Synthesis and characterization of steroidal heterocyclic compounds, DNA condensation and molecular docking studies and their in vitro anticancer and acetylcholinesterase inhibition activities

Abstract

A facile and efficient approach for the synthesis of steroidal heterocyclic compounds (4–12) has been performed. Furthermore, these newly synthesized compounds were evaluated for their various biological activities.

Graphene‐mesoporous anatase TiO2 nanocomposite: A highly efficient and recyclable heterogeneous catalyst for one‐pot multicomponent synthesis of benzodiazepine derivatives

“…In continuation of our previous work , herein we report, the comparative study of mesoporous TiO 2 NPs and graphene‐mesoporous TiO 2 nanocomposites (Gr@TiO 2 NCs) as a catalyst. Both the catalyst were synthesized through wet chemical route.…”

Recent syntheses of steroidal derivatives containing heterocycles

“…Compounds 69-73 were prepared similarly as the procedures for the synthesis of compounds 58-66. In 2015, a series of new steroidal heterocyclic compounds with significant anti-tumor and antioxidant activities was successfully synthesized by Abad et al 42 All the compounds (Scheme 18) were prepared by refluxing compounds 74e-76e with o-aminothiophenol/ o-aminophenol/ o-phenylenediamine in DMSO. Their anti-tumor activity in vitro was evaluated against Hep3B (human hepatocellular carcinoma), MCF7 (human breast adenocarcinoma), HeLa (human cervical carcinoma) cancer cell lines and on normal PBMCs (peripheral blood mononuclear cells).…”

Discovery of a novel oxadiazine derivative of glucocorticoids endowed with DNA binding activities and molecular docking studies

“…For biological activity the Lipinski's rule was used as a filter to choose the reasonable scaffolds [2,[23][24][25][26].…”

“…Steroidal compounds have shown tremendous potential as putative curative agents for cancers and other diseases. It has been shown in recent studies that incorporation of heteroatoms (N/O/S) enhances the biological activities of steroid molecules [1][2][3][4][5]. It was proved by various in vivo and in vitro assays which show significant antimicrobial, anti-inflammatory, hypotensive, hypocholesterolemic and diuretic activities [6][7][8][9][10][11][12][13][14][15].…”