Childhood cancer incidence among specific Asian and Pacific Islander populations in the United States

Moore, Kristin J.; Hubbard, Aubrey K.; Williams, Lindsay A.; Spector, Logan G.

doi:10.1002/ijc.33153

Cited by 9 publications

(8 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We grouped broad racial and ethnic categories together, although recent reports have shown that incidence may vary within subpopulations of these large and diverse groups. 51 As noted above, although we presented unadjusted IRR estimates, these map closely to the odds ratios observed in previous work, which were adjusted for socioeconomic status proxies and known perinatal risk factors, 3 suggesting that unmeasured confounding is not likely to be a major driver of these observations. Last, we were unable to look at race-and ethnicity-specific trends by tumor subtype, such as ALL cytogenetic subtypes or solid tumor histologic subtypes, which should be explored in more detailed data sets.…”

Section: Discussionsupporting

confidence: 71%

“…Additionally, we did not have sufficient numbers of cases in the minority racial and ethnic groups to examine trends by single year of age. We grouped broad racial and ethnic categories together, although recent reports have shown that incidence may vary within subpopulations of these large and diverse groups 51 . As noted above, although we presented unadjusted IRR estimates, these map closely to the odds ratios observed in previous work, which were adjusted for socioeconomic status proxies and known perinatal risk factors, 3 suggesting that unmeasured confounding is not likely to be a major driver of these observations.…”

Section: Discussionmentioning

confidence: 74%

See 1 more Smart Citation

Racial and ethnic disparities in pediatric cancer incidence among children and young adults in the United States by single year of age

Marcotte

Domingues

Sample

et al. 2021

Cancer

Self Cite

View full text Add to dashboard Cite

BACKGROUND:Incidence rates of pediatric cancers in the United States are typically reported in 5-year age groups, obscuring variation by single year of age. Additionally, racial and ethnic variation in incidence is typically presented in broad categories rather than by narrow age ranges. METHODS: The Surveillance, Epidemiology, and End Results (SEER) 18 data (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017) were examined to calculate frequencies and age-adjusted incidence rates among individuals aged birth to 39 years. Incidence rate ratios (IRRs) and 95% confidence intervals (95% CIs) were estimated as the measure of association for rate comparisons by race and Hispanic origin overall and by single year of age. RESULTS: Several histologic types showed substantial variation in race/ethnicity-specific and overall rates by single year of age. Overall, Black children and young adults experienced substantially decreased incidence of acute lymphoid leukemia (IRR, 0.52; 95% CI, 0.49-0.55) compared to Whites, and this decreased incidence was strongest at ages 1 through 7 years and 16 through 20 years. Hispanic individuals experienced decreased overall incidence of Hodgkin lymphoma (IRR, 0.50; 95% CI, 0.48-0.52) and astrocytoma (IRR, 0.54; 95% CI, 0.52-0.56) and increased risk of acute lymphoblastic leukemia (IRR, 1.46; 95% CI, 1.42-1.51) compared to non-Hispanic Whites, and the increased risk was strongest at ages 10 through 23 years. Substantial decreased risk across many tumor types was also observed for Asian/Pacific Islanders and American Indian/Alaska Natives. CONCLUSIONS: Examination of incidence rates for pediatric cancers by narrow age groups may provide insights regarding etiological differences in subgroups. Additionally, variation in age-specific incidence rates by race and ethnicity may enable hypothesis generation on drivers of disparities observed.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 74%

Racial and ethnic disparities in pediatric cancer incidence among children and young adults in the United States by single year of age

Marcotte

Domingues

Sample

et al. 2021

Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Notably, the North American regions with Mexican, Canadian, and American populations display high incidence rates of AL (31.4–65.4) in comparison to other populations ( 2 , 3 , 8 – 10 , 72 , 78 – 81 ). Furthermore, studies in children of Hispanic ancestry, aged 0–19 years, have also shown incidence rates that are among the highest worldwide ( 7 , 11 , 82 – 89 ) ( Supplementary Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Persistently high incidence rates of childhood acute leukemias from 2010 to 2017 in Mexico City: A population study from the MIGICCL

Flores-Lujano

Duarte-Rodríguez

Jiménez‐Hernández

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

IntroductionOver the years, the Hispanic population living in the United States has consistently shown high incidence rates of childhood acute leukemias (AL). Similarly, high AL incidence was previously observed in Mexico City (MC). Here, we estimated the AL incidence rates among children under 15 years of age in MC during the period 2010–2017.MethodsThe Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia conducted a study gathering clinical and epidemiological information regarding children newly diagnosed with AL at public health institutions of MC. Crude age incidence rates (cAIR) were obtained. Age-standardized incidence rates worldwide (ASIRw) and by municipalities (ASIRm) were calculated by the direct and indirect methods, respectively. These were reported per million population <15 years of age; stratified by age group, sex, AL subtypes, immunophenotype and gene rearrangements.ResultsA total of 903 AL cases were registered. The ASIRw was 63.3 (cases per million) for AL, 53.1 for acute lymphoblastic leukemia (ALL), and 9.4 for acute myeloblastic leukemia. The highest cAIR for AL was observed in the age group between 1 and 4 years (male: 102.34 and female: 82.73). By immunophenotype, the ASIRw was 47.3 for B-cell and 3.7 for T-cell. The incidence did not show any significant trends during the study period. The ASIRm for ALL were 68.6, 66.6 and 62.8 at Iztacalco, Venustiano Carranza and Benito Juárez, respectively, whereas, other municipalities exhibited null values mainly for AML.ConclusionThe ASIRw for childhood AL in MC is among the highest reported worldwide. We observed spatial heterogeneity of rates by municipalities. The elevated AL incidence observed in Mexican children may be explained by a combination of genetic background and exposure to environmental risk factors.

show abstract

“…This disparity in ALL risk corresponds to what has been observed geographically. For instance, Latin American countries, including Mexico and Costa Rica, have some of the highest incidences of childhood ALL in the world [91,92] . Meanwhile, the highest incidence of childhood ALL in the United States is found in the West United States Census Region, where a high proportion of residents are Hispanics/Latinos [65] .…”

Section: Incidence Of All Is Highest In Hispanics/latinosmentioning

confidence: 99%

Disparities in acute lymphoblastic leukemia risk and survival across the lifespan in the United States of America

Xu¹,

Feng²,

Smith³

2021

jtgg

View full text Add to dashboard Cite

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer but is less frequent in adolescents and young adults (AYAs) and is rare among older adults. The 5-year survival of ALL is above 90% in children, but drops significantly in AYAs, and over half of ALL-related deaths occur in older adults. In addition to diagnosis age, the race/ethnicity of patients consistently shows association with ALL incidence and outcomes. Here, we review the racial/ethnic disparities in ALL incidence and outcomes, discuss how these vary across the age spectrum, and examine the potential causes of these disparities. In the United States, the incidence of ALL is highest in Hispanics/Latinos and lowest in Black individuals across all age groups. ALL incidence is rising fastest in Hispanics/Latinos, especially in AYAs. In addition, survival is worse in Hispanic/Latino or Black ALL patients compared to those who are non-Hispanic White. Different molecular subtypes of ALL show heterogeneities in incidence rates and survival outcomes across age groups and race/ethnicity. Several ALL risk variants are associated with genetic ancestry, and demonstrate different risk allele frequencies and/or effect sizes across populations. Moreover, non-genetic factors including socioeconomic status, access to care, and environmental exposures all likely influence the disparities in ALL risk and survival. Further studies are needed to investigate the potential joint effects and interactions of genetic and environmental risk factors. Improving survival in Hispanic/Latino and Black patients with ALL requires advances in precision medicine approaches, improved access

show abstract

Childhood cancer incidence among specific Asian and Pacific Islander populations in the United States

Cited by 9 publications

References 40 publications

Racial and ethnic disparities in pediatric cancer incidence among children and young adults in the United States by single year of age

Racial and ethnic disparities in pediatric cancer incidence among children and young adults in the United States by single year of age

Persistently high incidence rates of childhood acute leukemias from 2010 to 2017 in Mexico City: A population study from the MIGICCL

Disparities in acute lymphoblastic leukemia risk and survival across the lifespan in the United States of America

Contact Info

Product

Resources

About