Chiral metal-organic frameworks and their composites as stationary phases for liquid chromatography chiral separation: A minireview

Dual-mode detection of 2,6-pyridinedicarboxylic acid based on the enhanced peroxidase-like activity and fluorescence property of novel Eu-MOFs

“…The metal–organic frameworks (MOFs) are composed of metal ions and organic ligands, which have excellent characteristics such as adjustable structure, high surface area, abundant active sites and controllable surface functionalities. 16 The MOFs are extensively used in gas storage, 17 selective catalysis 18 and drug delivery. 19,20 Nanozymes are nanomaterials that have enzyme-like properties, contrasting to native enzymes, which have the advantages of high selectivity, low cost, stable nature and superior catalytic activity.…”

Chiral voltammetric sensor on the basis of nanosized MFI zeolite for recognition and determination of tryptophan enantiomers

“…The classical methods for determining and recognizing the enantiomers of biologically active substances include circular dichroism [1], capillary electrophoresis [2,3], chromatography [4][5][6][7], etc. However, researchers who determinethe enantiomers by these methods face problems, the most significant of which are the small sensitivity of the methods, the use of expensive equipment, and low productivity for routine analysis.…”

Preparation of chiral metal–organic framework l-his-MIL-53-NH2@SiO2 composite by in situ growth and chiral post-modification strategies for HPLC enantiomeric separation

“…22 Therefore, not only the skeleton structure of chiral MOFs can be optimized for enantioseparation, but also the enantiomeric separation performance can be improved by optimizing the morphology and particle size of CMOF based stationary phases. 23 In HPLC, there is a close relationship between eddy diffusion and the column efficiency of packed columns. In order to improve the separation efficiency of the columns, it is necessary to select chromatographic packing particles with high uniformity, which is beneficial for significantly reducing eddy current diffusion and analysis time.…”

“…Another effective strategy is to immobilize a uniform achiral MOF shell layer on the surface of SiO 2 microspheres and introduce chiral functional groups through chiral post-modification method to prepare chiral core-shell composite materials. 23 However, there are few research reports on the preparation of chiral core-shell composite materials for HPLC separation based on this strategy, which is still in its early stages. Therefore, it is necessary to continuously explore and prepare novel chiral MOFs@SiO 2 core-shell microspheres composite for chiral separations using different strategies.…”

“…22 Therefore, not only the skeleton structure of chiral MOFs can be optimized for enantioseparation, but also the enantiomeric separation performance can be improved by optimizing the morphology and particle size of CMOF based stationary phases. 23…”