Childhood trauma and adult interpersonal relationship problems in patients with depression and anxiety disorders

Huh, Hyu Jung; Kim, Sun‐Young; Yu, Jeong Jin; Chae, Jeong‐Ho

doi:10.1186/s12991-014-0026-y

Cited by 91 publications

(106 citation statements)

References 62 publications

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“…59 When integrating these findings with existing research, one potential hypothesis is that earlier traumatic experiences initiate childhood-adolescent STB, 60 but also heightened levels of affective-behavioral dysregulation, 61 and interpersonal stress sensitivity. 62 These traits, in turn, may be predictive for persistent STB into young adulthood, relatively independent from the earlier trauma that initiated them. If confirmed, we may have identified a group at risk for developing borderline personality disorder, given the strong association of this disorder with persistent STB, 63 as well as symptoms of mood instability, 64 interpersonal stressful experiences, 65 and physical or sexual trauma.…”

Section: Discussionmentioning

confidence: 99%

A Risk Algorithm for the Persistence of Suicidal Thoughts and Behaviors During College

Kiekens¹,

Auerbach²,

Cuijpers³

et al. 2017

J. Clin. Psychiatry

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OBJECTIVE The primary aims are to: (a) identify patterns of suicidal thoughts and behaviors (STB) during college among students with lifetime pre-matriculation STB and (b) develop a risk-screening algorithm for persistence of pre-matriculation STB during college. METHODS Data come from the Leuven College Surveys, a series of prospective cohort studies of all incoming KU Leuven University freshmen. In the academic year 2012 and 2013, 4,889 incoming freshmen (73.2% response rate) provided baseline data on socio-demographic variables, childhood-adolescent traumatic experiences, 12-month stressful experiences, 12-month mental disorders, 12-month STB, and severity markers of pre-matriculation STB. A total of 2,566 students (69.3% conditional response rate) participated in 12- and 24-month follow-up surveys during the first two college years. RESULTS Thirteen percent (weighted n=535) of incoming freshmen reported lifetime pre-matriculation STB. Of those, 28.0% reported 12-month STB in one follow-up assessment and another 27.7% in both follow-up assessments. High persistence of STB (i.e., 12-month STB in two follow-up assessments) was most strongly associated with severity markers of pre-matriculation STB, with odds ratios in the 2.4–10.3 range and population attributable risk proportions between 9.2% and 50.8%. When aiming for less than 50% of false positive cases (PPV=54.4%), a multivariate predictive risk algorithm (cross-validated AUC=0.79) situated 59.9% of highly persistent cases among the 30% respondents with highest baseline predicted risk. CONCLUSION An individualized web-based screening approach is a promising strategy to identify students at the onset of university who may be at high risk for STB persistence during their academic career.

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Section: Discussionmentioning

confidence: 99%

A Risk Algorithm for the Persistence of Suicidal Thoughts and Behaviors During College

Kiekens¹,

Auerbach²,

Cuijpers³

et al. 2017

J. Clin. Psychiatry

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show abstract

“…Thirdly, although subjects were monitored for drowsiness during rsfMRI, we did not correlate levels of awareness with entropy values. Fourthly, given that the subjects did not rate their level of anxiety for the anticipation of the impeding shock, it is possible that the correlations seen here are more related to individual anxiety levels compared to aversive responding per se, especially as anxiety has been previously tied to NCEs [Huh et al, ]. Finally, subjects were recruited from the local student population and so, given the general class and educational structure of such a group, may not be representative of the population as a whole.…”

Section: Limitations and Conclusionmentioning

confidence: 99%

Negative childhood experiences alter a prefrontal‐insular‐motor cortical network in healthy adults: A preliminary multimodal rsfMRI‐fMRI‐MRS‐dMRI study

Duncan

Hayes

Wiebking

et al. 2015

Human Brain Mapping

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Research in humans and animals has shown that negative childhood experiences (NCE) can have long-term effects on the structure and function of the brain. Alterations have been noted in grey and white matter, in the brain’s resting state, on the glutamatergic system, and on neural and behavioural responses to aversive stimuli. These effects can be linked to psychiatric disorder such as depression and anxiety disorders that are influenced by excessive exposure to early life stressors. The aim of the current study was to investigate the effect of NCEs on these systems. Resting state functional MRI (rsfMRI), aversion task fMRI, glutamate magnetic resonance spectroscopy (MRS), and diffusion magnetic resonance imaging (dMRI) were combined with the Childhood Trauma Questionnaire (CTQ) in healthy subjects to examine the impact of NCEs on the brain. Low CTQ scores, a measure of NCEs, were related to higher resting state glutamate levels and higher resting state entropy in the medial prefrontal cortex (mPFC). CTQ scores, mPFC glutamate and entropy, correlated with neural BOLD responses to the anticipation of aversive stimuli in regions throughout the aversion-related network, with strong correlations between all measures in the motor cortex and left insula. Structural connectivity strength, measured using mean fractional anisotropy, between the mPFC and left insula correlated to aversion-related signal changes in the motor cortex. These findings highlight the impact of NCEs on multiple inter-related brain systems. In particular, they highlight the role of a prefrontal-insular-motor cortical network in the processing and responsivity to aversive stimuli and its potential adaptability by NCEs.

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“…Studies examining child abuse and neglect in clinical and non-clinical samples have not tended to report physical neglect as a potent predictor of relationship or personality functioning (e.g., Huh, Kim, Yu, & Chae, 2014;Sudbrack, Manfro, Kuhn, de Carvalho, & Lara, 2015). Yet for the current participants, all with psychiatric difficulties and a history of child maltreatment, physical neglect was curiously associated with lower relationship anxiety.…”

Section: Discussionmentioning

confidence: 61%

Child abuse and neglect in complex dissociative disorder, abuse-related chronic PTSD, and mixed psychiatric samples

Dorahy

Middleton

Seager

et al. 2015

Journal of Trauma & Dissociation

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Only a select number of studies have examined different forms of child maltreatment in complex dissociative disorders (DDs) in comparison to other groups. Few of these have used child abuse-related chronic posttraumatic stress disorder (C-PTSD) and mixed psychiatric (MP) patients with maltreatment as comparison groups. This study examined child sexual, physical, and emotional abuse as well as physical and emotional neglect in DD (n = 39), C-PTSD (n = 13), and MP (n = 21) samples, all with abuse and neglect histories. The predictive capacity of these different forms of maltreatment across the 3 groups was assessed for pathological dissociation, shame, guilt, relationship esteem, relationship anxiety, relationship depression, and fear of relationships. All forms of maltreatment differentiated the DD from the MP group, and sexual abuse differentiated the DD sample from the C-PTSD group. Childhood sexual abuse was the only predictor of pathological dissociation. Emotional abuse predicted shame, guilt, relationship anxiety, and fear of relationships. Emotional neglect predicted relationship anxiety and relationship depression. Physical neglect was associated with less relationship anxiety. Different forms of abuse and neglect are associated with different symptom clusters in psychiatric patients with maltreatment histories.

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Childhood trauma and adult interpersonal relationship problems in patients with depression and anxiety disorders

Cited by 91 publications

References 62 publications

A Risk Algorithm for the Persistence of Suicidal Thoughts and Behaviors During College

A Risk Algorithm for the Persistence of Suicidal Thoughts and Behaviors During College

Negative childhood experiences alter a prefrontal‐insular‐motor cortical network in healthy adults: A preliminary multimodal rsfMRI‐fMRI‐MRS‐dMRI study

Child abuse and neglect in complex dissociative disorder, abuse-related chronic PTSD, and mixed psychiatric samples

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