Chiral HPLC Separation of Protected Amino Acids

Esquivel, J. B.; Sanchez, Carl; Fazio, M. J.

doi:10.1080/10826079808000508

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High-performance Liquid Chromatography1

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Cited by 13 publications

(2 citation statements)

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“…The unusual amino acids also were resolved in a GC system on a Chirasil-L-Val column (105). Protected amino acids were directly separated without further chemical modification using proteinbased and macrocyclic columns (108). Chiral columns used in this study were Chirobiotic T (teicoplanin), Ultron ovomucoid (OVM), and human serum albumin (HSA).…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Chiral Separations

Ward

2000

Anal. Chem.

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Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Chiral Separations

Ward

2000

Anal. Chem.

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“…4,10,12,15,17,18,20,21,28 -36 More recently, separations have been observed with various teicoplanin-related macrocyclic chiral selectors, specifically A40,926, 37 -39 and a modified aglycone version of teicoplanin. 40 The glycopeptide ristocetin A has demonstrated resolving capacity for amino acids, di-and tripeptides, nonsteroidal antiinflammatories, antineoplastics, and other compounds. 4,9,18,20,36,41 -44 Additional reported macrocyclic antibiotic chiral selectors include rifamycin B and SV, 45,46 actaplanin A, 47 d-(+)-tubocurarine chloride, 48 erythromycin, 49 A35512B, 50 and avoparcin.…”

mentioning

confidence: 99%

Enantiomeric separation of dansyl amino acids using macrocyclic antibiotics as chiral mobile phase additives by narrow‐bore high‐performance liquid chromatography

et al. 2004

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Seven macrocyclic antibiotics were evaluated as chiral selectors for the enantiomeric separation of 11 dansyl amino acids using narrow-bore high-performance liquid chromatography (HPLC). The macrocyclic antibiotics were incorporated as mobile phase additives to determine the enantioselective effects on the chiral analytes. The resolution and capacity factor (k') of each analyte were assessed while varying the structure of macrocyclic antibiotic and the mobile phase buffer pH. The selectivity of the chiral selectors was measured as a function of changes in these parameters. All 11 dansyl amino acids were separated by at least one of the chiral selectors. Three-dimensional computer modeling of the more effective chiral selectors illustrated the importance of macrocyclic antibiotic structure concerning stereospecific analyte interaction.

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Application of synchronous cyclic capillary electrophoresis: Isotopic and chiral separations

Zhao

Jorgenson

1999

J. Micro. Sep.

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Chiral HPLC Separation of Protected Amino Acids

Cited by 13 publications

References 13 publications

Chiral Separations

Chiral Separations

Enantiomeric separation of dansyl amino acids using macrocyclic antibiotics as chiral mobile phase additives by narrow‐bore high‐performance liquid chromatography

Application of synchronous cyclic capillary electrophoresis: Isotopic and chiral separations

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