Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study

Huang, Chia-Yu; Wu, Mei-Yao; Kuo, Yu‐Hung; Tou, Sio-Ian; Yen, Hung-Rong

doi:10.1177/1534735420943280

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…A nationwide, population-based, 1:1 propensity scorematched cohort study by Insurance Database 2000, 21,24,25 which contains all of the original claims data of 1 million beneficiaries randomly sampled from the registry of all beneficiaries in 2000, was our data source. 22 There was no significant difference in our sample and the general population in age, sex, birth year, or average insured payroll-related costs.…”

Section: Data Sourcesmentioning

confidence: 99%

“…20 Since 1996, traditional Chinese medicine (TCM) services have been reimbursed through the NHI program, which covers more than 99% of the Taiwanese population. 21,22 All of the claims data were deidentified and then stored in the Taiwanese National Health Insurance Research Database (NHIRD) for research purpose. 20 The large-scale real-world data without sampling bias is one of the advantages of this database.…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

Huang

Sun

et al. 2021

NDT

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Background: Major depressive disorder is a significant public health concern, which often leads to loss of productivity, functional decline, and various complications. The aim of this study was to investigate the effectiveness of acupuncture in the risk reduction of coronary heart disease (CHD) in patients with depression. Methods: We enrolled patients diagnosed with depression between January 1, 1997, and December 31, 2010, through the Taiwanese National Health Insurance Research Database (NHIRD). Propensity score was used to match equal numbers (n=14,647) of acupuncture cohort and no-acupuncture cohort based on characteristics including sex, age, baseline comorbidity and medication. Patients were followed up until December 31, 2013, or withdrawn from the NHIRD. The Cox regression model was used to compare the hazard ratios (HRs) of CHD in the two cohorts. Results: The basic characteristics of the two groups were similar. A lower cumulative incidence of CHD was noted in the acupuncture cohort (Log rank test, p < 0.001). Over time, 1626 patients in the acupuncture cohort (21.05 per 1000 person-years) and 2412 patients in the no-acupuncture cohort (39.84 per 1000 person-years) developed CHD (adjusted HR=0.50, 95% CI 0.47-0.53). The decreased CHD incidence was independent of age, sex, comorbidities, and medications used. The cumulative incidence of CHD was significantly lower in the acupuncture cohort than in the no-acupuncture cohort (Log rank test, p<0.001). Conclusion:The results provided a real-world evidence that acupuncture may have beneficial effect on CHD risk reduction in patients with depression.

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Section: Data Sourcesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

Huang

Sun

et al. 2021

NDT

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“…In other words, the medical data in the NHIRD cover a long enough time and are large enough to be used for nationwide population research. Sampling bias could be prevented when the study is conducted through such a large-scale database 29. We used the NHIRD to investigate the long-term effect of ischaemic stroke prevention in patients with RA who accepted acupuncture treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Sampling bias could be prevented when the study is conducted through such a large-scale database. 29 We used the NHIRD to investigate the long-term effect of ischaemic stroke prevention in patients with RA who accepted acupuncture treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of acupuncture on ischaemic stroke in patients with rheumatoid arthritis: a nationwide propensity score-matched study

Huang,

Liao

et al. 2024

BMJ Open

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ObjectiveTo demonstrate that acupuncture is beneficial for decreasing the risk of ischaemic stroke in patients with rheumatoid arthritis (RA).DesignA propensity score-matched cohort study.SettingA nationwide population-based study.ParticipantsPatients with RA diagnosed between 1 January 1997 and 31 December 2010, through the National Health Insurance Research Database in Taiwan.InterventionsPatients who were administered acupuncture therapy from the initial date of RA diagnosis to 31 December 2010 were included in the acupuncture cohort. Patients who did not receive acupuncture treatment during the same time interval constituted the no-acupuncture cohort.Primary outcome measuresA Cox regression model was used to adjust for age, sex, comorbidities, and types of drugs used. We compared the subhazard ratios (SHRs) of ischaemic stroke between these two cohorts through competing-risks regression models.ResultsAfter 1:1 propensity score matching, a total of 23 226 patients with newly diagnosed RA were equally subgrouped into acupuncture cohort or no-acupuncture cohort according to their use of acupuncture. The basic characteristics of these patients were similar. A lower cumulative incidence of ischaemic stroke was found in the acupuncture cohort (log-rank test, p<0.001; immortal time (period from initial diagnosis of RA to index date) 1065 days; mean number of acupuncture visits 9.83. In the end, 341 patients in the acupuncture cohort (5.95 per 1000 person-years) and 605 patients in the no-acupuncture cohort (12.4 per 1000 person-years) experienced ischaemic stroke (adjusted SHR 0.57, 95% CI 0.50 to 0.65). The advantage of lowering ischaemic stroke incidence through acupuncture therapy in RA patients was independent of sex, age, types of drugs used, and comorbidities.ConclusionsThis study showed the beneficial effect of acupuncture in reducing the incidence of ischaemic stroke in patients with RA.

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“…It has also been widely applied for adjuvant cancer treatment in Asian countries due to its anticancer effects proven by clinical response and evidence. 13,14 Recently, more and more literature indicated that CHM could enhance immunomodulatory activities, 15,16 inhibit carcinogenic properties, 17 prolong survival time, 18-22 alleviate side effects of chemotherapy and radiotherapy, 13 and improve the quality of life 12 in cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Adjunctive Chinese Herbal Medicine Treatment is Associated With an Improved Survival Rate in Patients With Cervical Cancer in Taiwan: A Matched Cohort Study

Wang

Lin

et al. 2021

Integr Cancer Ther

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Background Cervical cancer is one of the most common cancers in Taiwan. Some patients take Chinese herbal medicine (CHM). However, very few current studies have ascertained the usage and efficacy of CHM in patients with cervical cancer. The aim of this study was to investigate the benefits of complementary CHM among patients with cervical cancer in Taiwan. Methods We included the newly diagnosed cervical cancer patients who were registered in the Taiwanese Registry for Catastrophic Illness Patients Database between 2000 and 2010. The end of follow-up period was December 31, 2011. Patients who were less than 20 years old, had missing information for age, withdrew from the National Health Insurance (NHI) program during the follow-up period, or only received other TCM interventions such as acupuncture or tuina massage were excluded from our study. After performing 1:1 frequency matching by age and index date, we enrolled 7521 patients in both CHM and non-CHM user groups. A Cox regression model was used to compare the hazard ratios (HRs) of the risk of mortality. The Kaplan-Meier curve was used to compare the difference in survival time. Results According to the Cox hazard ratio model mutually adjusted for CHM use, age, comorbidity, treatment, and chemotherapeutic agents used, we found that CHM users had a lower hazard ratio of mortality risk (adjusted HR = 0.29, 95%CI = 0.27-0.31). The survival probability was higher for patients in the CHM group. Bai-Hua-She-She-Cao ( Herba Oldenlandiae, synonym Herba Hedyotis diffusae) and Jia-Wei-Xiao-Yao-San were the most commonly prescribed single herb and Chinese herbal formula, respectively. Conclusions Adjunctive CHM may have positive effects of reducing mortality rate and improving the survival probability for cervical cancer patients. Further evidence-based pharmacological investigations and clinical trials are warranted to confirm the findings in our study.

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Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study

Cited by 11 publications

References 35 publications

Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

Effect of acupuncture on ischaemic stroke in patients with rheumatoid arthritis: a nationwide propensity score-matched study

Adjunctive Chinese Herbal Medicine Treatment is Associated With an Improved Survival Rate in Patients With Cervical Cancer in Taiwan: A Matched Cohort Study

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