Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis

Bay, Bjørn; Lyngsø, Julie; Hohwü, Lena; Kesmodel, Ulrik Schiøler

doi:10.1111/1471-0528.15456

Cited by 33 publications

(28 citation statements)

References 35 publications

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“…There remains a paucity of studies examining patterns of childhood growth in children conceived with ICSI. In a recent systematic review and meta-analysis of studies of childhood growth in singletons (age range 1-28 years, median 5 years), children conceived with ICSI were found to have similar weight and height to those conceived spontaneously (17). In several of the included studies, comparable childhood weight was observed in the ICSI and spontaneous conception groups, despite ICSI children having lower birth weights, indicating a higher rate of postnatal growth in this group.…”

Section: Growth Adiposity and Cardiometabolic Healthmentioning

confidence: 98%

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Impact of male factor infertility on offspring health and development

Rumbold

Sevoyan

Oswald

et al. 2019

Fertility and Sterility

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Monitoring the safety of intracytoplasmic sperm injection (ICSI) has been impeded by uncertainties regarding the extent to which offspring health is influenced by paternal characteristics linked to male infertility or the processes that ICSI treatment entails. Few studies examining long-term health and developmental outcomes in children conceived with ICSI have considered the influence of paternal infertility adequately. In the available literature, large population-based studies suggest underlying male factors, and the severity of male factor infertility, increase the risk of mental retardation and autism in offspring, as does the ICSI procedure itself, but these findings have not been replicated consistently. Robust evidence of the influence of male factors on other health outcomes is lacking, with many studies limited by sample size. Nevertheless, emerging evidence suggests children conceived with ICSI have increased adiposity, particularly girls. Further, young men conceived with ICSI may have impaired spermatogenesis; the mechanisms underlying this remain unclear, with inconclusive evidence of inheritance of Y chromosome microdeletions. The current inconsistent and often sparse literature concerning the long-term health of children conceived with ICSI, and the specific influence of male infertility factors, underscore the need for concerted monitoring of children conceived with this technique across the lifespan. With the rapid expansion of use of ICSI for non-male factors, sufficiently large studies that compare outcomes between groups conceived with this technique for male factors versus non-male factors will provide critical evidence to elucidate the intergenerational impact of male infertility.

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Section: Growth Adiposity and Cardiometabolic Healthmentioning

confidence: 98%

“…Several reviews of the literature pertaining to long-term health and developmental outcomes of children conceived with ICSI have now been undertaken (14)(15)(16)(17). These reviews identify possible increased risks of certain neurodevelopmental disorders, as well as impaired cardiometabolic and reproductive health profiles among children conceived with ICSI.…”

mentioning

confidence: 99%

Impact of male factor infertility on offspring health and development

Rumbold

Sevoyan

Oswald

et al. 2019

Fertility and Sterility

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“…By contrast, a meta‐analysis of 11 studies 5 and two large cohort studies 6,7 found a reduced risk of SGA and FGR by about 45% and an increased risk of being large‐for‐gestational age (LGA) by 30–90%, in IVF/ICSI pregnancies conceived after FBT, as compared to after fresh embryo transfer. No long‐term weight and height differences were found above 5 years of age in a large meta‐analysis of 20 studies investigating childhood growth of singletons conceived after IVF/ICSI 8 . The basis for reduced fetal growth in IVF/ICSI pregnancies from fresh cycles and greater fetal growth following FBT remains to be determined; however, it is clear that fetal and placental development in these different settings need further investigation.…”

Section: Introductionmentioning

confidence: 97%

Uterine artery Doppler in singleton pregnancies conceived after in‐vitro fertilization or intracytoplasmic sperm injection with fresh vs frozen blastocyst transfer: longitudinal cohort study

Cavoretto

Farina

Gaeta

et al. 2020

Ultrasound in Obstet & Gyne

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What are the novel findings of this work? In-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) pregnancies conceived after frozen blastocyst transfer (FBT), as compared to fresh, have lower uterine artery pulsatility index (UtA-PI) at 7-37 weeks' gestation and a lower rate of small-for-gestational age (SGA). What are the clinical implications of this work? IVF/ICSI pregnancies conceived after FBT and those conceived after fresh blastocyst transfer show different prenatal behavior, probably due to inherent group differences. Pregnancies conceived after fresh blastocyst transfer require increased fetal surveillance, due to higher UtA-PI and risk of SGA. Placental perfusion and maternal cardiovascular function in IVF/ICSI pregnancy needs to be investigated further.

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“…Another recent meta-analysis indicated that children conceived by IVF and ICSI showed a lower weight during the first 4 years of age, with the difference disappearing afterwards (Bay et al 2019), indicating an enhanced growth velocity during early development. Rapid growth during early childhood can increase the risk of developing obesity and hypertension later in life (Mihrshahi et al 2011, Lei et al 2015.…”

Section: Assisted Reproductive Technologiesmentioning

confidence: 99%

Periconceptional environment and the developmental origins of disease

Velazquez

Fleming

Watkins

2019

Journal of Endocrinology

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The concept emerging from Professor David Barker’s seminal research on the developmental origins of later-life disease has progressed in many directions since it was first published. One critical question being when during gestation might environment alter the developmental programme with such enduring consequences. Here, we review the growing consensus from clinical and animal research that the period around conception, embracing gamete maturation and early embryogenesis might be the most vulnerable period. We focus on four types of environmental exposure shown to modify periconceptional reproduction and offspring development and health: maternal overnutrition and obesity; maternal undernutrition; paternal diet and health; and assisted reproductive technology. These conditions may act through diverse epigenetic, cellular and physiological mechanisms to alter gene expression and cellular signalling and function in the conceptus affecting offspring growth and metabolism leading to increased risk for cardiometabolic and neurological disease in later life.

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Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis

Abstract: Children born following IVF/ICSI do not have impaired long-term weight or height compared with spontaneously conceived children.

Cited by 33 publications

References 35 publications

Impact of male factor infertility on offspring health and development

Impact of male factor infertility on offspring health and development

Uterine artery Doppler in singleton pregnancies conceived after in‐vitro fertilization or intracytoplasmic sperm injection with fresh vs frozen blastocyst transfer: longitudinal cohort study

Periconceptional environment and the developmental origins of disease

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