Childhood tuberculosis: a concern of the modern world

Hamzaoui, A.; Yaalaoui, S.; Cherif, Fatma; Saidi, Leila Slim; Berraies, A.

doi:10.1183/09059180.00005314

Cited by 35 publications

(44 citation statements)

References 126 publications

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“…Childhood tuberculosis is often neglected as children are considered not to play a significant role in tuberculosis transmission . Due to the paucibacillary nature of the disease and difficulties with diagnosis confirmation, TB in pediatric population remains underdiagnosed and undertreated . On the other hand, childhood tuberculosis is an important marker of recent TB transmission in a community and reflects the level of tuberculosis control …”

Section: Introductionmentioning

confidence: 99%

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Is secretion of IFN‐gamma in response to Mycobacterium tuberculosis antigens in youngest children sufficient to play a role in TB diagnostics?

Bielecka

Komorowska-Piotrowska

Krenke

et al. 2017

Pediatric Pulmonology

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Section: Introductionmentioning

confidence: 99%

“…It is essential to correctly diagnose Mycobacterium tuberculosis infection (TB infection) in the youngest children, as they are more prone to develop active tuberculosis (ATB) . Treatment of latent tuberculosis infection (LTBI) is the main method of preventing disease development, which reduces the risk of progression by up to 90% .…”

Section: Introductionmentioning

confidence: 99%

Is secretion of IFN‐gamma in response to Mycobacterium tuberculosis antigens in youngest children sufficient to play a role in TB diagnostics?

Bielecka

Komorowska-Piotrowska

Krenke

et al. 2017

Pediatric Pulmonology

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“…In addition, it is well documented that TB research, prevention, and control worldwide have predominantly focused on adults, neglecting children 0 -14 years old [2] [3] [4] [5] [6]. However, children can no longer be ignored in TB research, prevention and control, as they accounted for 10% of the total global burden in 2016 [1], 15% in South Africa [7], 25% in Afghanistan [8], 3.4% in India [9], 7.9% in Peru [10], 13.7% in Nigeria…”

Section: Introductionmentioning

confidence: 99%

“…Once infected with mycobacterium tuberculosis, children tend to progress more quickly with the disease than adults [16]. The presence of CTB in a community reflects recent and current transmission of the infection in that community, and the burden of the disease provides a clue to the level of TB prevention and control efforts being achieved in that particular setting [4]. Ad- ditionally, the presence of infected children in a particular community is an indication of having a reservoir of the bacteria as well as the possibility of having future cases of infections if preventive measures are not taken [5].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Caregiver’s Quality of Life and Childhood Tuberculosis in Bauchi State, Northeastern Nigeria

Adamu¹,

Osoba²,

White³

et al. 2018

OALib

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Background: In Nigeria, childhood tuberculosis (TB), a debilitating and deadly disease, is highly prevalent and case reporting is poor due to weak health systems. Globally, children account for at least 10 percent of the TB burden, yet they remain neglected in TB prevention and control efforts. Research studies integrating family and community-centered strategies have been recommended by stakeholders to address the paucity of current local prevention and management strategies for childhood TB. Study Design: Observational study. Methods: This quantitative cross-sectional study explored the relationship between caregivers' quality of life (QOL) and the reporting of TB in their children aged 0 -14 years. Using the abbreviated version of World Health Organization's (WHO) QOL tool, the WHOQOL-BREF, data were collected individually in a face-to-face setting from caregivers (n = 47) whose children had been diagnosed with TB in Bauchi State, Northeastern Nigeria, over a 5-year period. Data were collected in the same manner from another set of caregivers of children without TB (n = 47) within the same period and setting. Results: Logistic regression indicated a statistically significant relationship (p < 0.001) between the caregivers' QOL and the reporting of childhood TB. Conclusion: This finding underscores the need to identify the factors that positively impact the QOL of caregivers of childhood TB cases. It also reflects the importance of integrating QOL interventions as part of TB control programs seeking to improve childhood TB reporting. This can mitigate the disease burden in vulnerable age-groups living in resource limited settings, thereby contributing to positive social change in the society.

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“…5 In order to accomplish this goal, an effective TB vaccine is urgently needed to prevent TB transmission in children. 6 At present, Mycobacterium bovis bacillus Calmette-Guerin (BCG) is the only licensed tuberculosis vaccine, which has been recommended by WHO for neonatal inoculation in the countries with a high TB prevalence. 7 BCG vaccination can protect the children from severe types of TB such as TB meningitis and miliary TB, while its efficacy against pediatric pulmonary TB has ranged from no protection to very high protection (0-80%).…”

Section: Introductionmentioning

confidence: 99%

Current status of new tuberculosis vaccine in children

Pang

Zhao

Cohen³

et al. 2016

Human Vaccines & Immunotherapeutics

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Pediatric tuberculosis contributes significantly to the burden of TB disease worldwide. In order to achieve the goal of eliminating TB by 2050, an effective TB vaccine is urgently needed to prevent TB transmission in children. BCG vaccination can protect children from the severe types of TB such as TB meningitis and miliary TB, while its efficacy against pediatric pulmonary TB ranged from no protection to very high protection. In recent decades, multiple new vaccine candidates have been developed, and shown encouraging safety and immunogenicity in the preclinical experiments. However, the limited data on protective efficacy in infants evaluated by clinical trials has been disappointing, an example being MVA85A. To date, no vaccine has been shown to be clinically safer and more effective than the presently licensed BCG vaccine. Hence, before a new vaccine is developed with more promising efficacy, we must reconsider how to better use the current BCG vaccine to maximize its effectiveness in children.

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Childhood tuberculosis: a concern of the modern world

Cited by 35 publications

References 126 publications

Is secretion of IFN‐gamma in response to Mycobacterium tuberculosis antigens in youngest children sufficient to play a role in TB diagnostics?

Is secretion of IFN‐gamma in response to Mycobacterium tuberculosis antigens in youngest children sufficient to play a role in TB diagnostics?

Relationship between Caregiver’s Quality of Life and Childhood Tuberculosis in Bauchi State, Northeastern Nigeria

Current status of new tuberculosis vaccine in children

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