Chinese Herbal Medicine for the Treatment of Drug Addiction

Zhu, Weili; Zhang, Yinan; Huang, Yingjie; Lü, Lin

doi:10.1016/bs.irn.2017.02.013

Cited by 36 publications

(32 citation statements)

References 68 publications

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“…2. Miltirone partly inhibits upsurge in mRNA levels of the a 4 subunit of GABA that was persuaded through ethanol withdrawal in cultured hippocampal neurons (Mostallino et al, 2004;Zhu et al, 2017). 3.…”

Section: Methodsmentioning

confidence: 99%

“…lobata (Willd.) Maesen & S.M.Almeida ex Sanjappa & Predeep, iboganine from Tabernanthe iboga Baill., tanshinones I and II, cryptotanshinone, and miltirone from Salvia miltiorrhiza Bunge, hyperforin from Hypericum perforatum L., ginsenosides from Panax ginseng C.A.Mey., and withanolide D and withaferin A from Withania somnifera (L.) Dunal etc., that are some of the widely studied and well-known species suppressing alcohol intake in experimental animals (Sweetnam et al, 1995;Butterweck et al, 1997;Rezvani et al, 2002;Abenavoli et al, 2009;Zhu et al, 2017). These substances are known to put forth their effects by influencing several of the neurological systems, thereby suppressing drinking behavior.…”

Section: Ethnopharmacological Applications Targeting Alcohol Abusementioning

confidence: 99%

“…Protects liver and kidney damage caused by alcohol intake by counteracting the enzyme inhibition (Glen et al, 1987;Abenavoli et al, 2009;Tomczyk et al, 2012) contribution, review article or key editorial note), were taken into consideration. An outline of the various plants species used for prevention and management against alcohol abuse is presented in (Zhu et al, 2017). Apart from this, the species finds its utility in treatment of fevers, muscle aches, gastrointestinal disorders, skin problems, allergies, high blood pressure, and chronic alcoholism (Lee et al, 1999;Abascal and Yarnell, 2007).…”

Section: Kava Lactonesmentioning

confidence: 99%

“…Likewise, L-Stepholidine, an alkaloid extract of the Chinese herb Stephania intermedia H.S. Lo, helps to control morphine-preference and induces reinstatement (Zhu et al, 2017).…”

Section: Red Sagementioning

confidence: 99%

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Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

et al. 2020

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Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self-restraint and prevent relapse, but they have many side effects. Natural products are most promising as they cause fewer adverse effects. Here we discuss in detail the medicinal plants used in various traditional/folklore medicine systems for targeting alcohol abuse. We also comprehensively describe preclinical and clinical studies done on some of these plants along with the possible mechanisms of action.

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Section: Methodsmentioning

confidence: 99%

Section: Ethnopharmacological Applications Targeting Alcohol Abusementioning

confidence: 99%

Section: Kava Lactonesmentioning

confidence: 99%

“…Likewise, L-Stepholidine, an alkaloid extract of the Chinese herb Stephania intermedia H.S. Lo, helps to control morphine-preference and induces reinstatement (Zhu et al, 2017).…”

Section: Red Sagementioning

confidence: 99%

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Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

et al. 2020

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“…Moreover, the effectiveness of OAT is limited by difficulties at all levels of the therapeutic process, such as diagnosis, entry, and persistence of the patients on treatment; it also needs training health care professionals for the treatment and prevention of opioid abstinence syndrome during the therapy [1]. In this regard, there is an increased interest in alternative pharmacotherapy modalities for opioid addiction among health care providers and patients [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Determination of Common Pharmaceutical Adulterants in Herbal Medicinal Products Used in the Treatment of Opioid Addiction

Shiri-Ghaleh

Moradi

Soltaninejad

2019

Int J Med Toxicol Forensic Med

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Background: Opioid addiction is a serious and growing global concern. Recently, herbal medicine has been popular for the treatment of opioid abusers worldwide. Unfortunately, the adulteration of herbal remedies with undeclared synthetic pharmaceuticals has been reported. In Iran, there are few reports on the adulteration of herbal remedies by synthetic pharmaceuticals sold as opioid addiction treatment. The aim of this study was to analyze herbal products used in opioid addiction treatment for the identification of synthetic pharmaceuticals as adulterants in the remedies.Methods: Forty commonly-used handmade herbal products for the treatment of opioid addiction were collected from herbal shops in Kermanshah (western area of Iran). After organoleptic examinations, the samples were prepared and analyzed by high-performance liquid chromatography and gas chromatography-mass spectrometry for detecting probable synthetic pharmaceutical adulterants.Results: The chromatographic analysis of the samples showed that 90% of the products had at least one undeclared pharmaceutical ingredient as an adulterant. The majority of the samples (n=19, 47.5%) had only one undeclared pharmaceutical. Diphenoxylate (n=24, 39.3%), tramadol (n=16, 26.2), methadone (n=8, 13.2%), and the combination of these drugs were reported as common adulterants. We detected the presence of buprenorphine and sildenafil as adulterating agents in the herbal formulations for the first time.Conclusion: According to the presence of undeclared synthetic pharmaceuticals in opioid addiction herbal products, as well as their threats to public health, awareness, in this case, is necessary.

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Natural Products for the Treatment of Drug Addiction: Narrative Review

Raslan

2022

Chemistry & Biodiversity

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Drug addiction is considered a chronic disorder affecting the individual's life, his/her family and society. Up till now the treatment of drug addiction is considered a problematic issue. Synthetic drugs available for the treatment of drug addiction are few, of limited efficacy and associated with serious side effects. Therefore, there is a continuous search for better therapeutic agents for drug addiction. Natural products represent a promising source for drug addiction treatment. This review summaries drug addiction definition, its mechanism of action, its types, its diagnosis, factors affecting its development and different available approaches for its treatment especially the use of natural products. Six plants were discussed thoroughly in this review, including, Tabernanthe

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Chinese Herbal Medicine for the Treatment of Drug Addiction

Cited by 36 publications

References 68 publications

Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

Determination of Common Pharmaceutical Adulterants in Herbal Medicinal Products Used in the Treatment of Opioid Addiction

Natural Products for the Treatment of Drug Addiction: Narrative Review

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