Chinese Herbal Medicine Banxiaxiexin Decoction Treating Diabetic Gastroparesis: A Systematic Review of Randomized Controlled Trials

Tian, Jiaxing; Li, Min; Liao, Jingqiu; Li, Junling; Tong, Xiaolin

doi:10.1155/2013/749495

Cited by 17 publications

(12 citation statements)

References 24 publications

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“…In the past decades, herb pair has been highly valued as the smallest compatibility units in TCM formula [ 51 ]. HL-BX became a classic herb pair in the treatment of DGP.…”

Section: Discussionmentioning

confidence: 99%

Effects and Components of Herb Pair Huanglian‐Banxia on Diabetic Gastroparesis by Network Pharmacology

Liang

Zhang

Jiang

et al. 2021

BioMed Research International

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Diabetic gastroparesis (DGP) is a serious and chronic complication of long-standing diabetes mellitus, which brings a heavy burden to individuals and society. Traditional Chinese medicine (TCM) is considered a complementary and alternative therapy for DGP patients. Huanglian (Coptidis Rhizoma, HL) and Banxia (Pinelliae Rhizoma, BX) combined as herb pair have been frequently used in TCM prescriptions, which can effectively treat DGP in China. In this article, a practical application of TCM network pharmacological approach was used for the research on herb pair HL-BX in the treatment of DGP. Firstly, twenty-seven potential active components of HL-BX were screened from the TCMSP database, and their potential targets were also retrieved. Then, the compound-target network and PPI network were constructed from predicted common targets, and several key targets were found based on the degree of the network. Next, GO and KEGG enrichment analyses were conducted to obtain several significantly enriched terms. Finally, the experimental verification was made. The results demonstrated that network pharmacological approach was a powerful means for identifying bioactive ingredients and mechanisms of action for TCM. Network pharmacology provided an effective strategy for TCM modern research.

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“…In the past decades, herb pair has been highly valued as the smallest compatibility units in TCM formula [ 51 ]. HL-BX became a classic herb pair in the treatment of DGP.…”

Section: Discussionmentioning

confidence: 99%

Effects and Components of Herb Pair Huanglian‐Banxia on Diabetic Gastroparesis by Network Pharmacology

Liang

Zhang

Jiang

et al. 2021

BioMed Research International

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“…Banxia Xiexin decoction (BXD) consists of seven herbs (Table 2) and is an effective Chinese medicine prescribed for treatment of gastroenteritis, ulcerative colitis, vomiting, and diarrhea (Tian et al, 2013; Wang X. et al, 2014; Wang Y. et al, 2014). Wang Y. et al (2014) successfully used a validated UPLC–MS/MS method to accurately quantitate 18 bioactive compounds in BXD, including flavonoids, alkaloids, and saponins.…”

Section: Herbal Medicines For Treatment and Prevention Of Cpt-11-indumentioning

confidence: 99%

Herbal Medicines for Irinotecan-Induced Diarrhea

Wan

Xiao

et al. 2019

Front. Pharmacol.

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Irinotecan (CPT-11), a water-soluble derivative of camptothecin, belongs to the class of DNA topoisomerase I inhibitors and has been approved worldwide for the treatment of advanced colorectal cancer, lung cancer, and malignant lymphoma. Although CPT-11-based chemotherapy is widely used, severe gastrointestinal (GI) toxicity, especially late-onset diarrhea, is a common adverse reaction, limiting clinical application of the drug. The incidence of grade 3 or 4 diarrhea is high, with 20–40% of CPT-11-treated patients experiencing this adverse effect. High-dose loperamide and octreotide are generally recommended for treatment of CPT-11-induced diarrhea. However, in clinical practice, loperamide is associated with a significant failure rate and the beneficial effects of octreotide are controversial. An accumulating number of recent studies have suggested that medicinal herbs and their derived phytocompounds may be effective complementary treatments for CPT-11-induced diarrhea. In this mini-review, we briefly summarize currently available literatures regarding the formulae and herbs/natural products used as adjuvants in animal and clinical studies for the treatment of diarrhea caused by CPT-11.

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“…A recent review of the literature indicated that only small studies have so far been published, from which no definite efficacy or safety conclusions could be made. 56 …”

Section: Banxiaxiexin Decoctionmentioning

confidence: 99%