Chiral Separation in Microflows

Kostur, Marcin; Schindler, Michael; Talkner, Peter; Hänggi, Peter

doi:10.1103/physrevlett.96.014502

Cited by 69 publications

(94 citation statements)

References 16 publications

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“…Consequently, in order to guarantee a higher cost-effectiveness as well as a significant speed-up and to allow for an in-situ investigation of the enantiomer separation at a high time-resolution, there is the need for alternative techniques. Such techniques have been provided by chiral separation in microfluidic devices taking advantage of the fact that enantiomers drift in microflows with a direction depending on their chirality (cf., e.g., [7,21,22,25,26,35]). In this paper, we are concerned with the separation of deformable vesicle-like enantiomers by a specific flow pattern generated by surface acoustic waves (SAWs).…”

Section: Left-and Right-handed Enantiomermentioning

confidence: 99%

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

et al. 2015

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Abstract. Enantiomers are chiral objects such as chemical molecules that can be distinguished by their handedness. They typically occur as racemic compounds of left-and right-handed species which may have completely different properties. Therefore, in applications such as drug design in pharmacology, enantiomer separation is an important issue. Here, we present a new technology for enantiomer separation by surface acoustic wave generated vorticity patterns consisting of pairwise counter-rotating vortices in a carrier fluid. The enantiomers are injected onto the surface of the fluid between two counter-rotating vortices such that right-handed (left-handed) enantiomers get attracted by left-rotating (right-rotating) vortices. In particular, we are concerned with the numerical simulation of this separation process by an application of the finite element immersed boundary method which relies on the solution of a coupled system consisting of the incompressible NavierStokes equations and the equations of motion of the immersed enantiomers described with respect to an Eulerian and a Lagrangian coordinate system. For a model system of deformable, initially L-shaped enantiomers the results of the numerical simulations reveal a perfect separation.

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Section: Left-and Right-handed Enantiomermentioning

confidence: 99%

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

et al. 2015

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“…There is also a recent study of elliptical active particles where particles can rotate in a circular confinement [4]. For structurally chiral objects, dynamical chirality will arise when they are driven by external fields through potential landscapes, and CDC can provide an efficient method for chirality sorting [33][34][35][36]. Very recently, a metastable CDC is reported in a system with achiral interaction [37].…”

Section: Introductionmentioning

confidence: 99%

Emergence of collective dynamical chirality for achiral active particles

Jiang

Ding

et al. 2017

Soft Matter

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Emergence of collective dynamical chirality (CDC) at mesoscopic scales plays a key role in many formation processes of chiral structures in nature, which may also provide possible routines for people to fabricate complex chiral architectures. So far, most of reported CDCs are found in systems of active objects with individual structure chirality or/and dynamical chirality, and whether CDC can arise from simple and achiral units is still an attractive mystery. Here, we report a spontaneous formation of CDC in a system of both dynamically and structurally achiral particles motivated by active motion of cells adhered on a substrate. Active moving, confinement and hydrodynamic interaction are found to be the three key factors. Detailed analysis shows that the system can support abundant collective dynamical behaviors, including rotating droplet, rotating bubble, CDC oscillation, array of collective rotation, as well as interesting transitions such as chirality transition, structure transition and state reentrance.

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“…Instead, passive approaches free from such chiral recognition may also be considered, for instance by relying on transport phenomena, as discussed in the early 70s 3 . More recently, several options based on the coupling between translational and rotational mechanical degrees of freedom in fluid flows have been proposed [4][5][6][7][8][9][10] and realized down to the micron scale by using various kinds of chiral-shaped microparticles made of non-chiral media [11][12][13] . In addition, hydrodynamic propeller effects driven by rotating electric fields have also been considered theoretically 14,15 .…”

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confidence: 99%

Optofluidic sorting of material chirality by chiral light

2014

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International audienceThe lack of mirror symmetry, chirality, plays a fundamental role in physics, chemistry and life sciences. The passive separation of entities that only differ by their handedness without need of a chiral material environment remains a challenging task with attractive scientific and industrial benefits. To date, only a few experimental attempts have been reported and remained limited down to the micron scale, most of them relying on hydrodynamical forces associated with the chiral shape of the micro-objects to be sorted. Here we experimentally demonstrate that material chirality can be passively sorted in a fluidic environment by chiral light owing to spin-dependent optical forces without chiral morphology prerequisite. This brings a new twist to the state-of-the-art optofluidic toolbox and the development of a novel kind of passive integrated optofluidic sorters able to deal with molecular scale entities is envisioned

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Chiral Separation in Microflows

Cited by 69 publications

References 16 publications

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

Emergence of collective dynamical chirality for achiral active particles

Optofluidic sorting of material chirality by chiral light

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