Abstract:Circular dichroism (CD) spectra contain information about absolute configurations and conformations of chiral compounds. However, extracting this information from CD spectra in solution is challenging, because the spectra exhibit only the averaged CD values of all different conformers. CD spectroscopy of jet-cooled molecules can provide conformation-specific CD spectra, but its application to biomolecules has been limited due to the difficulty of their production in the gas phase. Here, we obtained the first C… Show more
“…S1 in ESI†). 25–30 Details of the experimental setup were described elsewhere. 31,32 Enantiomerically pure (−)-nicotine (FUJIFILM Wako) and racemic (±)-nornicotine (FUJIFILM Wako) were used because only (−)-nicotine is present in the Nicotiana plant, while both (+)- and (−)-nornicotine exist in nature.…”
The infrared (IR) spectra of gas phase protonated nicotine has been measured in the never-before probed N-H “fingerprint region” (3,200–3,500 cm−1). The protonated molecules generated by an electrospray source are...
“…S1 in ESI†). 25–30 Details of the experimental setup were described elsewhere. 31,32 Enantiomerically pure (−)-nicotine (FUJIFILM Wako) and racemic (±)-nornicotine (FUJIFILM Wako) were used because only (−)-nicotine is present in the Nicotiana plant, while both (+)- and (−)-nornicotine exist in nature.…”
The infrared (IR) spectra of gas phase protonated nicotine has been measured in the never-before probed N-H “fingerprint region” (3,200–3,500 cm−1). The protonated molecules generated by an electrospray source are...
“…S1, ESI ‡). [37][38][39][40][41][42][43] Details of the experimental procedures are described in ESI. ‡ In brief, H + BC ions generated in an electrospray ionization source were introduced into a linear ion trap (LIT) 44,45 kept at 170 K, where they were hydrated by introducing water vapor.…”
The protonation site of molecules can be varied by their surrounding environment. Gas-phase studies, including the popular techniques of infrared spectroscopy and ion mobility spectrometry, are a powerful tool for...
“…In practice the weakness of ECD makes extremely challenging its application to dilute matter in the gas phase, in particular under jet-cooled or cryogenic ion trap conditions. [11][12][13] In contrast, the recently introduced Photoelectron Circular Dichroism (PECD) is ideally suited for studying gas-phase molecules. [14][15][16] PECD is observed as a forward-backward asymmetry in the photoelectron angular distribution with respect to the light axis for randomly oriented chiral molecules photoionized by CPL.…”
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