“…Many types of ACEs have been described to be associated with the beginning and continued consumption of alcohol, tobacco and illicit drugs during adolescence 2,4,11,12,13,14,15,16,17,20,21 . Some evidence for higher risk of substance use has been found for parental divorce, neglect, domestic violence, physical abuse, sexual abuse, a poor relationship or lack of communication with parents, family background of drug addiction, and unstructured families 2,4,11,12,13,14,15,16,17,20,21 . The association between ACEs and substance use can differ according to gender 13,22 , and females may have a higher risk than males 13 .…”