Children and young people remain at low risk of COVID-19 mortality

Bhopal, Sunil; Bagaria, Jayshree; Olabi, Bayanne; Bhopal, Raj

doi:10.1016/s2352-4642(21)00066-3

Cited by 262 publications

(250 citation statements)

References 6 publications

(6 reference statements)

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“…Since March 2020, most governments around the world have closed schools and other educational institutions in an attempt to contain the diffusion of the COVID-19 pandemic, with an estimated dramatic impact on the education of over 850 million children and youths [1][2][3][4]. On the other hand, epidemiological data show that people aged 1-18 years tend to develop asymptomatic/paucisymptomatic disease, and, overall, present a significantly more favorable outcome than adults [5][6][7]. Furthermore, younger children seem to be less susceptible to infection and transmitting the disease compared to older children, adolescents, and adults [3,5].…”

Section: Introductionmentioning

confidence: 99%

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Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy

et al. 2021

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In the near future, COVID-19 vaccine efficacy trials in larger cohorts may offer the possibility to implement child and adolescent vaccination. The opening of the vaccination for these strata may play a key role in order to limit virus circulation, infection spreading towards the most vulnerable subjects, and plan safe school reopening. Vaccine hesitancy (VH) could limit the ability to reach the coverage threshold required to ensure herd immunity. The aim of this study was to investigate the prevalence and determinants of VH among parents/guardians toward a potentially available COVID-19 vaccination for children and adolescents. An online survey was performed in parents/guardians of children aged <18 years old, living in Bologna. Overall, 5054 questionnaires were collected. A vast majority (60.4%) of the parents/guardians were inclined to vaccinate, while 29.6% were still considering the opportunity, and 9.9% were hesitant. Highest vaccine hesitancy rates were detected in female parents/guardians of children aged 6–10 years, ≤29 years old, with low educational level, relying on information found in the web/social media, and disliking mandatory vaccination policies. Although preliminary, these data could help in designing target strategies to implement adherence to a vaccination campaign, with special regard to web-based information.

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, younger children seem to be less susceptible to infection and transmitting the disease compared to older children, adolescents, and adults [3,5]. However, with the emergence of new variants, the risk of disease transmission and outcomes in children deserve close surveillance [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy

et al. 2021

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“…Covid-19 severity in children under the age of 12 is similar to that of influenza,7 and as health resources are stretched thin even in high income countries vaccinating children is unlikely to be a priority. Preliminary data suggest that disease caused by variants of concern remains mild in young children,8910 although close monitoring of newly emerging variants remains essential. Were one to emerge that caused severe disease in children (like Middle East respiratory syndrome), vaccinating children would become a priority.…”

Section: Protectionmentioning

confidence: 99%

Vaccinating children against SARS-CoV-2

Lavine

Bjørnstad

Antia

2021

BMJ

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Following widespread vaccination against SARS-CoV-2 of older adults and other highly vulnerable groups, some high income countries are now considering vaccinating children; just days ago, the US Food and Drug Administration authorized the use of the Pfizer/BioNTech vaccine in children 12-15 years of age. Young people have been largely spared from severe covid-19 so far, 1 2 and the value of childhood vaccination against respiratory viruses in general remains an open question for three reasons: the limited benefits of protection in age groups that experience only mild disease 3 ; the limited effects on transmission because of the range of antigenic types and waning vaccine induced immunity 4 ; and the possibility of unintended consequences related to differences in vaccine induced and infection induced immunity. 5 We discuss each in turn.

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“…Indeed, most reports indicate that while children are equally likely to become infected with SARS-CoV-2, the disease is mild for a large majority of pediatric cases (3). As such, the COVID-19 mortality rate in the United States is 0.34 per 100,000 population and 0.16 per 100,000 for children aged 0-4 and 5-14 years, respectively (4). In stark contrast, the overall COVID-19 mortality rate is 91.5 per 100,000 population in adults, with the highest rate for those aged 85 years and older (1,797.8 per 100,000) (5).…”

Section: Identification Of Mis-c In Sars-cov-2 Infected Childrenmentioning

confidence: 99%

Zonulin as a biomarker and potential therapeutic target in multisystem inflammatory syndrome in children

Hensley-McBain¹,

Manuzak²

2021

Journal of Clinical Investigation

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Multisystem inflammatory syndrome in children (MIS-C) occurs during, or recently following SARS-CoV-2 infection and is characterized by persistent fever, inflammation and severe illness requiring hospitalization. The majority of MIS-C cases also present with gastrointestinal (GI) symptoms, including abdominal pain, vomiting and diarrhea. In a recent issue of the JCI, Yonker and Gilboa et al., identify zonulin as a biomarker of GI permeability in children with MIS-C, and present the results of an intriguing proof-of-concept study which suggests that zonulin may represent a potential therapeutic target for MIS-C treatment and prevention. Together, these findings suggest that intestinal mucosal dysfunction and epithelial barrier breakdown may represent a biological mechanism underlying the development of MIS-C in SARS-CoV-2-infected children.

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Children and young people remain at low risk of COVID-19 mortality

Cited by 262 publications

References 6 publications

Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy

Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy

Vaccinating children against SARS-CoV-2

Zonulin as a biomarker and potential therapeutic target in multisystem inflammatory syndrome in children

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