Childhood chronic myeloid leukemia with celiac disease

BCR-ABL1 Fusion Gene Positive Chronic Myeloid Leukemia - Chronic Phase in Childhood

“…The median age at diagnosis is in the 5th and 6th decades of life (WHO, 2008). CML occurring in children is a rare diagnosis, accounting for less than 10% of all CML and less than 2% of all pediatric leukemias (Hara et al, 2010, Singhal et al, 2010, Aperley, 2009, Radhakrishnan et al, 2009, Suttorp et al, 2009) {1,2,3,4,5}. Two distinct forms have been described, namely -the juvenile and adult type [4,5] .…”

“…In children below 10 years, it is even rarer. Only modem of information is available in the form of case reports [2,3] . Diagnosis of such cases can be made from peripheral blood smear examination, supported bykaryotypic study.…”

“…Diagnosis of such cases can be made from peripheral blood smear examination, supported bykaryotypic study. Though biologic behaviour and prognosis are identical to that of adult type, we are reporting this case because of its extremely uncommon incidence [1,2] Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that originates in a abnormal pluripotent bone marrow stem cell. The median age at diagnosis is in the 5th and 6th decades of life (WHO, 2008).…”