Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency syndrome

Zhao, Qiqi; Gao, Xin; Ge, Yan; Zhang, Aihua; Sun, Hui; Han, Ying; Li, Wenxiu; Liu, Liang; Wang, Xijun

doi:10.1007/s11684-019-0705-9

Cited by 36 publications

(13 citation statements)

References 51 publications

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“…However, TCM is also composed of two sides. The "multicomponent-multi-target" is TCM's advantage, but it created difficulties in quality control and the elucidation of pharmacodynamic substances [5,6]. Therefore, to ensure the safety and effectiveness of TCM, it is essential to establish rapid, sensitive, high-throughput, and highly selective analytical methods, which can characterize and identify the component information encompassed in TCM, investigate the detailed biological mechanism of TCM, and the prominent compounds can be further developed as specific drugs [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Rapid characterization of the constituents in Jigucao capsule using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Zhang

Tan

et al. 2021

J of Separation Science

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Jigucao capsule is a well‐known Chinese patent medicine for the treatment of acute and chronic hepatitis and cholecystitis. The chemical components of Jigucao capsule were not clear resulting from the paucity of relevant studies, which hindered the research of the pharmacological mechanism, the comprehensive development, and utilization of Jigucao capsule in clinical studies. By establishing a high‐throughput ultra‐performance liquid chromatography quadrupole time of flight mass spectrometry in combination with intelligent UNIFI software data processing platform to automatically characterize and identify the chemical profile of Jigucao capsule, 144 compounds were determined rapidly, including 34 terpenoids, 25 flavonoids, 22 steroids, 21 phenylpropanoids, 10 glycosides, six alkaloids, 13 organic acids, and other 13 components. These compounds may be the active components of Jigucao capsule. In this study, a rapid and robust method for comprehensively analyzing the chemical composition of Jigucao capsule was described and established for the first time. The results will provide a reference for the quality control of Jigucao capsule and the establishment of a higher quality standard, as well as for the pharmacodynamic material basis research.

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Section: Introductionmentioning

confidence: 99%

Rapid characterization of the constituents in Jigucao capsule using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Zhang

Tan

et al. 2021

J of Separation Science

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“…DTU, PAC, and DTR are three major bioactive triterpene acids in Poria , and they were usually selected as quality markers in the quality evaluation of Poria ( 10 , 11 ) and formulation containing Poria . 12 Especially, PAC has been reported to induce autophagy concerning the IGF-1 signaling pathway in the aged cells 13 and autophagy is closely related to the pathogenesis of AD. 14 Similarly, the major bioactive compounds in Acori Tatarinowii Rhizoma are volatile oils, among which AAS and BAS are two representative and indispensable compounds in the quality evaluation of Acori Tatarinowii Rhizoma .…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Quality Assessment of Kaixin Powder by HPLC–DAD Quantification and HPLC–QTOF-MS/MS Confirmation

et al. 2021

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Kaixin Powder (KXP) is a classic formula for treating morbid forgetfulness in ancient China. To guarantee the efficacy and safety of KXP, a simple and accurate HPLC–DAD method has been established and validated for the quantitative analysis of seven bioactive compounds in KXP. Dehydrotumulosic acid (DTU) and dehydrotrametenolic acid (DTR) were quantified in KXP for the first time. Good chromatographic separation was conducted on a Kromasil 100-5 C 18 column (250 mm × 4.6 mm, 5 μm) by gradient elution using mobile phases containing acetonitrile and 0.1% formic acid aqueous solution at different detection wavelengths. The calibration curves of each compound showed good linearity ( r ≥ 0.9990), and the LOD and LOQ were in the ranges of 0.01–0.10 and 0.03–0.40 μg/mL, respectively. The relative standard deviations (RSDs) of intra-day and inter-day precisions were in the ranges of 0.45–1.74% and 0.56–2.32%, respectively. All recoveries were in the range of 93.6–105.5% with an RSD no more than 2.77%. These quantification results of seven compounds determined in the samples were further confirmed by HPLC–QTOF-MS/MS. This study provides a useful and simple method for analyzing the major bioactive compounds and improves the quality assessment research of KXP.

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“…The fundamental purpose of quality control is to control the effectiveness of herbal medicines ( Liu et al, 2016 ). Pharmacodynamic material basis-guided quality markers discovery cuts to the heart of quality control and provides the foundation of standardization studies of herbal medicines and establishment of quality standards ( Sun et al, 2019 ; Wang et al, 2019 ; Zhang et al, 2018 ; Zhao et al, 2019 ). Panax quinquefolius (PQ) is a famous herbal medicine with the efficacy of outstanding replenishing qi, nourishing yin, clearing heat and generating fluid ( Yu et al, 2014 ).…”

Section: Chinmedomics Applications In Herbal Medicines Researchmentioning

confidence: 99%

Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines

Han

Sun

Zhang

et al. 2020

Pharmacology & Therapeutics

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104

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Herbal medicines have accumulated valuable clinical experience in thousands of years of applications in traditional Chinese medicine (TCM) or ethnomedicine. The unique multi-target efficacy on complex diseases made herbal medicines gained a global popularity in recent years. However, the characteristic of multi-component acting on multi-target poses a dilemma for the evaluation of therapeutic efficacy of herbal medicines. Advances in metabolomics enable efficient identification of the various changes in biological systems exposed to different treatments or conditions. The use of serum pharmacochemistry of TCM has significant implications for tackling the major issue in herbal medicines development—pharmacodynamic material basis. Chinmedomics integrates metabolomics and serum pharmacochemistry of TCM to investigate the pharmacodynamic material basis and effective mechanisms of herbal medicines on the basis of TCM syndromes and holds the promise of explaining therapeutic efficacy of herbal medicines in scientific language. In this review, the historical development of chinmedomics from concept formation to successful applications was discussed. We also took the systematic research of Yin Chen Hao Tang (YCHT) as an example to show the research strategy of chinmedomics.

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Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency syndrome

Cited by 36 publications

References 51 publications

Rapid characterization of the constituents in Jigucao capsule using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Rapid characterization of the constituents in Jigucao capsule using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Comprehensive Quality Assessment of Kaixin Powder by HPLC–DAD Quantification and HPLC–QTOF-MS/MS Confirmation

Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines

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