Chiral resolution of racemic phenylpropanoids with tyrosinase inhibitory activities from the fruits of
            <i>Crataegus pinnatifida</i>
            Bge

Li, Zhiyuan; Zhao, Peng; Song, Shao‐Jiang; Huang, Xiao‐Xiao

doi:10.1111/jfbc.14304

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…The results showed that isomer (7′ R* , 8′ R* , and 8 R* )- 1h exhibited a high DP4+ probability of approximately 99.84% (Table ). The erythro-configuration of C-7′/C-8′ was determined through the result, and the coupling constant ( J 7′,8′ = 5.9 Hz, <6.5 Hz) also confirmed the erythro-configuration of C-7′/C-8′. – …”

Section: Resultsmentioning

confidence: 71%

Antichilblain Components in Eggplant Based on Network Pharmacology and Biological Evaluation

Shi

Chen

et al. 2023

J. Agric. Food Chem.

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Eggplant, the fruit of Solanum melongena L. (Solanaceae), is applied externally to relieve the symptoms of chilblains in the folk in East Asia. However, the mechanisms and biological ingredients are not clear. A network pharmacology approach was used to shed light on the mechanisms of eggplant against chilblains, which illustrated that anti-inflammation and antioxidation are mainly involved in the curative effects. Bioassay-guided assays led to the isolation of 44 ingredients (1–44), including two new natural compounds (1–2) and 42 known compounds. Thirteen compounds (3–15) were first reported from the Solanum genus. The anti-inflammatory and antioxidative effects of all isolates were evaluated, and the results showed that 11 compounds have anti-inflammatory activity and 27 have antioxidant activity. Fatty acids, flavonoids, alkaloids, phenolic acids, saponins, and lignans from eggplant have certain anti-inflammatory and antioxidant effects. These results provide a scientific basis for eggplant to treat chilblains.

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Section: Resultsmentioning

confidence: 71%

Antichilblain Components in Eggplant Based on Network Pharmacology and Biological Evaluation

Shi

Chen

et al. 2023

J. Agric. Food Chem.

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“…The tyrosinase inhibitory activities of all compounds were evaluated using the method previously described in our publication (see the Supporting Information). 19,20 Arbutin and kojic acid were used as positive controls. The inhibitory percentage of tyrosinase was calculated by the following equation:…”

Section: ■ Introductionmentioning

confidence: 99%

“…The crystal structure of the protein (PDB code 2Y9X) was retrieved from the RCSB Protein Data Bank. 19 Detailed steps for molecular docking can be found in the Supporting Information. 11,21 The molecular dynamics (MD) simulation was performed using Gromacs 2022.3 software.…”

Section: ■ Introductionmentioning

confidence: 99%

Hydroxyl-Amide Alkaloids from Pepper Roots: Potential Sources of Natural Antioxidants and Tyrosinase Inhibitors

Xu,

Hu,

et al. 2024

J. Agric. Food Chem.

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Pepper (Piper nigrum L.) is a widely used spice plant known for its fruits and roots, which serve as flavor enhancers in culinary applications and hold significant economic value. Despite the popularity of pepper fruits, their roots remain relatively understudied, with limited research conducted on their bioactive components. This study focused on discovering and separating the primary bioactive amide alkaloids found in pepper roots. The process involved using the antioxidant activity of crude fractions and the Global Natural Products Social Molecular Networking analysis platform. The process led to the discovery of 23 previously unknown hydroxyl-amide alkaloids. Notably, compounds 11, 12, and 14 showed excellent antioxidant activity, while compound 11 exhibited significant inhibitory effects on mushroom tyrosinase. Theoretical exploration of enzyme−ligand interactions was conducted through molecular docking and molecular dynamics simulation. The findings of this study highlight the potential of hydroxyl-amide alkaloids as antioxidant products and natural food preservatives in the pharmaceutical and food cosmetic industries.

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Four pairs of neolignan enantiomers with distinctive isochroman moiety from the fruits of Crataegus pinnatifida and their protective activities against H2O2-induced SH-SY5Y cells

Zhao,

Li,

Hou

et al. 2024

Phytochemistry

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Chiral resolution of racemic phenylpropanoids with tyrosinase inhibitory activities from the fruits of Crataegus pinnatifida Bge

Cited by 3 publications

References 49 publications

Antichilblain Components in Eggplant Based on Network Pharmacology and Biological Evaluation

Antichilblain Components in Eggplant Based on Network Pharmacology and Biological Evaluation

Hydroxyl-Amide Alkaloids from Pepper Roots: Potential Sources of Natural Antioxidants and Tyrosinase Inhibitors

Four pairs of neolignan enantiomers with distinctive isochroman moiety from the fruits of Crataegus pinnatifida and their protective activities against H2O2-induced SH-SY5Y cells

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