This study aims to determine the activity of exercise on reducing cardiovascular disease. This study used an experimental method with a one group pretest-postest research design). The population in this study was 15 adolescents in Makassar. The sample in this study was 15 adolescents in Makassar, sampling technique in total sampling. Data analysis techniques use the help of SPSS 23 software to test normality, homogeneity and t (influence) tests. From the results of the study found that sports activities have a significant influence on reducing cardiovascular disease with p value results of 0.000 < 0.05