Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines

Russo, Alessandra; Cardile, Venera; Sánchez, F; Troncoso, Nicolas; Vanella, A.; Garbarino, Juan A.

doi:10.1016/j.lfs.2004.07.019

Cited by 123 publications

(102 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study provided results which showed significant inhibition of HT29 colon cancer cells by both Nenas and Gelam honeys, with the latter having higher potential as anti-tumor dietary agent. High polyphenols in honey has been attributed for its anti-tumor property (Russo et al, 2004;Jaganathan & Mandal, 2009 a ) The present and previous study showed that both Gelam and Nenas honeys have high levels of total phenolic compound which correlated significantly with their antioxidant activity (Hussein et al, 2010). Thus, it is highly probable that the high potency of Gelam honey in curbing the growth of HT29 colon adenocarcinoma cells is mainly due to high phenolic compounds it contained.…”

Section: Malaysia Is Known For Its Wide Variety Of Honeys Either Honementioning

confidence: 60%

“…To our knowledge no experimental evidences to date have shown the association of honey in inducing DNA damage in colon cancer cells. However, a close relative of honey, propolis extract which is rich in flavanoids, galangin and caffeic acid was also shown to cause dose-dependent DNA damage on Caco-2 colon adenocarcinoma cells after 72 hours of treatment (Russo et al, 2004).…”

Section: Malaysia Is Known For Its Wide Variety Of Honeys Either Honementioning

confidence: 99%

See 1 more Smart Citation

Gelam and Nenas Honeys Inhibit Proliferation of HT 29 Colon Cancer Cells by Inducing DNA Damage and Apoptosis while Suppressing Inflammation

Wen¹,

Hussein²,

Abdullah³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Malaysia Is Known For Its Wide Variety Of Honeys Either Honementioning

confidence: 60%

Section: Malaysia Is Known For Its Wide Variety Of Honeys Either Honementioning

confidence: 99%

Gelam and Nenas Honeys Inhibit Proliferation of HT 29 Colon Cancer Cells by Inducing DNA Damage and Apoptosis while Suppressing Inflammation

Wen¹,

Hussein²,

Abdullah³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…According to Valente et al (2010) the phenolic compounds and their derivatives act as excellent antioxidants, playing the role of an efficient free radical scavenger, metal ion chelator, and free radical inhibitor and eliminator (RUSSO et al, 2004), hence preventing lipid oxidation. Thus propolis could be a source of natural antioxidant compounds with great application in the food industry.…”

Section: Introductionmentioning

confidence: 99%

Application and evaluation of propolis, the natural antioxidant in Italian-type salami

Kunrath¹,

Savoldi²,

Mileski³

et al. 2017

Braz. J. Food Technol.

View full text Add to dashboard Cite

Application and evaluation of propolis, the natural antioxidant in Italian-type salami Aplicação e avaliação de própolis, o antioxidante natural, em salame tipo Italiano SummaryThis study aimed to characterize propolis with respect to its antioxidant activity and apply it to the elaboration of Italian-type salami. A propolis sample was collected and subjected to chemical and physicochemical characterization and its antioxidant capacity determined. Four salami formulations were developed: F1 (no antioxidants); F2 (addition of 0.01% BHT); F3 (addition of 0.01% propolis) and F4 (addition of 0.05% propolis). The salamis were evaluated with respect to their physicochemical properties and lipid oxidation. The characterization of the propolis showed a high level of waxes and low levels of phenolic compounds and flavonoids, although in sufficient quantity to prove their antioxidant activity. The Italian-type salamis showed moisture, protein and lipid contents which conformed to the limits preconized by Brazilian legislation. The F4 formulation (0.05% propolis) showed a better result when compared to the formulations F3 (0.01% propolis) and F1 (no antioxidant). However, formulation F2 (0.01% BHT) showed the lowest value of lipid oxidation. The results showed that propolis inhibits oxidative action and can be added to meat products as a natural antioxidant. Keywords: Meat products; Shelf life; Lipid oxidation. ResumoO presente estudo teve por finalidade caracterizar a própolis quanto à sua atividade antioxidante e aplicá-la na elaboração de salame tipo italiano. Amostra de própolis foi coletada e submetida à caracterização físico-química, química e capacidade antioxidante. Quatro formulações de salame foram elaboradas: F1 (sem antioxidante), F2 (adição BHT 0,01%), F3 (adição de própolis 0,01%) e F4 (adição de própolis 0,05%). Os salames foram avaliados quanto às propriedades físico-químicas e oxidação lipídica. A caracterização da própolis mostrou alto teor de ceras e baixo teor de compostos fenólicos e flavonoides, porém em quantidades suficientes para comprovar sua atividade antioxidante. Os salames tipo italiano apresentaram teor de umidade, proteínas e lipídeos conforme limites preconizados pela legislação brasileira. A formulação F4 (0,05% de própolis) apresentou melhor resultado quando comparado às formulações F3 (0,01% de própolis) e F1 (sem antioxidante). No entanto, a F2 (0,01% de BHT) foi a formulação que apresentou menor valor de oxidação lipídica. Os resultados demonstraram que a própolis inibe a ação oxidativa, podendo ser adicionada em produtos cárneos como antioxidante natural. Palavras-chave: Produtos cárneos; Prazo de validade; Oxidação lipídica.

show abstract

“…Additionally, a report suggests antioxidant properties of propolis using different chemical assays such as scavenging of DPPH radical [4] and superoxide anion [5], may vary due to the differences in the chemical composition of propolis, which depends on its origin of the propolis [6].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and antioxidant activities of Trigona Apicalis propolis extract

Rosli¹,

Roslan²,

Omar³

et al. 2016

AIP Conference Proceedings

View full text Add to dashboard Cite

Abstract. Propolis is a resinous substance found in beehives. It provides beneficial effects on human health and has been used to treat many diseases since ancient times. The objectives of this study were to analyze the phytochemical profile of propolis derived from local T. apicalis species and its antioxidant activities. The ethanolic extract of propolis was subjected to HPLC analysis to analyze its phytochemical profile. The propolis extract was later tested for antioxidant capacities by using DPPH radical scavenging assay. TPC and TFC were performed to determine the correlation with its antioxidant activities. TEAC for each serial dilution sample was 2621.15 (4.76 mg/mL), 2050.85 (2.38 mg/mL), 1883.27 (1.19 mg/mL), 1562.67 (0.59 mg/mL), 1327.82 (0.29 mg/mL), 1164.49 (0.15 mg/mL), 983.27 (0.07 mg/mL), and 944.79 (0.04 mg/mL). The results demonstrated that the antioxidant activities of propolis extract were dose dependent. The IC50 of propolis for DPPH assay was 4.27 mg/ml. Correlation values of TPC and TFC against DPPH indicate that the antioxidant activities of propolis extract used in this study could be mainly influenced by the phenolic and flavonoid contents. These findings highlighted the importance of quality analysis in order to ensure the consistency of biological effects or therapy of a natural product, such as propolis.

show abstract

Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines

Cited by 123 publications

References 45 publications

Gelam and Nenas Honeys Inhibit Proliferation of HT 29 Colon Cancer Cells by Inducing DNA Damage and Apoptosis while Suppressing Inflammation

Gelam and Nenas Honeys Inhibit Proliferation of HT 29 Colon Cancer Cells by Inducing DNA Damage and Apoptosis while Suppressing Inflammation

Application and evaluation of propolis, the natural antioxidant in Italian-type salami

Phytochemical analysis and antioxidant activities of Trigona Apicalis propolis extract

Contact Info

Product

Resources

About