Childhood trauma and increased peripheral cytokines in young adults with major depressive: Population-based study

Moreira, Fernanda Pedrotti; Wiener, Carolina David; Jansen, Karen; Portela, Luis Valmor; Lara, Diogo R.; Souza, Luciano Dias de Mattos; Silva, Ricardo Azevedo da; Oses, Jean Pierre

doi:10.1016/j.jneuroim.2018.02.018

Cited by 33 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The articles presented in this review evaluated sexual abuse as an independent variable alone or a subtype of childhood maltreatment (CM), in this case the authors investigated other types of abuse besides CSA, making correlations between the inflammatory markers and each type of abuse, including CSA. Only two studies evaluated exclusively CSA ( 37 , 48 ), other two data investigated physical and sexual abuse ( 38 , 51 ), the remain 13 studies evaluated all subtypes of maltreatment and the correlation of each subtype, and CM global scores, to immune system alterations ( 39 – 47 , 49 , 50 , 52 , 53 ).…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies ( 39 , 40 , 42 , 44 – 47 , 52 , 53 ) used the Childhood Trauma Questionnaire (CTQ), a self-applicable instrument used for assessing physical, emotional, sexual abuses as well as physical and emotional negligence ( 54 ). The items are added up so that the five different subtypes of abuse score differently.…”

Section: Resultsmentioning

confidence: 99%

“…Zeugmann et al retrospectively evaluated 25 depressed patients with childhood maltreatment history and found no correlation between CSA and IL-6 levels ( 53 ). Pedrotti Moreira et al found no correlations between CSA and IL-6, although they found an association between physical and emotional abuse and higher IL-6 levels ( 47 ).…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies analyzed the levels of TNF-α, a cytokine produced by macrophages and natural killer cell, which presented rather conflicting results ( 37 , 40 , 42 – 44 , 47 , 53 ). Grosse et al demonstrated increased TNF-α levels in patients with MDD who reported CSA, as compared to controls (β = 0.570, p = 0.001) ( 51 ).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Childhood Sexual Abuse and Indicators of Immune Activity: A Systematic Review

et al. 2018

View full text Add to dashboard Cite

Background: Childhood sexual abuse (CSA) is a prevalent subtype of early life stress associated with changes in immunological and neuroendocrine systems leading to inflammatory responses of the organism and increasing several inflammatory and immune markers. We aimed to conduct a systematic review concerning the association between CSA and indicators of immune activity.Methods: We conducted a search for articles in PubMed, Scopus, PsycINFO, and Web of Science, using the key words: (“Child sexual abuse” OR “childhood maltreatment” OR “sexual violence” OR “posttraumatic stress disorder” OR “rape”) AND (“cytokines” OR “inflammatory markers” OR “interleukin” OR “tumor necrosis factor” OR “C-reactive protein”). PRISMA guidelines were used in order to improve the quality of this research, and MeSH terms were used in PubMed.Results: A total of 3,583 studies were found and, after application of the exclusion criteria, 17 studies were included in this review. Most studies reported an increase of inflammatory activity associated with the presence of early abuse. IL-6, TNF- α, and C-reactive protein were the most frequently analyzed markers and some studies showed higher levels in individuals that suffered CSA compared with controls, although the results were heterogeneous, as was the assessment of CSA, repeated trauma, and time of occurrence. It was not possible to perform a meta-analysis because the results were diversified.Conclusion: CSA is associated with changes in inflammatory markers levels. Improving the assessment of subtypes of trauma is important to further understand the complex correlations of CSA and its biological consequences such as psychiatric and physical illness in later life.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Childhood Sexual Abuse and Indicators of Immune Activity: A Systematic Review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…These cytokines are produced by a variety of cell types including immune cells, muscular cells, glial cells and neurons; they mediate signaling between immune cells, and are mainly secreted from monocytes, macrophages or lymphocytes [20]. Moreover, cytokines play a central role in the control and modulation of inflammatory responses, and modulate the neurotrophins, with a constant balance between proinflammatory and anti-inflammatory cytokines [21].…”

Section: Introductionmentioning

confidence: 99%

Bipolar and Schizophrenia Disorders Diagnosis Using Artificial Neural Network

Fonseca¹,

Andrades²,

Bach³

et al. 2018

Self Cite

View full text Add to dashboard Cite

Motivation: Bipolar disorder (BD) and schizophrenia (SZ) has a difficult diagnosis, so the main objective of this article is to propose the use of Artificial Neural Networks (ANNs) to classify (diagnose) groups of patients with BD or SZ from a control group using sociodemographic and biochemical variables. Methods: Artificial neural networks are used as classifying tool. The data from this study were obtained from the array collection from Stanley Neuropathology Consortium databank. Inflammatory markers and characteristics of the sampled population were the inputs variables. Results: Our findings suggest that an artificial neural network could be trained with more than 90% accuracy, aiming the classification and diagnosis of bipolar, schizophrenia and control healthy group. Conclusion: Trained ANNs could be used to improve diagnosis in Schizophrenia and Bipolar disorders. upon the activation function [1]. The ANN inputs are multiplied by different weights to generate a predictive response. So, these responses in ANN are widely used for several applications such as classification and pattern recognition [2].This tool is effective modeling non-linear relationships that may be a promising candidate for differentiation for several biological processes [3]. ANN are used in medical field to analysis of sleep disorders, cytopathology and histopathology

show abstract

Efficacy of Adjunctive Infliximab vs Placebo in the Treatment of Adults With Bipolar I/II Depression

et al. 2019

View full text Add to dashboard Cite

IMPORTANCE To our knowledge, no study has previously evaluated whether individuals with bipolar depression enriched a priori on the basis of biochemical and/or phenotypic immuno-inflammatory activation would differentially respond to an anti-inflammatory agent for the treatment of depressive symptoms. OBJECTIVE To assess the antidepressant efficacy of adjunctive infliximab, a monoclonal antibody targeting tumor necrosis factor, in adults with bipolar I and bipolar II depression and inflammatory conditions. DESIGN, SETTING, AND PARTICIPANTS This 12-week, randomized, double-blind, placebo-controlled, parallel-group trial of 60 participants was conducted at 2 outpatient tertiary care sites in Canada and the United States. Eligible adults (aged 18-65 years) met DSM-5-defined criteria for bipolar I or bipolar II depression and exhibited pretreatment biochemical and/or phenotypic evidence of inflammatory activation. Participants were enrolled between October 1, 2015, and April 30, 2018. Data analysis was performed from May 1 through July 31, 2018, using modified intent-to-treat analysis. INTERVENTIONS Patients were randomized to receive 3 intravenous infusions of infliximab therapy or placebo at baseline and at weeks 2 and 6 of the 12-week study. MAIN OUTCOMES AND MEASURES The primary efficacy outcome was baseline-to-end point (ie, week-12) change in Montgomery-Asberg Depression Rating Scale (MADRS) total score. History of childhood maltreatment, as assessed by the Childhood Trauma Questionnaire, was used for exploratory analyses as 1 of several secondary outcomes. RESULTS A total of 60 participants were randomized to infliximab (n = 29 [48%]; mean [SD] age, 45.0 [11.7] years; 20 of 28 female [71%]) or to placebo (n = 31 [52%]; mean [SD] age, 46.8 [10.2] years; 26 of 30 female [87%]) across study sites. Overall baseline-to-end point change in MADRS total score was observed across treatment × time interaction (χ 2 = 10.33; P = .04); reduction in symptom severity was not significant at week 12 (relative risk, 1.09; 95% CI, 0.80-1.50; df= 1; P = .60). As part of a secondary analysis, a significant treatment × time × childhood maltreatment interaction was observed in which infliximab-treated individuals with childhood history of physical abuse exhibited greater reductions in MADRS total score (χ 2 = 12.20; P = .02) and higher response rates (Ն50% reduction in MADRS total score) (χ 2 = 4.05; P = .04). CONCLUSIONS AND RELEVANCE Infliximab did not significantly reduce depressive symptoms compared with placebo in adults with bipolar depression. Results from secondary analyses identified a subpopulation (ie, those reporting physical and/or sexual abuse) that exhibited a significant reduction in depressive symptoms with infliximab treatment compared with placebo.

show abstract

Childhood trauma and increased peripheral cytokines in young adults with major depressive: Population-based study

Abstract: Childhood maltreatment may result higher inflammation dysregulation in individuals with depression than individuals that no has childhood maltreatment.

Cited by 33 publications

References 31 publications

Childhood Sexual Abuse and Indicators of Immune Activity: A Systematic Review

Childhood Sexual Abuse and Indicators of Immune Activity: A Systematic Review

Bipolar and Schizophrenia Disorders Diagnosis Using Artificial Neural Network

Efficacy of Adjunctive Infliximab vs Placebo in the Treatment of Adults With Bipolar I/II Depression

Contact Info

Product

Resources

About