2024
DOI: 10.1101/2024.05.29.596406
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Chimeric Origins and Dynamic Evolution of Central Carbon Metabolism in Eukaryotes

Carlos Santana Molina,
Tom A Williams,
Berend Snel
et al.

Abstract: The origin of eukaryotes was a key event in the history of life. Current leading hypotheses propose that a symbiosis between an asgardarchaeal host cell and an alphaproteobacterial endosymbiont represented a crucial step in eukaryotic origins and invoke a central role for syntrophic interactions - that is, metabolic cross-feeding between the partners as the basis for their subsequent evolutionary integration. A major unanswered question is whether the metabolism of modern eukaryotes bears any vestige of this a… Show more

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“…The underlying reason for this observation is unclear. Yet, more likely, and in congruence with recent work showing that eukaryotic central carbon metabolic pathways are in part of Asgard archaeal origin ( 59 ), these metabolic iESPs represent ancient homologs of eukaryotic proteins that have evolved beyond the limit of reliable sequence similarity detection. Altogether, our analyses suggest that a thus far underappreciated fraction of the eukaryotic metabolic repertoire is of Asgard archaeal provenance.…”
Section: Discussionsupporting
confidence: 59%
“…The underlying reason for this observation is unclear. Yet, more likely, and in congruence with recent work showing that eukaryotic central carbon metabolic pathways are in part of Asgard archaeal origin ( 59 ), these metabolic iESPs represent ancient homologs of eukaryotic proteins that have evolved beyond the limit of reliable sequence similarity detection. Altogether, our analyses suggest that a thus far underappreciated fraction of the eukaryotic metabolic repertoire is of Asgard archaeal provenance.…”
Section: Discussionsupporting
confidence: 59%