Chiral Synthesis of Functionalized Tetrahydropyridines: γ‐Aminobutyric Acid Uptake Inhibitor Analogues.

Abstract

Pyridine derivatives R 0380 Chiral Synthesis of Functionalized Tetrahydropyridines: γ-Aminobutyric Acid Uptake Inhibitor Analogues. -A new method to prepare chiral tetrahydropyridines such as (VI), (VII), and (XII) is developed. -(RAMACHANDRAN*, P. V.; BURGHARDT, T. E.; BLAND-BERRY, L.; J. Org. Chem. 70 (2005) 20, 7911-7918; Dep. Chem., Purdue Univ., West Lafayette, IN 47907, USA; Eng.) -Jannicke 05-135

Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms

“…In particular Kauffmann and co-workers have prepared homoallylic amines by allylation of 2-azaallyl anions using allyl bromide as an electrophile 34 . Homoallylic amines are incredibly useful precursors for the synthesis of a vast number of biologically active molecules 11,[35][36][37][38][39][40][41][42][43][44][45][46][47][48] . Economical methods to prepare homoallylic amines remain in demand.…”