Chiral Analyses of Pollutants by Capillary Electrophoresis

Abstract

Abstract:The determination of enantiomeric composition of chiral xenobiotics and pollutants is a very difficult job due to their low amounts and poor detection by commonly used UV detector. But this sort of analysis is an important issue from the health point of view. The chiral analyses of these notorious pollutants by capillary electrophoresis have been discussed in this article. This review discusses the new trends and advancements, which have been achieved in the analyses of chiral pollutants using capillary electrophoresis and the state-of-art of their enaniomeric resolution. This article focuses on sample treatment, applications, optimization, detection, mechanisms of chiral resolution and future perspectives of CE in chiral resolution of xenobiotics. Besides, efforts have also been made to suggest the improvement in CE machine to make it ideal for the analyses of chiral xenobiotics at trace levels.

Advances in chiral separations by nonaqueous capillary electrophoresis in pharmaceutical and biomedical analysis

“…During the course of time some modification have been made and CE got a recognition in 1989 . Currently, CE is a versatile technique of high speed, high sensitivity, low limit of detection, and inexpensive running cost, which is a good breakthrough in analytical science . CE is also suitable for samples that may be difficult to separate by LC, or at least complementary to this technique, since the principles of separations are different.…”

Enantio‐separation of drugs with multiple chiral centers by chromatography and capillary electrophoresis

“…The high efficiency of CE is because of the flat profile and homogeneous partition of the chiral selector in electrolyte, minimizing mass transfer. Literature survey indicates many publications on chiral separation by CE (Aboul‐Enein and Al‐Duraibi, ; Ali et al ., , , ; Ali and Aboul‐Enein, ) but only one paper was found describing enatio‐resolution of a racemate containing more than one chiral center.…”

“…Only a few papers are available on this issue. The most commonly used racemic drugs with two chiral centers are formoterol, labetalol, nadolol, indinolol, nebivolol and diltiazem hydrochloride (Al‐Othman et al ., ; Gupta et al ., ; Ali et al ., , , , , , ; Ali and Aboul‐Enein, ; Aboul‐Enein and Ali, , , , , ; Schmid et al ., ; Aboul‐Enein et al ., , ; Aboul‐Enein and Al‐Duraibi, ; Aboul‐Enein, ).…”

Enantioselectivity of Chiral Pesticides in the Environment

“…Capillary electrophoresis (CE) is restricted to charged compounds analysis, but its micellar electrokinetic chromatography technique (MEKC) is able to also separate the neutral pesticides. Usually CE utilizes the [2,6,12]. Chiral chromatographic separation techniques are based on chiral recognition mechanisms and were developed to also contribute to the studies of enantioselective behavior of the chiral pesticides in environment.…”