Chinese Medicines in the Treatment of Prostate Cancer: From Formulas to Extracts and Compounds

Wang, Xueni; Fang, Gang; Pang, Yuzhou

doi:10.3390/nu10030283

Cited by 45 publications

(22 citation statements)

References 80 publications

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“…Chinese medicines are usually divided into pure compounds, herb extracts, and formulations. Formulations from Chinese medicines are extensively employed in Chinese hospitals for clinical cancer treatment [25]. Numerous Chinese herb extracts have been reported to show inhibitory effects on cancers [26].…”

Section: Chinese Medicines and Cancer Treatmentmentioning

confidence: 99%

Chinese Medicines for Cancer Treatment from the Metabolomics Perspective

Guo¹,

Tan²,

Wang³

et al. 2020

Metabolomics - New Insights Into Biology and Medicine

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Cancer is one of the most prevalent diseases all over the world with poor prognosis and the development of novel therapeutic strategies is still urgently needed. The large amount of successful experiences in fighting against cancer-like diseases with Chinese medicine has suggested it as a great source of alternative treatments to human cancers. Cancer cells have been shown to own a predominantly unique metabolic phenotype to facilitate their rapid proliferation. Metabolic reprogramming is a remarkable hallmark of cancer and therapies targeting cancer metabolism can be highly specific and effective. Based on the sophisticated study of small molecule metabolites, metabolomics can provide us valuable information on dynamically metabolic responses of living systems to certain environmental condition. In this chapter, we systematically reviewed recent studies on metabolism-targeting anticancer therapies based on metabolomics in terms of glucose, lipid, amino acid, and nucleotide metabolisms and other altered metabolisms, with special emphasis on the potential of metabolic treatment with pure compounds, herb extracts, and formulations from Chinese medicines. The trends of future development of metabolism-targeting anticancer therapies were also discussed. Overall, the elucidation of the underlying molecular mechanism of metabolism-targeting pharmacologic therapies will provide us a new insight to develop novel therapeutics for cancer treatment.

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Section: Chinese Medicines and Cancer Treatmentmentioning

confidence: 99%

Chinese Medicines for Cancer Treatment from the Metabolomics Perspective

Guo¹,

Tan²,

Wang³

et al. 2020

Metabolomics - New Insights Into Biology and Medicine

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show abstract

“…Toosendanin (TSN), an active component in TCM, has shown an enhanced attenuation towards the progression of pancreatic cancer [62][63][64]. In a dose-dependent manner TSN suppresses the viability and growth of pancreatic cancer cells in a dosedependent manner.…”

Section: Pancreatic Cancermentioning

confidence: 99%

Insights on Cancer Preventive Approaches Using Plant Based Extracts

Nair¹,

Bisht²,

Tk³

2018

Asian J Biomed Pharmaceut Sci

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Cancer is one of the fatal diseases, and it continues to pose a significant health problem worldwide. Although great efforts are being done to discover a cure, cancer still remains a very prominent cause of mortality in humans, and its effective treatment is a formidable challenge. Although cancer therapies have been performed throughout the history, the efficacy of the treatment still remains a challenge. In recent years, natural product compounds have become the first choice of treatment in many cases. Gene therapy, in addition, is offering selective new methods for treatment. This review emphasizes the advancements cancer treatment using naturally derived products with significantly less toxicity and more efficacies; thereby enhancing the understanding of different cancers and potential of the plant based extract in the anti-cancer field.

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“…Recently, attention has focused on alternative therapies that offer fewer side effects compared to the conventional treatment modalities. Traditionally, prostate cancer treatment includes the use of traditional Chinese medicine [ 10 ], such as Celastrol, which is an active compound extracted from the root bark of Tripterygium wilfordii , commonly known as “Thunder of God Vine” [ 11 , 12 ]; Ginkgo biloba [ 13 ]; Dysosma versipellis [ 14 ]; Saussurea involucrate [ 15 ]; and other traditional plants, including Cannabis sativa [ 6 , 16 , 17 , 18 ]. Cannabis has always been very controversial due to its recreational uses; however, in recent years, an increasing public and scientific interest in its medical applications has emerged [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cannabinoids and Prostate Cancer: A Systematic Review of Animal Studies

Singh

Jamshidi

Zomer³

et al. 2020

IJMS

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Prostate cancer is a major cause of death among men worldwide. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation, as well as potential anti-cancer agents. The aim of this review was to evaluate the effect of cannabinoids on in vivo prostate cancer models. The databases searched included PubMed, Embase, Scopus, and Web of Science from inception to August 2020. Articles reporting on the effect of cannabinoids on prostate cancer were deemed eligible. We identified six studies that were all found to be based on in vivo/xenograft animal models. Results: In PC3 and DU145 xenografts, WIN55,212-2 reduced cell proliferation in a dose-dependent manner. Furthermore, in LNCaP xenografts, WIN55,212-2 reduced cell proliferation by 66–69%. PM49, which is a synthetic cannabinoid quinone, was also found to result in a significant inhibition of tumor growth of up to 90% in xenograft models of LNCaP and 40% in xenograft models of PC3 cells, respectively. All studies have reported that the treatment of prostate cancers in in vivo/xenograft models with various cannabinoids decreased the size of the tumor, the outcomes of which depended on the dose and length of treatment. Within the limitation of these identified studies, cannabinoids were shown to reduce the size of prostate cancer tumors in animal models. However, further well-designed and controlled animal studies are warranted to confirm these findings.

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Chinese Medicines in the Treatment of Prostate Cancer: From Formulas to Extracts and Compounds

Cited by 45 publications

References 80 publications

Chinese Medicines for Cancer Treatment from the Metabolomics Perspective

Chinese Medicines for Cancer Treatment from the Metabolomics Perspective

Insights on Cancer Preventive Approaches Using Plant Based Extracts

Cannabinoids and Prostate Cancer: A Systematic Review of Animal Studies

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