Chinese herbal decoction of Wenshen Yangxue formula improved fertility and pregnancy rate in mice through PI3K/Akt signaling

Xin, Mingwei; He, Junqi; Zhang, Ying; Wu, Ying; Yang, Wei; Liang, Xinyun; Yin, Xiaoyi

doi:10.1002/jcb.27483

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…Several reports have suggested that traditional herbal formulas and medicinal herbs successfully improve endometrial receptivity and might be an alternative option for improving the outcome of embryo implantation [192][193][194]. Many herbal formulas have been studied for enhancing the embryo implantation rate in animal studies and clinical study [195][196][197][198][199][200][201][202][203][204][205][206][207][208][209][210][211][212][213]. Among these formulas, Erbu Zhuyu decoction and Tokishakuyakusan (TJ-23, Danggui Shaoyao san in Chinese) have been reported to induce autophagy via the expression of Beclin1 and LC3 [208,214,215].…”

Section: Possible Role Of Autophagy On the Effect Of Medicinal Herbal Drugs As Embryo Implantation Enhancermentioning

confidence: 99%

“…BaelanChagsangBang -- [236] Bangdeyun and its component DS147 -- [196,197] Buganshen recipe -- [198] BuShenAnTai recipe -- [201] Bushen Tiaoxue Granules and Kunling Wan -- [202] Dingkun Pill -- [206,207,212] Erbu Zhuyu decoction -Increases the Beclin1 and LC3B [204,208] Gushen'antai pills -- [195] Liuwei Dihuang Granule -- [199] Shoutaiwai recipe -- [200] Tokishakuyakusan(Danggui Shaoyao san) -Induces autophagy and mitophagy via increasing PINK1 and LC3 but reducing p62 [203,214,215] Wenshen Yangxue decoction -- [205,211] Xianziyizhen Recipe -- [237] Yeosin-san Paeonia lactiflora and Cyperus rotundus - [213,238] Yiqixue buganshen recipe -- [198] Zhuyun recipe -- [210] Angelica gigas Decusirol Block autophagic flux by suppressing cathepsin C expression [216,221] Cnidium officinale -- [239] Cyperus rotundus -Increases LC3B II/LC3B and Beclin1 [223,229] Paeonia lactiflora Paeoniflorin Induces autophagy via inhibition of AKT/mTOR [114,225,230] Panax quiquefolius (American Ginseng) Ginsenoside Rb1 and Rg1…”

Section: Name Active Components Role In Autophagy Referencesmentioning

confidence: 99%

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Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Park

Cho

et al. 2021

Pharmaceuticals

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Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development. Recent studies have strongly suggested that autophagy in the endometrium is the most important factor for successful embryo implantation. In addition, several studies have reported the effects of various natural products on infertility improvement via the regulation of embryo implantation, embryo quality, and endometrial receptivity. However, it is unclear whether natural products can improve embryo implantation ability by regulating endometrial autophagy. Therefore, we performed a literature review of studies on endometrial autophagy, embryo implantation, natural products, and female infertility. Based on the information from these studies, this review suggests a new treatment strategy for female infertility by proposing natural products that have been proven to be safe and effective as endometrial autophagy regulators; additionally, we provide a comprehensive understanding of the relationship between the regulation of endometrial autophagy by natural products and female infertility, with an emphasis on embryo implantation.

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Section: Possible Role Of Autophagy On the Effect Of Medicinal Herbal Drugs As Embryo Implantation Enhancermentioning

confidence: 99%

Section: Name Active Components Role In Autophagy Referencesmentioning

confidence: 99%

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Park

Cho

et al. 2021

Pharmaceuticals

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“…It is one of the earliest and most widely used dosage forms in Chinese medical practice and has existed for thousands of years [4]. Not only is decoction a relatively fast and cheap process that is readily available to patients, but also the flexible prescription can satisfy the needs of TCM treatment according to syndrome differentiation [5], Nevertheless, how effective the drug prescription is, depends on the quality of decoction [6]. Furthermore, decoction of TCM is a complex system consisting of many components.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive and Rapid Quality Evaluation Method of Traditional Chinese Medicine Decoction by Integrating UPLC-QTOF-MS and UFLC-QQQ-MS and Its Application

Chen

Jiang

et al. 2019

Molecules

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Decoction is one of the oldest forms of traditional Chinese medicine and it is widely used in clinical practice. However, the quality evaluation and control of traditional decoction is a challenge due to the characteristics of complicated constituents, water as solvent, and temporary preparation. ShenFu Prescription Decoction (SFPD) is a classical prescription for preventing and treating many types of cardiovascular disease. In this article, a comprehensive and rapid method for quality evaluation and control of SFPD was developed, via qualitative and quantitative analysis of the major components by integrating ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry and ultra-fast-performance liquid chromatography equipped with triple quadrupole mass spectrometry. Consequently, a total of 39 constituents were tentatively identified in qualitative analysis, of which 21 compounds were unambiguously confirmed by comparing with reference substances. We determined 13 important constituents within 7 min by multiple reaction monitoring. The validated method was applied for determining five different proportion SFPDs. It was found that different proportions generated great influence on the dissolution of constituents. This may be one of the mechanisms for which different proportions play different synergistic effects. Therefore, the developed method is a fast and useful approach for quality evaluation of SFPD.

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“…18,19 A number of studies have revealed that traditional Chinese medicine (TCM) has an important role in the enhancement of the parameters of spermatozoa, including sperm count, viability, motility, and morphology. [20][21][22] Not only can it treat male infertility but it also improves the symptoms of other diseases, such as premature ejaculation, 23 erectile dysfunction. 24 In terms of sperm quality, studies show that the total sperm motility of patients who had received TCM combined with vitamins for twelve weeks is better than those who only received vitamins.…”

mentioning

confidence: 99%

Vitamins combined with traditional Chinese medicine for male infertility: A systematic review and meta‐analysis

Wang

et al. 2020

Andrology

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Background Male infertility is a tough problem in medicine. This article aims to provide the latest evidence for the efficacy and safety of traditional Chinese medicine (TCM) combined with vitamins in the treatment of male infertility. Method All randomized controlled trials (RCTs) that used TCM combined with vitamins for male infertility treatment were included in databases of China National Knowledge Infrastructure (CNKI), Wanfang, VIP Database, China Biology Medicine disc (CBM), MEDLINE, EMBASE, and Cochrane Library. The quality of the included articles was evaluated using the Cochrane Reviewer's Handbook 5.3, and meta‐analysis was performed using Stata 15. Results A total of 14 eligible studies with 1488 patients were included in this meta‐analysis. The results suggested that, compared with vitamin E or vitamin E + C alone, combination of TCM with vitamins increased significantly sperm concentration, sperm motility, sperm viability, liquefaction time of semen, the activity of acrosome enzyme, and the pregnancy rate of patients with male infertility. Three kinds of TCM (Shengjing capsule, Huanshao capsule, and compound Xuanju capsule) showed significant improvement for male infertility in terms of pregnancy rate, sperm concentration, or sperm motility. In addition, the results of the publication bias test demonstrated that no significant bias occurred. Conclusion Traditional Chinese medicine combined with vitamins has significant efficacy in the treatment of male infertility with no increase in side effects. The specific implementing regulations still need more long‐term, multicenter, randomized, and double‐blind clinical trials.

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Chinese herbal decoction of Wenshen Yangxue formula improved fertility and pregnancy rate in mice through PI3K/Akt signaling

Cited by 7 publications

References 24 publications

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

A Comprehensive and Rapid Quality Evaluation Method of Traditional Chinese Medicine Decoction by Integrating UPLC-QTOF-MS and UFLC-QQQ-MS and Its Application

Vitamins combined with traditional Chinese medicine for male infertility: A systematic review and meta‐analysis

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