CHIME - A tailored HCV microelimination project in Viennese people who inject drugs at drug centralized substitution centers

Schwarz, Caroline; Schubert, Raphael; Schwarz, Michael; Schütz, Angelika; Jenke, Andreas; Bauer, Dávid; Steinwender, Benjamin; Gutic, E; Reiberger, T; Haltmayer, Hans; Gschwantler, Michael

doi:10.1016/j.jve.2023.100338

Journal of Virus Eradication

2023

DOI: 10.1016/j.jve.2023.100338

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CHIME - A tailored HCV microelimination project in Viennese people who inject drugs at drug centralized substitution centers

Caroline Schwarz¹,

Raphael Schubert²,

Michael Schwarz³

et al.

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2024

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A systematic PCR record‐based re‐call of HCV‐RNA‐positive people enables re‐linkage to care and HCV elimination in Austria — The ELIMINATE project

Balcar,

Schwarz,

Dorn

et al. 2024

Liver International

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Background and AimsIdentification of people living with hepatitis C virus (HCV) via readily available laboratory records could be a key strategy for macro‐elimination, aligning with the WHO elimination goal. Therefore, the ELIMINATE(ELIMINation of HCV in AusTria East) project aimed to systematically re‐link people with a ‘last‐positive’ HCV‐RNA PCR record to care.MethodsIn 10 major liver centres in Eastern Austria, a systematic readout of ‘last‐positive’ HCV‐RNA PCR test records obtained between 2008 and 2020 were conducted and linked to available patient contact data. Between 2020 and 2023, individuals were contacted first by phone, then by letter, to inform them about the availability of effective direct‐acting antiviral (DAA) treatment and invite them for pre‐treatment evaluation.ResultsThe overall cohort of last‐positive HCV+ individuals included 5695 subjects (62.5% males, mean age 57.3 ± 17.3 years); of note, 1931 (34%) of them had died and 759 (13%) individuals had no valid contact information. Of the remaining 3005 individuals, 1171 (40.0%) had already achieved sustained virological response (SVR) at the time of re‐call. We successfully reached 617 (20.5%), of whom 417 (67.6%) attended their pre‐treatment visit, and 397 (64.3%) commenced DAA‐therapy. HCV cure has been confirmed in 326 individuals, corresponding to an SVR rate of 82.1%.ConclusionThe ELIMINATE project identified 5695 people living with HCV who were ‘lost to care’ despite documented HCV viraemia. While invalid contact data were an evident barrier to HCV elimination, premature deaths among the cohort underscored the severity of untreated HCV. The implementation of a systematic HCV‐RNA PCR recorded‐based re‐call workflow represents an effective strategy supporting the WHO goal of HCV elimination.

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A systematic PCR record‐based re‐call of HCV‐RNA‐positive people enables re‐linkage to care and HCV elimination in Austria — The ELIMINATE project

Balcar,

Schwarz,

Dorn

et al. 2024

Liver International

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CHIME - A tailored HCV microelimination project in Viennese people who inject drugs at drug centralized substitution centers

Cited by 1 publication

References 43 publications

A systematic PCR record‐based re‐call of HCV‐RNA‐positive people enables re‐linkage to care and HCV elimination in Austria — The ELIMINATE project

A systematic PCR record‐based re‐call of HCV‐RNA‐positive people enables re‐linkage to care and HCV elimination in Austria — The ELIMINATE project

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