Chiral microenvironment-responsive mesoporous silica nanoparticles for delivering indometacin with chiral recognition function

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

“…Well-defined surface of mesoporous matrices allows conjunction with pore-blocking materials to prevent premature cargo release, with stimuli-responsive ligands (nanovalves or gate keepers [ 145 ]) for controlled release or with specific ligands for targeting [ 151 ]. Stimuli-responsive drug release refers to the release of the drug trigged by a variety of external factors including temperature, light, pH, heat, tumors, enzyme presence, chiral environment or redox potential [ 115 , 161 , 162 ]. These approaches were shown to improve the therapeutic efficacy and reduce side effects of the drugs which is of great importance in pharmaceutical practice and can lift DDSs research to a new level.…”