Childhood embryonal carcinoma of testis, report of two unusual cases, and the implication on clinical management

Chu, Jhih‐Wei; O’Connor, Dennis M.; deMello, Daphne E.; Razek, Aly; McElfresh, Arthur E.

doi:10.1002/mpo.2950040214

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…In patients with stage I disease, the addition of single agent chemotherapy was as effective as no chemotherapy. Whether chemotherapy is indicated or not should be investigated in a large scale randomized study [26,27].…”

Section: Ovarian Germ Cell Tumorsmentioning

confidence: 99%

Germ cell tumors in children: Gonadal and extragonadal

Wollner

Ghavimi

Wachtel

et al. 1991

Med. Pediatr. Oncol.

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Sixty-three pediatric patients with germ cell tumors are presented with details of symptoms, histological findings, staging, serological markers, treatment, and response to therapy. The primary sites were: ovarian 32, testicular 17, presacral 7, mediastinal 3, intraabdominal 2, vaginal 1, and right inguinal canal 1. These patients were treated with T2 (sequential use of dactinomycin, doxorubicin, vincristine, and cyclophosphamide, with or without radiation), T6 (combination chemotherapy with cyclophosphamide, bleomycin, dactinomycin, doxorubicin, methotrexate, vincristine), or VAB treatment protocols (velban, dactinomycin, bleomycin, cisplatin). The cure rate for stage I ovarian and testicular germ cell tumors was 100%; for stage III, all primary sites, 82% and for stage IV, all primary sites, 75%. Histology was prognostic in ovarian tumors of the immature malignant teratoma type; the neural type immature teratoma, grades II and III, had the worst prognosis. Initial debulking surgery in combination with chemotherapy and radiation plays an important role in germ cell tumors. Stages II, III, and IV germ cell tumors require aggressive treatment with surgery, radiation, and chemotherapy. For stage I patients, with primary ovarian malignant tumor, cure with surgery alone can be achieved in 50% of the cases and in testicular tumors in about 70% of the patients. For those with stage I and elevated serological markers, it is feasible to follow these markers and give no treatment until there is evidence of persistent elevation or a rise in titers after an initial fall. In those without elevated serological markers, one should take into consideration the size of the tumor and the histological type before taking the "wait and see" approach. These stage I tumors are highly curable when they first present but, if allowed to recur, chemotherapy may not offer the patient such a favorable response and cure rate.

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Section: Ovarian Germ Cell Tumorsmentioning

confidence: 99%

Germ cell tumors in children: Gonadal and extragonadal

Wollner

Ghavimi

Wachtel

et al. 1991

Med. Pediatr. Oncol.

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“…The effectiveness of irradiation in childhood yolk sac tumors has been judged differently by various authors. Some apply irradiation to the retroperi toneal lymph nodes as sole therapy [21], or as part of a treatment regimen [32,57], while others doubt its effec tiveness for these tumors altogether [58]. In all, 114 chil dren with yolk sac tumors have undergone irradiation.…”

Section: Radiotherapymentioning

confidence: 99%

Germinal Testicular Tumors in Childhood

Weißbach¹,

Altwein²,

Stiens³

1984

Eur Urol

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Successful chemotherapy for childhood metastatic embryonal cell carcinoma of the testicle: A preliminary report

Holbrook

Crist

Cain

et al. 1980

Med. Pediatr. Oncol.

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A child with widespread metastases successfully treated with chemotherapy alone is described. One course of combination chemotherapy using cis-platinum, vinblastine, and bleomycin produced disappearance of multiple pulmonary metastatic lesions. Four courses of therapy produced shrinkage and tumor sterilization of an abdominal mass. Twenty-six months after initiation of chemotherapy the patient is well, off of all therapy for fourteen months, and free of disease or drug related complication with normal creatinine clearance and alphafetoprotein determinations. The published adult experience demonstrates that this therapy is extremely effective for the treatment of metastatic embryonal cell carcinoma of the testis in young adults, and our case report extends this favorable experience into childhood. Toxicity is substantial, but justifiable considering the poor outlook associated with widespread metastatic disease. Collectively, the reviewed data suggest that further trials of this type of therapy are indicated in children.

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Childhood embryonal carcinoma of testis, report of two unusual cases, and the implication on clinical management

Cited by 4 publications

References 9 publications

Germ cell tumors in children: Gonadal and extragonadal

Germ cell tumors in children: Gonadal and extragonadal

Germinal Testicular Tumors in Childhood

Successful chemotherapy for childhood metastatic embryonal cell carcinoma of the testicle: A preliminary report

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