Chiral nano heterobimetallic DNA receptors: In vitro binding studies, cleavage activity and DNA condensation studies (TEM and AFM imaging)

Synthesis, characterization, crystal structure, DNA- and HSA-binding studies of a dinuclear Schiff base Zn(II) complex derived from 2-hydroxynaphtaldehyde and 2-picolylamine

“…This spectral characteristic suggests that this complex interacts with FS-DNA through the partial insertion of the ligand aromatic rings to the FS-DNA groove. Moreover, the small redshift may be attributed to the groove binding affinity of the complex which is due to the presence of a phenyl ring in the coordinated ligand [57].…”

Chiral halogenated Schiff base compounds: green synthesis, anticancer activity and DNA-binding study

“…The structures of the title ligands (Scheme 1) show that they are not planner and therefore, probability of their intercalation is very low. This spectral characteristic suggests that the ligands interact with FS-DNA through the partial insertion of the aromatic rings to the FS-DNA groove [ [36], [37], [38]]. To quantitatively evaluate the affinity of the ligands with FS-DNA, the intrinsic binding constant Kb was determined by monitoring the changes in absorbance using the following equation [39]:…”

Synthesis and characterization of steroidal heterocyclic compounds, DNA condensation and molecular docking studies and their in vitro anticancer and acetylcholinesterase inhibition activities

“…Several numbers of drugs are unable to be effective due to the lack of information of their structural and morphological details. 32 To obtain the morphological and structural information of the compound and the condensates, tapping mode AFM experiments were performed using commercially etched silicon tips as AFM probes. Two and three dimensional AFM images of the compound and the condensate materials are shown in Fig.…”