Chiral rotational spectroscopy

Cameron, Robert P.; Götte, Jörg B.; Barnett, Stephen M.

doi:10.1103/physreva.94.032505

Cited by 16 publications

(16 citation statements)

References 112 publications

(284 reference statements)

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“…The macro-size of VCD beams are also challenging for such long-pathlength samples, but that has been solved in other IR experiments. Polavarapu has addressed rotation-vibration effects, and has also predicted a rotational analog to VCD, which has become a topic of current theoretical interest [ 86 , 87 , 88 ]. With magnetic VCD (see below), such rotationally resolved spectra are commonly measured.…”

Section: Comparison Of Methodsmentioning

confidence: 99%

Instrumentation for Vibrational Circular Dichroism Spectroscopy: Method Comparison and Newer Developments

Keiderling

2018

Molecules

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Vibrational circular dichroism (VCD) is a widely used standard method for determination of absolute stereochemistry, and somewhat less so for biomolecule characterization and following dynamic processes. Over the last few decades, different VCD instrument designs have developed for various purposes, and reliable commercial instrumentation is now available. This review will briefly survey historical and currently used instrument designs and describe some aspects of more recently reported developments. An important factor in applying VCD to conformational studies is theoretical modeling of spectra for various structures, techniques for which are briefly surveyed.

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Section: Comparison Of Methodsmentioning

confidence: 99%

Instrumentation for Vibrational Circular Dichroism Spectroscopy: Method Comparison and Newer Developments

Keiderling

2018

Molecules

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“…The detailed theory of chiral rotational spectroscopy is presented in our recent article in Physical Review A. 8 Here we summarise the key elements needed to appreciate the example in the next section. We work in the International System of Units, with 0 the vacuum permittivity, c the vacuum speed of light and = h/2π the reduced Planck constant.…”

Section: Theorymentioning

confidence: 99%

“…Recently we have introduced a new technique termed chiral rotational spectroscopy, 8 which promises to enlarge our capabilities to probe molecular chirality and to analyse molecular mixtures and subtle forms of chirality, by accessing orientated information. Chiral rotational spectroscopy builds on standard rotational spectroscopy which probes the discrete rotational energy levels of a molecule typically in the microwave domain.…”

Section: Introductionmentioning

confidence: 99%

Orientated molecular information from chiral rotational spectroscopy

2017

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We present details on how the newly introduced technique of chiral rotational spectroscopy can be used to extract orientated information from otherwise freely rotating molecules in the gas phase. In this technique circularly polarized light is used to illuminate chiral molecules and shift their rotational levels to yield orientated chiroptical information via their rotational spectrum. This enables in particular the determination of the individual, physically relevant components of the orientated optical activity pseudotensor. Using the explicit example of (S)-propylene glycol we show how measuring the rotational spectrum of molecules in the microwave domain allows for the recording of a small set of rotational transitions from which the individual polarizability components can be determined.

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“…So the property of chirality is one of the most profound aspects of the world, and the enantiomerselective tasks of chiral molecules, e.g., enantiomer separation, enantiomer purification, absolute configuration determination, and enantiomeric excess determination, are of great significance. Except the widely used pure chemical means [11][12][13][14][15][16], optical methods are potential candidates for performing the enantiomer-selective tasks of chiral molecules [17][18][19][20][21][22]. Some spectroscopic techniques have been established for the determination of the absolute configuration and enantiomeric excess of a chiral sample, such as circular dichroism [23], vibrational circular dichroism [24], and Raman optical activity [25].…”

Section: Introductionmentioning

confidence: 99%

Two-Path Interference for Enantiomer-Selective State Transfer of Chiral Molecules

Wang

Han

et al. 2020

Phys. Rev. Applied

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With a microwave-regime cyclic three-state configuration, an enantiomer-selective state transfer (ESST) is carried out through the two-path interference between a direct one-photon coupling and an effective two-photon coupling. The π-phase difference in the one-photon process between two enantiomers makes the interference constructive for one enantiomer but destructive for the other. Therefore only one enantiomer is excited into a higher rotational state while the other remains in the ground state. The scheme is of flexibility in the pulse waveforms and the time order of two paths. We simulate the scheme in a sample of cyclohexylmethanol (C7H14O) molecules. Simulative results show the robust and high-fidelity ESST can be obtained when experimental concerns are considered. Finally, we propose to employ the finished ESST in implementing enantio-separation and determining enantiomeric excess.

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Chiral rotational spectroscopy

Cited by 16 publications

References 112 publications

Instrumentation for Vibrational Circular Dichroism Spectroscopy: Method Comparison and Newer Developments

Instrumentation for Vibrational Circular Dichroism Spectroscopy: Method Comparison and Newer Developments

Orientated molecular information from chiral rotational spectroscopy

Two-Path Interference for Enantiomer-Selective State Transfer of Chiral Molecules

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