Chiral discrimination of limonene by use of β-cyclodextrin-coated quartz-crystal-microbalances (QCMs) and data evaluation by artificial neuronal networks

Abstract

The enantiomeric composition of the chiral flavoring agent limonene was analyzed by means of a quartz-crystal microbalance (QCM) sensor. As chiral selectors three different modified beta-cyclodextrins were investigated. The selector molecules were applied as mixtures in different polysiloxane matrices. The chiral separation factors alpha for limonene obtained at 30 degrees C by gas chromatography and by use of the QCM sensor were comparable. Evaluation of sensor data was performed by use of an artificial neuronal network (ANN); this enabled prediction of the enantiomeric composition of the gas mixtures.

A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applications of acoustic physics to the analysis of biomolecular interactions

“…Other examples for small molecule detection, in particular environmental contaminants include petroleum hydrocarbons (Fahnrich et al, 2002;Applebee et al, 2004), Cr 6þ , Cr 3þ , Cd 3þ , Cu 2þ and other ions (Howie and Hoagland, 2002;Mirmohseni and Oladegaragoze, 2002;Tani and Umezawa, 2003;Sung and Shih, 2005), estrogenic compounds (Murata et al, 2003;Luck et al, 2004), aliphatic amines (Mirmohseni and Oladegaragoze, 2003), phenol (Mirmohseni and Oladegaragoze, 2004), sulfur dioxide (Palenzuela et al, 2005), NO x (Seh et al, 2005), enantiomers , pesticides , doxorubicin (Serpe et al, 2005), cholesterol (Ram et al, 2001), limonene (Fietzek et al, 2001), alcohols (Loergen et al, 2005), dioxins Kurosawa et al, 2003) and cisplatinum drugs .…”

A Look into the Future: Chiral Analysis Using Chemical Sensor Technology

“…However, other platforms, such as emissive cadmium selenide [16], TSR [17,18], optical [19][20][21][22][23], field effect [24], immunological [25], and electrochemical [26][27][28][29] sensors, have been investigated. In terms of moving chromatographic chiral analysis to routine chemical sensing, the quartz crystal microbalance platform looks to be the most promising [30][31][32][33][34][35][36][37][38][39][40]. Like earlier attempts at developing chiral sensors, initial applications for the quartz crystal microbalance began with gas-phase detection [30][31][32][33][34][35].…”

“…In terms of moving chromatographic chiral analysis to routine chemical sensing, the quartz crystal microbalance platform looks to be the most promising [30][31][32][33][34][35][36][37][38][39][40]. Like earlier attempts at developing chiral sensors, initial applications for the quartz crystal microbalance began with gas-phase detection [30][31][32][33][34][35]. This work used cyclodextrins [30,31,34,35], and molecularly imprinted polymer (MIP) films [32,33].…”

“…Like earlier attempts at developing chiral sensors, initial applications for the quartz crystal microbalance began with gas-phase detection [30][31][32][33][34][35]. This work used cyclodextrins [30,31,34,35], and molecularly imprinted polymer (MIP) films [32,33]. Chiral selectivity based on sensor technology was compared to traditional gas chromatography [31].…”

Acoustic methods of detection in gas chromatography

“…This is often very beneficial since molecular weight is one of the key factors used in identifying chemical species. Given these advantages, there have been an increasing number of modern applications that use various forms of acoustic sensors to detect species in the gas phase [1][2][3][4][5][6][7][8][9][10][11]. Work in this area has also been examined comprehensively in a more recent overview of the subject [12].…”