Chinese Herbal Medicines for Restenosis After Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Controlled Trials

Wu, Jiaming; Zhao, Lianyu; Lin, Kan; Lu, Liming; Luo, Chuanjin

doi:10.1089/acm.2018.0516

Cited by 12 publications

(13 citation statements)

References 13 publications

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“…However, PCI may also result in a series of complications, such as traumatic coronary dissection, iatrogenic coronary thrombosis, and coronary perforation 3 . Restenosis is the condition that the occlusion of the lumen exceeds 50%, which always occurs during half a year after PCI 4 . Restenosis becomes significant after the introduction of stents in patients with an evidently high morbidity 5 .…”

Section: Introductionmentioning

confidence: 99%

The potential function of SP1 and CPPED1 in restenosis after percutaneous coronary intervention

Wang

Liang

Cai

et al. 2022

Journal of Cardiac Surgery

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Objectives Impacts of molecular pathways have been discussed recently on restenosis after percutaneous coronary intervention (PCI). Hence, this study aimed to explore the impact of calcineurin‐like phosphoesterase domain containing 1 (CPPED1) and specificity protein 1 (SP1) on restenosis after PCI. Methods A carotid balloon injury rat model was established, followed by western blot analysis of SP1 and CPPED1 expression in carotid artery (CA) tissues. After SP1 and CPPED1 were overexpressed, the neointimal hyperplasia and luminal stenosis were assessed. In addition, EPC underwent hypoxia/reoxygenation (H/R) treatment to construct an endothelial injury cell model. Then, cell proliferation, apoptosis, intracellular reactive oxygen species (ROS), and Ca2+ concentration were detected with cell counting kit‐8 (CCK‐8), flow cytometry, Chloromethyl‐2'7'‐dichlorofluorescein diacetate (CM‐H2DCFDA) penetrant, and Fluo‐4 AM staining, respectively. The binding relationship between SP1 and CPPED1 was verified by dual‐luciferase reporter and chromatin immunoprecipitation (ChIP) assays. Results SP1 and CPPED1 were lowly expressed in the model rats with carotid balloon injury. Mechanistically, SP1 bound to the promoter region of CPPED1 to activate CPPED1 expression. Overexpressing SP1 or CPPED1 lowered neointimal formation and restenosis rate, thus promoting the recovery of carotid balloon injury in rats. Meanwhile, SP1 and CPPED1 upregulation reduced ROS levels, Ca2+ concentration, and apoptosis of EPCs, accompanied by accelerated EPC viability. Conclusions SP1 or CPPED1 overexpression reduced neointimal formation and restenosis rate in carotid balloon injury.

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Section: Introductionmentioning

confidence: 99%

The potential function of SP1 and CPPED1 in restenosis after percutaneous coronary intervention

Wang

Liang

Cai

et al. 2022

Journal of Cardiac Surgery

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“…[47,48] Treatment using TCM-based interventions emerged in 2017 to 2019 alone or in conjunction with Western medicine, to facilitate “double heart recovery,” relieve anxiety and reduce the occurrence of MACE. [49–52] In addition, TCM exercises such as Tai Chi Chuan and Ba Duan Jin have also been shown to improve PCI prognosis. Further evidence is expected to support the role of TCM in improving the prognosis of PCI.…”

Section: Discussionmentioning

confidence: 99%

Hot spots and trends in PCI prognostic research: A bibliometric analysis with CiteSpace

Guo,

Luo,

Huang

et al. 2023

Medicine

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Background: The number of patients undergoing percutaneous coronary intervention (PCI) procedures is increasing along with the number of studies involving guidelines, prognostic assessments, and cardiac rehabilitation related to PCI strategies. However, fewer studies have reported the mapping of knowledge structure and hotspot analysis in this field. Our goal was to discuss and analyze the current status, hot spots and developmental trends associated with research into the prognosis of patients undergoing PCI, and to provide reference for PCI-related research. Methods: The Web of Science Core Collection and China Knowledge Network were searched for relevant literature from January 2003 to October 2022, and CiteSpace 6.1. R3 software was used to analyze the co-occurrence, clustering, and emerging authors, institutions, and keywords. Results: A total of 2666 English and 2010 Chinese publications were included. The number of publications showed a growing trend. The author with the maximum number of articles was Xu Bo. The institutions with high productivity were Peking Union Medical College and Capital Medical University. Although the number of Chinese articles was high, the cooperation between institutions was low and the impact was small. The results of the analysis suggest a shift in the focus of keywords from coronary artery disease and PCI to studies involving the assessment and intervention of risk factors associated with poor prognosis of PCI. Traditional Chinese Medicine and anxiety represent the emerging direction of PCI prognosis. The assessment of major adverse cardiovascular events and cardiac rehabilitation require careful analysis in post-PCI research. Conclusion: The findings of this bibliometric study present a comprehensive and systematic overview of the PCI prognosis, based on the analysis of the current status and trends in research, which may facilitate the identification of hot topics and new directions for future research.

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“…Based on conventional Western medicine, the combination of TCM adjuvant therapy can coordinate with Western medicine to regulate cardiac function in multiple ways and multiple targets and inhibit the occurrence and development of MACE, thus improving the prognosis of patients and improving the quality of life. [14] Compound Danshen dropping pills are widely used in the treatment of coronary heart disease. The drug can expand the coronary artery, improve coronary flow, increase myocardial blood oxygen supply, improve myocardial ischemic injury, and relieve symptoms of cardiac dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…TCM has received increasing attention for the prevention and treatment of post-PCI complications. Based on conventional Western medicine, the combination of TCM adjuvant therapy can coordinate with Western medicine to regulate cardiac function in multiple ways and multiple targets and inhibit the occurrence and development of MACE, thus improving the prognosis of patients and improving the quality of life [14] . Compound Danshen dropping pills are widely used in the treatment of coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

Effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after percutaneous coronary intervention in patients with coronary heart disease

Yuan

Jiang

2022

Medicine

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Background: Percutaneous coronary intervention (PCI) is an important means for the treatment of coronary atherosclerotic heart disease and has effectively reduced the mortality of coronary heart disease. However, reperfusion can also cause certain damage to the vascular endothelium, leading to the major adverse cardiovascular events. Compound Danshen dropping pill is a Chinese patent medicine preparation. At present, many studies have evaluated the effect of compound Danshen dropping pill in reducing the incidence of adverse cardiovascular events after PCI. This study systematically evaluated the effect of compound Danshen dropping pills on major adverse cardiovascular events and quality of life after PCI and provides a reference for clinical application and research.Methods: All randomized controlled trials on the effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after PCI for coronary heart disease were searched for. The search was conducted from database inception to January 2022. Data extraction and quality assessment were performed by 2 reviewers according to the Protocol Guidelines for Systematic Reviews and Meta-analyses Protocols statement guidelines. Meta-analysis was performed using Review Manager Version 5.4 software and Stata 16 software. Results:The results of this study will allow for systematically evaluation of the effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after PCI for coronary heart disease.Conclusion: This study will provide objective evidence of a basis for compound Danshen dropping pills reducing adverse cardiovascular events and improving quality of life after PCI.

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Chinese Herbal Medicines for Restenosis After Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Controlled Trials

Cited by 12 publications

References 13 publications

The potential function of SP1 and CPPED1 in restenosis after percutaneous coronary intervention

The potential function of SP1 and CPPED1 in restenosis after percutaneous coronary intervention

Hot spots and trends in PCI prognostic research: A bibliometric analysis with CiteSpace

Effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after percutaneous coronary intervention in patients with coronary heart disease

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