Children with adrenergic manifestations of envenomation after Tityus serrulatus scorpion sting are protected from early anaphylactic antivenom reactions

Amaral, Carlos Faria Santos; Dias, Mariana Borges; Campolina, Daniel; Proietti, Fernando Augusto; Rezende, Nilton Alves de

doi:10.1016/0041-0101(94)90110-4

Cited by 34 publications

(16 citation statements)

References 14 publications

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“…Our study confirms these previous publications that the singular clinical pictures observed in Santar em region are completely different and are compatible with an acute cerebellar dysfunction with abnormal muscular movements, which is not a characteristic of any other scorpion envenoming in the world (Amaral et al, 1991;Amaral et al, 1994;Brasil, 1998;Cupo et., 2009).…”

Section: Discussionsupporting

confidence: 81%

“…Clinical manifestations caused by scorpion envenomation may be related to other involvement of the nervous and/or muscular system such as psychomotor agitation, somnolence, tremors, mental confusion, seizures and muscle contractions that have been reported in other regions of Brazil (Amaral et al, 1991;Amaral et al, 1994;Brasil, 1998;Cupo et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

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Estudo clínico-epidemiológico, laboratorial e de vulnerabilidade dos acidentes escorpiônicos atendidos no Hospital Municipal de Santarém - Pará

Torrez¹,

Pascuala²

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AGRADECIMENTOSAgradeço a Deus por ter permitido a não abandonar esta longa caminhada longe de casa e que permitiu fazer do Brasil meu lar. Therefore, the study highlights the particularities of scorpionism in Santarem and the most important aspects of vulnerability of these patients.Key-words: Scorpion sting, cerebellar ataxia, rhabdomyolysis, health vulnerability, socioeconomic factor, Amazon region. INTRODUÇÃO

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Estudo clínico-epidemiológico, laboratorial e de vulnerabilidade dos acidentes escorpiônicos atendidos no Hospital Municipal de Santarém - Pará

Torrez¹,

Pascuala²

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“…Serum glucose level increased after M. tamulus gangeticus envenomation, resulting in hyperglycemia. This could be due to reduced insulin secretion, excessive release of catecholamines, decreased thyroid hormone levels, and increased cortisol and glucagon levels observed during earlier studies with other scorpion species (5,14,15,27). Reduced insulin and increased glucagon secretion causes a sustained fall in glucose clearance and promotes glycogenolysis and gluconeogenesis, thereby increasing blood glucose levels (28).…”

Section: Discussionmentioning

confidence: 96%

Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice

Chaubey¹

2010

J. Venom. Anim. Toxins incl. Trop. Dis

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The present study aimed to investigate the effects of Mesobuthus tamulus gangeticus Pocock (Buthidae) venom on albino mice (NIH strain). Whole venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. The venom LD50 was 2.5 mg kg-1 of mouse body weight. Toxic effects on different biochemical and enzymatic parameters in blood serum and other tissues of albino mice were determined after experimental envenomation with sublethal doses of M. tamulus gangeticus venom. Increased levels of glucose, uric acid and cholesterol, as well as decreased serum total proteins, were observed at 2 and 4 hours after the envenomation. In the liver and muscles, glycogen content dropped after venom injection. Moreover, M. tamulus gangeticus venom elevated the enzymatic activity of acid phosphatase (ACP), lactic dehydrogenase (LDH) and alanine aminotransferase (ALT) in the serum of albino mice. In conclusion, M. tamulus gangeticus can be considered a lethal scorpion species

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“…[ 5 ] Circulating endogenous catecholamine itself acts as prophylaxis against anaphylaxis because of which anaphylaxis to SAV is rarely seen or absent. [ 6 7 ] Venom-induced anaphylaxis could be one of the differentials but its presentation nearly 3 h after the bite makes it very unlikely. Furthermore, the first dose effect of prazosin can cause severe hypotension but the accompanying bronchospasm and edema makes anaphylaxis more plausible.…”

Section: Discussionmentioning

confidence: 99%

Anaphylaxis to scorpion antivenin and its management following envenomation by Indian red scorpion, Mesobuthus tamulus

Bhoite¹,

Bhoite

Bagdure

et al. 2015

Indian Journal of Critical Care Medicine

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Mesobuthus tamulus is an Indian red scorpion that is responsible for numerous cases of scorpion stings in the Indian subcontinent. Antivenin, vasodilators, and benzodiazepines are medications of choice in the treatment of scorpion bites. Adverse reactions such as anaphylaxis to antivenin have been infrequently described in the literature. We, herein, present a case of a 42-year-old man stung by Indian red scorpion while gardening at home in India, who presented with extreme pain at the sting site and signs of cardio-toxicity. He was treated with scorpion antivenin and vasodilators but developed anaphylaxis to antivenin. We discuss management strategies. Anaphylaxis to antivenin should be on the differential during management of scorpion bites because classical signs of anaphylaxis may be absent.

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Children with adrenergic manifestations of envenomation after Tityus serrulatus scorpion sting are protected from early anaphylactic antivenom reactions

Cited by 34 publications

References 14 publications

Estudo clínico-epidemiológico, laboratorial e de vulnerabilidade dos acidentes escorpiônicos atendidos no Hospital Municipal de Santarém - Pará

Estudo clínico-epidemiológico, laboratorial e de vulnerabilidade dos acidentes escorpiônicos atendidos no Hospital Municipal de Santarém - Pará

Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice

Anaphylaxis to scorpion antivenin and its management following envenomation by Indian red scorpion, Mesobuthus tamulus

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