Chiral separation of labetalol stereoisomers in human plasma by capillary electrophoresis

Chiral separations by capillary electrophoresis: Recent developments and applications

“…Goel et al [171] compared the use of HDAS-b-CD and octakis(2,3-di-O-acetyl-6-O-sulfo)-g-CD (ODAS-g-CD) for the separation of all four stereoisomers of labetolol.…”

The role of cyclodextrins in chiral capillary electrophoresis

“…25 Pharmaceuticals [14], tolerodine and analogs [128], omeprazole [130], azabicyclo drug Weak basic model compounds [13], deprenyl [62], alkaloids [124], talinolol [137], labetalol [138] The multicharged basic CDs generate anodic migration, because the wall-adsorbed selectors change the direction of the EOF [53].…”

Stereoselective determination of drugs and metabolites in body fluids, tissues and microsomal preparations by capillary electrophoresis (2000–2010)

“…These and other selectors, such as phosphated-␥-CD (PH-␥-CD) [94,106,126], carboxymethyl-␤-CD (CM-␤-CD) or carboxymethyl-␥-CD (CM-␥-CD) [75,76,86,87,90,100,102,104,105,117,149], carboxyethyl-␤-CD (CE-␤-CD) [120,121] and sulfobutylether-␤-CD (SBE-␤-CD) [88,[91][92][93]125,128,136,138], are products comprising multiple isomers. Finally, single isomer anionic selectors, such as heptakis (2,3-di-O-acetyl-6-O-sulfo)-␤-cyclodextrin (HDAS-␤-CD) [68,107,119,130,146,148,152], octakis-(2,3-di-Oacetyl-6-O-sulfo)-␥-cyclodextrin (ODAS-␥-CD) [64], and heptakis (2,3-di-O-methyl-6-O-sulfo)-␤-cyclodextrin (HDMS-␤-CD) [130], and the single isomer cationic CD derivative 6-monodeoxy-6-mono(3-hydroxy)propylamino-␤-cyclodextrin (PA-␤-CD) [151], were employed. It is important to realize that in chiral bioanalytical drug monitoring selection of a suitable chiral buffer additive is not only dependent on the drug administrated.…”