Childhood Hodgkin Lymphoma in Iran; survival and outcome

Mehrvar, Azim; Tashvighi, Maryam; Nourian, Mahyar; Mehrvar, Narjes; Ghorbani, Raheb; Sadeghi, Yasaman; Alebouyeh, Mardavig; Faranoush, Mohammad

doi:10.1016/j.phoj.2020.06.008

Cited by 2 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rate of treatment failure is in keeping with studies in wellresourced settings 17 and lower than in a similar setting in Iran, 18 although the latter study did not have histological confirmation, and refractory disease was diagnosed based on end-of-treatment PET-CT.…”

Section: Discussionsupporting

confidence: 73%

Improved survival of children and adolescents with classical Hodgkin lymphoma treated on a harmonised protocol in South Africa

Geel,

van Zyl,

Plessis

et al. 2023

Pediatric Blood & Cancer

View full text Add to dashboard Cite

BackgroundHistoric South African 5‐year overall survival (OS) rates for Hodgkin lymphoma (HL) from 2000 to 2010 were 46% and 84% for human immunodeficiency virus (HIV)‐positive and HIV‐negative children, respectively. We investigated whether a harmonised treatment protocol using risk stratification and response‐adapted therapy could increase the OS of childhood and adolescent HL.MethodsSeventeen units prospectively enrolled patients less than 18 years, newly diagnosed with classical HL onto a risk‐stratified, response‐adapted treatment protocol from July 2016 to December 2022. Low‐ and intermediate‐risk patients received four and six courses of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD), respectively. High‐risk patients received two courses of ABVD, followed by four courses of cyclophosphamide, vincristine, prednisone, and dacarbazine (COPDac). Those with a slow early response and bulky disease received consolidation radiotherapy. HIV‐positive patients could receive granulocyte colony‐stimulating factor and less intensive therapy if stratified as high risk, at the treating clinician's discretion. Kaplan–Meier survival analysis was performed to determine 2‐year OS and Cox regression to elucidate prognostic factors.ResultsThe cohort comprised 132 patients (19 HIV‐positive, 113 HIV‐negative), median age of 9.7 years, with a median follow‐up of 2.2 years. Risk grouping comprised nine (7%) low risk, 36 (27%) intermediate risk and 87 (66%) high risk, with 71 (54%) rapid early responders and 45 (34%) slow early responders, and 16 (12%) undocumented. Two‐year OS was 100% for low‐risk, 93% for intermediate‐risk, and 91% for high‐risk patients. OS for HIV‐negative (93%) and HIV‐positive (89%) patients were similar (p = .53). Absolute lymphocyte count greater than 0.6 × 109 predicted survival (94% vs. 83%, p = .02).ConclusionIn the first South African harmonised HL treatment protocol, risk stratification correlated with prognosis. Two‐year OS of HIV‐positive and HIV‐negative patients improved since 2010, partially ascribed to standardised treatment and increased supportive care. This improved survival strengthens the harmonisation movement and gives hope that South Africa will achieve the WHO Global Initiative for Childhood Cancer goals.

show abstract

Section: Discussionsupporting

confidence: 73%

Improved survival of children and adolescents with classical Hodgkin lymphoma treated on a harmonised protocol in South Africa

Geel,

van Zyl,

Plessis

et al. 2023

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…The 1-year and 5-year lymphoma survival rate was over 95.5%, and there was a slight difference between the levels of age groups and gender. A previous study on childhood HL in Iran had shown that overall survival rates of 2 and 5 years were 98.9% and 93.8 in patients younger than 19 years of age 31. In high-income countries such as the USA and Canada, survival rate was reported at 97.5%–100% for HL, 97% for NHL and 85%–87.4% for Burkitt lymphoma.…”

Section: Discussionmentioning

confidence: 97%

“…A previous study on childhood HL in Iran had shown that overall survival rates of 2 and 5 years were 98.9% and 93.8 in patients younger than 19 years of age. 31 In high-income countries such as the USA and Canada, survival rate was reported at 97.5%–100% for HL, 97% for NHL and 85%–87.4% for Burkitt lymphoma. Additionally, boys had better survival than girls.…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal variations in childhood lymphoma cancer incidence and its survival rate in Iran, 2005–2015: a cross-sectional study

Ziyaee

Akbari

Looha

et al. 2023

bmjpo

View full text Add to dashboard Cite

BackgroundChildhood lymphoma is the second leading cause of cancer in children under 15 years of age in Iran. The aim of this study was to investigate the spatial and time variations in lymphoma incidence as well as the children’s survival time in Iran.MethodThis cross-sectional study was conducted using lymphoma cases (children under 14 years of age) from 2005 to 2015, and the data were obtained from the National Cancer Registry Center. The frequency, age-standardised incidence rate (ASIR), spatial clustering in national level and the survival rate (1 year and 5 years) using Kaplan-Meier method were evaluated. We used Spatial and Temporal Scan statistics software in order to detect statistically significant clusters in spatial analysis.ResultsA total number of 746 girls and 1610 boys were diagnosed with lymphoma during a 10-year period. ASIRs (per 100 000 people) for girls ranged from 0 in Ilam to 3.47 in Yasuj, and it ranged from 0.19 in Ilam to 5.91 in Yazd for boys from 2005 to 2015. Spatial analysis result showed a large statistically significant cluster (the most likely cluster) for both boys (relative risk (RR)=2.37) and girls (RR=2.49) located in the northwest of Iran. Fortunately, survival rate for both boys and girls was over 95.5%.ConclusionLymphoma incidence rates had heterogeneous geographical distribution, and some significant clusters were identified which strengthens the role of possible aetiological factors, and further studies are needed to clarify this ambiguity. Fortunately, the survival rate of this cancer in Iran was good and it was similar to the high-income countries.

show abstract

Childhood Hodgkin Lymphoma in Iran; survival and outcome

Cited by 2 publications

References 27 publications

Improved survival of children and adolescents with classical Hodgkin lymphoma treated on a harmonised protocol in South Africa

Improved survival of children and adolescents with classical Hodgkin lymphoma treated on a harmonised protocol in South Africa

Spatiotemporal variations in childhood lymphoma cancer incidence and its survival rate in Iran, 2005–2015: a cross-sectional study

Contact Info

Product

Resources

About