found that maternal OWOB status is related to fatty liver content in the offspring as young adults, even after taking into account OWOB status and lifestyle factors in the offspring. Tweetable abstract There was an association between pre‐pregnancy overweight and the development of NAFLD in adult offspring.

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Childhood Blood Lead Levels and Symptoms of Attention Deficit Hyperactivity Disorder (ADHD): A Cross-Sectional Study of Mexican Children

Cited by 83 publications

References 58 publications

Lead as a Risk Factor for Attention Deficit Hyperactivity Disorder (ADHD) in Children.

Lead as a Risk Factor for Attention Deficit Hyperactivity Disorder (ADHD) in Children.

Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

Overweight and obesity status from the prenatal period to adolescence and its association with non‐alcoholic fatty liver disease in young adults: cohort study

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