Childhood maltreatment is associated with gray matter volume abnormalities in patients with first-episode depression

Yang, Shuran; Cheng, Yuqi; Mo, Yin; Bai, Yan; Shen, Zonglin; Liu, Fang; Li, Na; Jiang, Linling; Chen, Wei; Lü, Yi; Sun, Xiaotao; Xu, Xiufeng

doi:10.1016/j.pscychresns.2017.07.005

Cited by 39 publications

(22 citation statements)

References 65 publications

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“…These findings align with previous research associating maltreatment with poorer global cognition, memory, working memory, and processing speed in adults with MDD and other psychiatric disorders (Grassi-Oliveira et al ., 2008; Bucker et al ., 2013; Miller et al ., 2015; Masson et al ., 2016; Dannehl et al ., 2017; Saleh et al ., 2017), as well as previous work associating maltreatment with abnormal brain structure and functioning in frontal, limbic, and medial temporal regions underlying cognition (Dannlowski et al ., 2012; Lim et al ., 2014; Philip et al ., 2014). Such structural and functional changes intersect with those commonly reported in MDD (Sacher et al ., 2012); indeed, neuroimaging studies have found that maltreatment is independently associated with fronto-limbic abnormalities previously thought to be specific to depression (Opel et al ., 2014; Yang et al ., 2017). These studies provide a neurobiological context for our findings that cognitive deficits are more severe in DM+ participants.…”

Section: Discussionmentioning

confidence: 99%

Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report

et al. 2019

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BackgroundPatients with major depressive disorder (MDD) display cognitive deficits in acutely depressed and remitted states. Childhood maltreatment is associated with cognitive dysfunction in adults, but its impact on cognition and treatment related cognitive outcomes in adult MDD has received little consideration. We investigate whether, compared to patients without maltreatment and healthy participants, adult MDD patients with childhood maltreatment display greater cognitive deficits in acute depression, lower treatment-associated cognitive improvements, and lower cognitive performance in remission.MethodsHealthy and acutely depressed MDD participants were enrolled in a multi-center MDD predictive marker discovery trial. MDD participants received 16 weeks of standardized antidepressant treatment. Maltreatment and cognition were assessed with the Childhood Experience of Care and Abuse interview and the CNS Vital Signs battery, respectively. Cognitive scores and change from baseline to week 16 were compared amongst MDD participants with (DM+, n = 93) and without maltreatment (DM−, n = 90), and healthy participants with (HM+, n = 22) and without maltreatment (HM−, n = 80). Separate analyses in MDD participants who remitted were conducted.ResultsDM+ had lower baseline global cognition, processing speed, and memory v. HM−, with no significant baseline differences amongst DM−, HM+, and HM− groups. There were no significant between-group differences in cognitive change over 16 weeks. Post-treatment remitted DM+, but not remitted DM−, scored significantly lower than HM− in working memory and processing speed.ConclusionsChildhood maltreatment was associated with cognitive deficits in depressed and remitted adults with MDD. Maltreatment may be a risk factor for more severe and persistent cognitive deficits in adult MDD.

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Section: Discussionmentioning

confidence: 99%

Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report

et al. 2019

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“…Four studies examined mPFC GMV differences between resilient and vulnerable adults (Table 1), and did not find significant differences in mPFC GMV of resilient vs. vulnerable adults (31, [39][40][41]. Eight studies compared mPFC GMV in resilient adults vs. healthy adults (Table 1), and reported similar mPFC (39,42,43) or smaller mPFC GMV (22,26,31,36,40).…”

Section: Medial Prefrontal Cortex (Mpfc)mentioning

confidence: 99%

The Resilient Emotional Brain: A Scoping Review of the Medial Prefrontal Cortex and Limbic Structure and Function in Resilient Adults With a History of Childhood Maltreatment

Moreno-López

Ioannidis

Askelund

et al. 2020

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Childhood Maltreatment (CM) is one of the strongest predictors of adult mental illness, though not all adults with CM develop psychopathology. Here, we describe the structure and function of emotional brain regions that may contribute to resilient functioning after CM. We review studies that report medial prefrontal cortex (mPFC), amygdala and hippocampus ('limbic regions') structure, function, and/or connections, in resilient (i.e., adults reporting CM without psychopathology) vs. vulnerable (i.e., adults reporting CM with psychopathology), or healthy adults (adults without CM with no psychopatology). We find that resilient adults have larger hippocampal grey and white matter volume, and increased connectivity between the central executive network and limbic regions. In addition, resilient adults have improved ability to regulate emotions through mPFC-limbic downregulation, lower hippocampal activation to emotional faces, and increased amygdala habituation to stress. We highlight the need for longitudinal designs that examine resilient functioning across domains and consider gender, type, timing, nature of CM assessments and further stressors, in order to further improve our understanding of the role of the emotional brain in resilient functioning after CM.

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“…[11][12][13][14][15][16] A significant MDD-by-CM interactive effect was found in the prefrontal cortex in a study that recruited relatively large numbers of MDD patients and controls. 17 Together, these findings demonstrate that CM and MDD exert interactive effects on GM volume. Furthermore, the results of structural neuroimaging studies of MDD treatment often suggest that GM volumes are altered after treatment in certain regions [18][19][20][21] including the temporal lobe.…”

Section: Introductionmentioning

confidence: 76%

“…Moreover, neuroimaging studies focused on CM have revealed CM‐related changes in GM volume in the hippocampus, medial prefrontal cortex and orbitofrontal cortex in both healthy subjects and current MDD patients . A significant MDD‐by‐CM interactive effect was found in the prefrontal cortex in a study that recruited relatively large numbers of MDD patients and controls . Together, these findings demonstrate that CM and MDD exert interactive effects on GM volume.…”

Section: Introductionmentioning

confidence: 80%

A shared effect of paroxetine treatment on gray matter volume in depressive patients with and without childhood maltreatment: A voxel‐based morphometry study

Guo

Sun

et al. 2018

CNS Neurosci Ther

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Summary Aims This study assessed whether antidepressant drug treatment has a common effect on gray matter (GM) volume in MDD patients with and without childhood maltreatment (CM). Methods T1‐weighted structural magnetic resonance imaging data were collected from 168 participants, including 51 MDD patients with CM, 31 MDD patients without CM, 48 normal controls with CM, and 38 normal controls without CM. MDD patients received 6 months of treatment with paroxetine, and 24 patients with CM, and 16 patients without CM received a second MRI scan. A whole‐brain voxel‐based morphometry approach was used to estimate GM volume in each participant at two time points. Two‐way analysis of variance (ANOVA) was used to determine the effects of MDD and CM on GM volume at baseline. Repeated measures two‐way ANOVA was used to determine the treatment‐by‐CM interactive effect and main effect of treatment during paroxetine treatment. We further investigated the relationship between GM volume and clinical variables. Results At baseline, significant MDD‐by‐CM interactive effects on GM volume were mainly observed in the left parahippocampal gyrus, left entorhinal cortex, and left cuneus. GM volume was significantly lower mainly in the right middle temporal gyrus in patients with MDD than in normal controls. We did not find any significant treatment‐by‐CM interactive effects. However, a treatment‐related increase in GM was found in the right middle temporal gyrus in both MDD groups. Conclusions These results suggest that paroxetine treatment operates via a shared neurobiological mechanism in MDD patients with and without CM.

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Childhood maltreatment is associated with gray matter volume abnormalities in patients with first-episode depression

Cited by 39 publications

References 65 publications

Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report

Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report

The Resilient Emotional Brain: A Scoping Review of the Medial Prefrontal Cortex and Limbic Structure and Function in Resilient Adults With a History of Childhood Maltreatment

A shared effect of paroxetine treatment on gray matter volume in depressive patients with and without childhood maltreatment: A voxel‐based morphometry study

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