The rapid pace of industrialization and sectoral transformation have not only induced rapid economic progress yet also engaged policy think tanks to consider the safety performance due to the increasing rate of injuries. These increasing workplace hazards have affected occupational efficiencies as well as worker’s performance. Hence, a comprehensive analysis of occupation injuries of workers (OIW) is crucial to determine the safety performance of high and low-risk industries in Pakistan. This study aims to incorporate the OIW for the estimation of the safety performance of industries employing Data Envelopment Analysis (DEA). This non-parametric technique allows calculating relative efficiencies incorporating inputs and outputs (both desirable and undesirable). The findings of the SBM-DEA model and sensitivity analyses pointed out improvements in the farm sector and demanded more comprehensive analyses for the non-farm sectors.