Chin Numbness: A Symptom That Should Not be Underestimated: A Review of 12 Cases

Colella, Giuseppe; Giudice, Amerigo; Falcone, Umberto; Siniscalchi, Giovanni; Guastafierro, Salvatore

doi:10.1097/maj.0b013e31819299fa

Cited by 32 publications

(20 citation statements)

References 24 publications

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“…Further cases of V 3 sensory neuropathies among women with breast cancer have been reported more recently. 1 Lymphomas, breast and lung cancers are however, by far, the most frequently reported. 15 No sex predominance is found, the occurrence being due to the sex distribution of the underlining tumours.…”

Section: Neoplasiamentioning

confidence: 98%

An update on the causes, assessment and management of third division sensory trigeminal neuropathies

et al. 2016

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Introduction Sensory neuropathies of the mandibular division of the trigeminal (V3) nerve can be debilitating, causing difficulty with daily function. It has a variety of causes, including iatrogenic injury, usually caused by third molar removal, local anaesthetic administration, implant placement or endodontic treatment. Non-iatrogenic causes include infection, primary or secondary neoplasia and various medical conditions.Objective To review the aetiology, evaluation and management of V3 neuropathy in a retrospective case-series of patients referred to a specialist nerve injury clinic over an eight-year period, particularly focusing on the non-iatrogenic causes of this presentation.Methods A retrospective analysis of the case notes of 372 patients referred to the specialist nerve injury clinic between 2006 and 2014 was carried out to establish the cause of the neuropathy and subsequent management or referral. The assessment protocol of trigeminal neuropathy used in the clinic is also outlined.Results Most patients (89.5%) presented with neuropathy due to iatrogenic injury. Of the non-iatrogenic causes (10.5%), malignancy accounted for a fifth of presentations, and infection almost two-fifths, demonstrating the importance of prompt identification of a cause and management by the clinician, or referral to the appropriate specialty. Other, more rare causes are also presented, including multiple sclerosis, sickle-cell anaemia and Paget's disease, highlighting the importance to the clinician of considering differential diagnoses.Conclusions This case series demonstrates the less frequent, but nevertheless important, non-iatrogenic causes which clinicians should consider when assessing patients with trigeminal neuropathy.

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Section: Neoplasiamentioning

confidence: 98%

An update on the causes, assessment and management of third division sensory trigeminal neuropathies

et al. 2016

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“…Recognising NCS clinically is important as this may be a subtle sign of occult malignancy progression or relapses 3 4. Current expert opinion is that patients with NCS without apparent cause should be assumed to have a malignant aetiology until proven otherwise 5. By far the most common non-haematologic neoplastic cause of NCS is breast cancer, while the most common haematologic neoplastic cause is Hodgkin lymphoma (NHL) 6.…”

Section: Introductionmentioning

confidence: 99%

Non-Hodgkin lymphoma presenting with numb chin syndrome

Fan

Luka²,

Noronha³

2011

Case Reports

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“…It is characterised by facial numbness along the distribution of the mental branch of the trigeminal nerve. Most cases of this syndrome that are not dental in origin have been associated with malignant tumours or diffuse metastatic disease 5. The sign of mental nerve neuropathy should be considered as a significant sinister symptom and clinicians should be aware of mandible being a potential site of metastasis in colorectal cancer and such cases should be further investigated accordingly.…”

Section: Discussionmentioning

confidence: 99%