The role of cyclodextrins in chiral capillary electrophoresis

Juvancz, Zoltán; Kendrovics, Rita Bodáné; Iványi, Róbert; Szente, Lajos

doi:10.1002/elps.200700657

Cited by 119 publications

(98 citation statements)

References 160 publications

(205 reference statements)

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“…Among other possible applications are those in the cosmetic, chemical, and biotechnological industries. Different aspects of cyclodextrin chemistry are addressed in recent reviews [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

DFT studies of cation binding by β-cyclodextrin

et al. 2011

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Interactions of the b-cyclodextrin (b-CD) ligand with Na ? , Cu ? , Mg 2? , Zn 2? , and Al 3? cations were investigated using density functional theory modeling. The objective of this study was to give insight into the mechanism of cation complexation. Two groups of conformers were found. The first group preserved the initial orientation of glucopyranose residues inside the b-CD ligand. The mutual orientation of glucopyranose residues was strongly affected by the cation in the second group of conformers. The system interaction energy was decomposed into electrostatic (ES), Pauli and orbital contributions using the Ziegler-Rauk energy partitioning scheme. The total electrostatic energy, i.e., the sum of ES energy and polarization energy, is the dominating term in the interaction energy. In vacuum, the complexes formed with Al 3? were found to be more stable than with di-and monocations. The vacuum stability sequence was changed in aqueous solution.

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Section: Introductionmentioning

confidence: 99%

DFT studies of cation binding by β-cyclodextrin

et al. 2011

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“…A great variety of chiral selectors can be added to the BGE, which provides a unique flexibility during method development [6]. Analysis times are usually short, very high efficiencies are obtained and the electrolyte composition can be easily varied for optimization.…”

Section: Introductionmentioning

confidence: 99%

Use of coated capillaries for the electrophoretic separation of stereoisomers of a growth hormone secretagogue

et al. 2009

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The diastereoisomeric separation of peptidomimetics of hexarelin, a strong growth hormone secretagogue, in CE has been studied. Highly sulfated-gamma-CD was found to be an appropriate selector for the separation of the stereoisomers. However, non-repeatable analyses were obtained on bare fused silica capillary due to the progressive adsorption of the analytes on the capillary wall. Two types of polyelectrolyte coating agents were tested to prevent this phenomenon. Coating with neutral polyethylene oxide was found to be efficient but resulted in a very long analysis time (about 40 min). Coating with cationic poly(diallyldimethylammonium) chloride was found both to prevent analyte adsorption, reduce analysis time and alter separation selectivity. EOF measurement revealed that the highly sulfated-gamma-CDs were strongly adsorbed on the poly(diallyldimethylammonium) chloride coating surface yielding a stable strong cathodic EOF, which considerably reduced analysis time (about 12 min). Very good repeatability of analysis was obtained (RSD(migration time)<1%).

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“…In this study, CD-modified MEKC (CD-MEKC) is used. CDs are currently by far the most common chiral additives [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers by CD‐modified MEKC

et al. 2009

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An efficient method for the simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers was developed by CD-modified MEKC using a dual mixture of neutral CDs as chiral selector. Three neutral CDs namely hydroxypropyl-beta-CD, hydroxypropyl-gamma-CD, and gamma-CD were tested as chiral selectors at different concentrations ranging from 10, 20, 30 and 40 mM, but enantiomers of the studied fungicides were not completely separated. The best dual chiral recognition mode for the simultaneous separation of cyproconazole, bromuconazole, and diniconazole enantiomers was achieved with a mixture of 27 mM hydroxypropyl-beta-CD and 3 mM hydroxypropyl-gamma-CD in 25 mM phosphate buffer (pH 3.0) containing 40 mM SDS to which methanol-acetonitrile (10%:5% v/v) was added as organic modifiers. The best separation was based on the appearance of 10 peaks simultaneously, with good resolution (R(s) 1.1-15.9), and peak efficiency (N>200,000). Good repeatabilities in the migration time, peak area, and peak height were obtained in terms of RSD ranging from (0.72 to 1.06)%, (0.39 to 3.49)%, and (1.90 to 4.84)%, respectively.

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The role of cyclodextrins in chiral capillary electrophoresis

Cited by 119 publications

References 160 publications

DFT studies of cation binding by β-cyclodextrin

DFT studies of cation binding by β-cyclodextrin

Use of coated capillaries for the electrophoretic separation of stereoisomers of a growth hormone secretagogue

Simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers by CD‐modified MEKC

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